Protein Alignment POLH and PolH

DIOPT Version :10

• Sequence 1: NP_006493.1
• Gene: POLH / 5429
• HGNCID: 9181
• Length: 713
• Species: Homo sapiens
• Sequence 2: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Alignment Length: 905
• Identity: 263/905 - (29%)
• Similarity: 401/905 - (44%)
• Gaps: 230/905 - (25%)

Human     1 MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWA 65
            |....||||.||||||||.|||::|:|..||:|.|||||..|:|||||||:|.|||.||||.|..
  Fly    10 MQNKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRG 74

Human    66 DDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFA-VIERASIDEAYVDLTSAVQERL 129
            |:||.|||:::|.||...|.||:.:|||:|..||..::.||. ::||||:||||:|:|..|..|:
  Fly    75 DEAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRM 139

Human   130 QKLQG-----QPISADLLPSTYIEGLPQ-------------GPTTAEETVQKEGMRKQGLFQWLD 176
            |::|.     ||   ..|.:|:..|.|.             .|...:|..|..          .|
  Fly   140 QQMQSGAFALQP---QELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMS----------YD 191

Human   177 SLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHG 241
            ...:..:...|::|.:||.:..|:|||:::|||::|||||:|||:|||||.|:||||:||::...
  Fly   192 QNDLPAVRQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLT 256

Human   242 SVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE 306
            ....||..:|:.||:.||||.|..|.|.|||::||::.:|:|..||..|.||||:||:.:.|||:
  Fly   257 ETASLFDSLPVGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGID 321

Human   307 HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSI- 370
            .:.|.||...|:|||.|.|||:..:...:.:|.||.:|:.|:.:||.||..:|:|.|..:||..
  Fly   322 LEAVTPRFYSKSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYV 386

Human   371 -RVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTS-----GIQTEWSPPLTMLFLCATKF 429
             .:.|::..||  |..||..||...:...:..:|| .||.     |.::..:..:..|.:...||
  Fly   387 QDIDGEEVASS--RSTALRDYDQESIVRLSLDLIK-ANTKTFLRPGSESALNNAIKFLGISVGKF 448

Human   430 SASAPSSSTDITSFLSS-----------DPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSLESF 483
            . :..|....:....::           :|..||||.:...:.:|.            ...::||
  Fly   449 E-TVSSGQNKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTD------------EFKMKSF 500

Human   484 FQKAAERQKVKEASLSSLTAPTQAPMSNSPSK-----------PSLPFQTSQSTGTEPFFKQK-- 535
            |....:..|.::|....::|...|..:.:|:|           .::..:.:..|.|...||:.
  Fly   501 FANYLQGAKKEDAKADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFF 565

Human   536 SLLLKQ------------------------------------------------------KQLNN 546
            |..|||                                                      |....
  Fly   566 SQYLKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQ 630

Human   547 SSVSSPQQNPWSNCKALPNSLPTEYPGCVP-------------------VCEGVS---------- 582
            ||.:..:|:|.:...:..|.|..| .|.||                   :...||
  Fly   631 SSDAGQEQDPNTLNDSTGNDLYVE-TGIVPPTLTEDELKPSTSKRKFDEIESSVSNYKECYVEFA 694

Human   583 ------------KLEESSKATPAEM-------------DLAHNSQSMHASSASKSVLEVTQKATP 622
                        |.::.....|.|:             :|:...:|......::|..:::.|.||
  Fly   695 VPNLRTDILPTIKCDQCGANIPDEVKSLQTHRDHHFAQELSRTLRSTEREERTQSRQKISLKPTP 759

Human   623 ------------------NPS--------LLAAEDQVP-------CEKCGSLVPVWDMPEHMDYH 654
                              .||        ....::|.|       |.:|.:.:...|||||:|||
  Fly   760 PKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQEQAPSDPQMNQCPECKAFIKCVDMPEHLDYH 824

Human   655 FALELQKSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKR------PRPEGMQTLESFF 708
            .|..||:...|   .:.:..:|..::.|.:|..|...:.|:      ....|.:|:..||
  Fly   825 VARNLQRELNQ---QDLRTRTAALNKEKISPVQPKKQSQKKLNSTISASSSGTKTIAQFF 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLH	NP_006493.1	PolY_Pol_eta	10..428	CDD:176456	183/443 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..472		6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..527		5/42 (12%)
		zf_UBZ	631..661	CDD:465769	14/36 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..705		6/33 (18%)
		PIP-box. /evidence=ECO:0000269|PubMed:15149598, ECO:0000269|PubMed:16357261	701..708		1/6 (17%)
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	183/442 (41%)
		zf_UBZ	705..736	CDD:465769	4/30 (13%)
		zf_UBZ	805..832	CDD:465769	13/26 (50%)