Protein Alignment POLH and Polh

DIOPT Version :10

• Sequence 1: NP_006493.1
• Gene: POLH / 5429
• HGNCID: 9181
• Length: 713
• Species: Homo sapiens
• Sequence 2: NP_001101674.1
• Gene: Polh / 316235
• RGDID: 1309893
• Length: 689
• Species: Rattus norvegicus
• Alignment Length: 713
• Identity: 551/713 - (77%)
• Similarity: 602/713 - (84%)
• Gaps: 24/713 - (3%)

Human     1 MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWA 65
            ||.|||.||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat     1 MAPGQDLVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWA 65

Human    66 DDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQ 130
            |||||||||||||||||||||||||||||||||||||||.|||||||||||||:|||:||||||:
  Rat    66 DDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSHFAVIERASIDEAYIDLTNAVQERLE 130

Human   131 KLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAV 195
            ||||||:||||||||||||||:|| ..|:||:||.:|||||.|||.||:.|:.|||||:||||||
  Rat   131 KLQGQPVSADLLPSTYIEGLPRGP-AVEDTVEKEDIRKQGLLQWLGSLEKDDPTSPDLRLTVGAV 194

Human   196 IVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGG 260
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   195 IVEEMRAAIERKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGG 259

Human   261 KLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNF 325
            |||||||::||:||||:||||||:|||||||||||||||||||||||:|||||||||||||||||
  Rat   260 KLGASVIDVLGVEYMGDLTQFTEAQLQSHFGEKNGSWLYAMCRGIEHEPVKPRQLPKTIGCSKNF 324

Human   326 PGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRY 390
            ||||||||||||||||||||.||||||||||.||.||||||||||||:|||||||||||||||||
  Rat   325 PGKTALATREQVQWWLLQLALELEERLTKDRTDNGRVATQLVVSIRVEGDKRLSSLRRCCALTRY 389

Human   391 DAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVP 455
            ||||||.|||..|:||||||:|||||||||||||||||||||||.:.||||.|||||....||||
  Rat   390 DAHKMSQDAFATIRNCNTSGVQTEWSPPLTMLFLCATKFSASAPPACTDITVFLSSDSGCQPKVP 454

Human   456 VTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPF 520
            ..||..:||..|||...:|:|.|||||||||||:||:::|.|.    .|.:..:..|.|||||.|
  Rat   455 AASSGTRTQEPGPAAPTSKEAATSLESFFQKAAKRQRMRETSF----VPPKVAVEKSSSKPSLLF 515

Human   521 QTSQSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLE 585
            |||.|.||:.|||||||||:..:|:|::...|   |.::....|:.|||:.......||.|.| .
  Rat   516 QTSGSPGTKSFFKQKSLLLQHTELSNAAAPCP---PQASSAVQPSRLPTDRADSRASCEEVCK-P 576

Human   586 ESSKATPAEMDLAHNSQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEH 650
            .||||...|:::|.||...:.|.      |:||:        ||||||.||||.|||||||||||
  Rat   577 VSSKAVSTEVNVAGNSSLAYNSQ------EMTQR--------AAEDQVLCEKCDSLVPVWDMPEH 627

Human   651 MDYHFALELQKSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFFKPLTH 713
            :|||||||||||||||.:|.||.| .||.|||||||||||.:|||.||.||||||||||||||
  Rat   628 LDYHFALELQKSFLQPCTSKPQAV-PVSPQGKRNPKSPLASSNKRLRPHGMQTLESFFKPLTH 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLH	NP_006493.1	PolY_Pol_eta	10..428	CDD:176456	380/417 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..472		17/30 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..527		14/31 (45%)
		zf_UBZ	631..661	CDD:465769	26/29 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..705		22/27 (81%)
		PIP-box. /evidence=ECO:0000269|PubMed:15149598, ECO:0000269|PubMed:16357261	701..708		6/6 (100%)
Polh	NP_001101674.1	PolY_Pol_eta	10..427	CDD:176456	380/417 (91%)
		zf_UBZ	608..638	CDD:465769	26/29 (90%)