Protein Alignment POLH and eso1

DIOPT Version :10

• Sequence 1: NP_006493.1
• Gene: POLH / 5429
• HGNCID: 9181
• Length: 713
• Species: Homo sapiens
• Sequence 2: NP_596778.1
• Gene: eso1 / 2539666
• PomBaseID: SPBC16A3.11
• Length: 872
• Species: Schizosaccharomyces pombe
• Alignment Length: 740
• Identity: 183/740 - (24%)
• Similarity: 296/740 - (40%)
• Gaps: 208/740 - (28%)

Human     7 RVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKL 71
            ||||.:|.|.|:.|||..:.....:.|.||.|::     |:|||:|.|||..::|.....:|||.
pombe    27 RVVAHIDQDAFYAQVESVRLGLDHSVPLAVQQWQ-----GLIAVNYAARAANISRHETVTEAKKK 86

Human    72 CPDLLLAQVR-----ESRGKAN-----------LTKYREASVEVMEIMSRFA-VIERASIDEAYV 119
            ||:|..|.|:     ||..|.:           |..||..||:::.|:.:.| |:::|||||.::
pombe    87 CPELCTAHVKTWKAGESEAKYHENPNPNYYKTCLDPYRHESVKILNIIKKHAPVVKKASIDECFI 151

Human   120 DLTSAVQERLQKLQGQPISADLLPSTYIE-GLPQGP----------TTAEETVQ--KEGMRKQGL 171
            :|||.|:..:  |:..|...  :||.... .|||.|          ...||.|.  ||...:
pombe   152 ELTSDVKRIV--LEEYPYLK--IPSEDSNVALPQAPVLLWPAEFGMVIEEEVVDRTKEDYER--- 209

Human   172 FQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQT 236
             .|           .|:.|...|.||:|:|..|..:..:.||||:|.|.:|:||....||||:||
pombe   210 -DW-----------DDVFLFYAAKIVKEIRDDIYLQLKYTCSAGVSFNPMLSKLVSSRNKPNKQT 262

Human   237 LVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAM 301
            :::..::......:.|..||.||||.|..:|.:||.:.:.::...:...|....|:.||..::.:
pombe   263 ILTKNAIQDYLVSLKITDIRMLGGKFGEEIINLLGTDSIKDVWNMSMDFLIDKLGQTNGPLVWNL 327

Human   302 CRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQL 366
            |.||::..:..:...|::..:|||..:...:..:.:.|:.: .|.:|..|..:
pombe   328 CHGIDNTEITTQVQIKSMLSAKNFSQQKVKSEEDAINWFQV-FASDLRSRFLE------------ 379

Human   367 VVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSA 431
                       |..:||                                  |.|   :|.|.
pombe   380 -----------LEGMRR----------------------------------PKT---ICLTV--- 393

Human   432 SAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEA 496
                    ::.||....||  ::|: :.:..||.   .|.||.|....|:..|.
pombe   394 --------VSRFLRKSRSS--QIPM-NVDISTQF---IVEATSKLLRQLQQEFD----------- 433

Human   497 SLSSLTAPTQAPMSNSPSKPSLPFQT-----SQSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNP 556
                     ..|:||.    |:.||.     ..|.|.|.|.|:.:    .:...::|||
pombe   434 ---------VYPISNL----SISFQNIIEVDRNSRGIEGFLKKSN----DEIYMSTSVS------ 475

Human   557 WSNCKALPNSLPTEYPGCVPVCEGVSKL------EESSKATPAEMDLAHNSQSMHASSASKSVLE 615
                               |..||.:||      |.:|....:|.|:  .|.........|.:.:
pombe   476 -------------------PSIEGRAKLLNENMRENNSFELSSEKDI--KSPKRLKRGKGKGIFD 519

Human   616 VTQK-ATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMDYHFALELQK-----SFLQPHSSNPQVV 674
            :.|: |...|:..:|::...||:|...:.:.:..||.|||.||.:.:     :.:.|....|:.|
pombe   520 MLQQTAVSKPTENSADETYTCEECEQKITLSERNEHEDYHIALSISRKERYNNLVPPSHDKPKQV 584

Human   675 SAVSHQGKRNPK--SPLA--CTNKR 695
            ...::..|...|  :||:  ..|||
pombe   585 KPKTYGRKTGSKHYAPLSDETNNKR 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLH	NP_006493.1	PolY_Pol_eta	10..428	CDD:176456	117/447 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..472		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..527		7/36 (19%)
		zf_UBZ	631..661	CDD:465769	10/29 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..705		7/23 (30%)
		PIP-box. /evidence=ECO:0000269|PubMed:15149598, ECO:0000269|PubMed:16357261	701..708
eso1	NP_596778.1	PolY_Pol_eta	30..446	CDD:176456	136/541 (25%)
		zf_UBZ	536..567	CDD:465769	10/30 (33%)
		zf-C2H2_3	643..679	CDD:464013
		Acetyltransf_13	797..853	CDD:464015