DRSC/TRiP Functional Genomics Resources

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Protein Alignment POLG and MIP1

DIOPT Version :10

Sequence 1:NP_002684.1 Gene:POLG / 5428 HGNCID:9179 Length:1239 Species:Homo sapiens
Sequence 2:NP_014975.2 Gene:MIP1 / 854508 SGDID:S000005857 Length:1254 Species:Saccharomyces cerevisiae


Alignment Length:1183 Identity:410/1183 - (34%)
Similarity:596/1183 - (50%) Gaps:257/1183 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    70 RHNPLDIQMLSRGLHEQIFGQ-GGEMPGEAA---VRRSVEHLQKHGLWGQPAVPLPDVELRLPPL 130
            |.||:.||.|...|..|:||. ||:...|.:   :..|.:.|:.|||||:..:....:...||||
Yeast    40 RINPVGIQYLGESLQRQVFGSCGGKDEVEQSDKLMELSKKSLKDHGLWGKKTLITDPISFPLPPL 104

Human   131 YGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERAL 195
            .|.:||:||:.:.:..|.||........ .::..:|..|....||.:|.|....|.||.|:|..:
Yeast   105 QGRSLDEHFQKIGRFNSEPYKSFCEDKF-TEMVARPAEWLRKPGWVKYVPGMAPVEVAYPDEELV 168

Human   196 VFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRD 260
            |||||........||||.|:|.:|||.|||..:       .....||.||||....         
Yeast   169 VFDVETLYNVSDYPTLATALSSTAWYLWCSPFI-------CGGDDPAALIPLNTLN--------- 217

Human   261 WQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPP 325
             :||:::||||::|||.:.|:|..:.|:..||||.|:|:|..||.|.||.:::  |..|.|    
Yeast   218 -KEQVIIGHNVAYDRARVLEEYNFRDSKAFFLDTQSLHIASFGLCSRQRPMFM--KNNKKK---- 275

Human   326 TKQGQKSQRKARRGPAISSWD----WLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIR 386
                 :::.::...|.||..|    ||::|::|||.:|.:.:. ...|:|..|:.|.......|.
Yeast   276 -----EAEVESEVHPEISIEDYDDPWLNVSALNSLKDVAKFHC-KIDLDKTDRDFFASTDKSTII 334

Human   387 ENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQN-WERYLAEAQG 450
            ||||.|:.|||.||.||.:||.:..|:||::|||||:.||:..:....||...| |..||..::.
Yeast   335 ENFQKLVNYCATDVTATSQVFDEIFPVFLKKCPHPVSFAGLKSLSKCILPTKLNDWNDYLNSSES 399

Human   451 TYEELQREMKKSLMDLANDACQLL-SGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLP 514
            .|::.:.:::..::.:..|...|. ..:.|.:||||..|:|..:..:..|               
Yeast   400 LYQQSKVQIESKIVQIIKDIVLLKDKPDFYLKDPWLSQLDWTTKPLRLTK--------------- 449

Human   515 IEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPR 579
                                                  ||    :|.:.|.|||.|.|||:|.|.
Yeast   450 --------------------------------------KG----VPAKCQKLPGFPEWYRQLFPS 472

Human   580 LDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAG 644
            .|    |..|. ::::.|:.|.|..|:|:..|:.:|:..||.:.|                    
Yeast   473 KD----TVEPK-ITIKSRIIPILFKLSWENSPVIWSKESGWCFNV-------------------- 512

Human   645 VVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLR 709
               |:..:|: |:                  |:.::|.|:.:           :.|.|.:..||.
Yeast   513 ---PHEQVET-YK------------------AKNYVLADSVS-----------QEEEEIRTHNLG 544

Human   710 AAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKM 774
            ....|.                                 .||:||.:|.:.|..:...|.:....
Yeast   545 LQCTGV---------------------------------LFKVPHPNGPTFNCTNLLTKSYNHFF 576

Human   775 EDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALP--------RAVIRHPDY 831
            |.|.|::....|.  :||:||...|:|.:|.:||.||.||  |....|        ::.:.:...
Yeast   577 EKGVLKSESELAH--QALQINSSGSYWMSARERIQSQFVV--PSCKFPNEFQSLSAKSSLNNEKT 637

Human   832 DEEGLYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQEL 896
            ::..:   |:|::|..|||||||||..|||||||:.:|:|||||..|:|||||..|||||||:||
Yeast   638 NDLAI---IIPKIVPMGTITRRAVENAWLTASNAKANRIGSELKTQVKAPPGYCFVGADVDSEEL 699

Human   897 WIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPF 961
            |||:::||:.| .:||.||.|||.|:|.|:.|||||:|||..:|.||..|||||||||||||..|
Yeast   700 WIASLVGDSIF-NVHGGTAIGWMCLEGTKNEGTDLHTKTAQILGCSRNEAKIFNYGRIYGAGAKF 763

Human   962 AERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLR 1026
            |.:||.:||..||.:|..:.|.::|..|||                                   
Yeast   764 ASQLLKRFNPSLTDEETKKIANKLYENTKG----------------------------------- 793

Human  1027 KVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQ-E 1090
                :|.|...:||:       |.||:||.:||||||||..:.|:||||||.|:.:|....:: .
Yeast   794 ----KTKRSKLFKKF-------WYGGSESILFNKLESIAEQETPKTPVLGCGITYSLMKKNLRAN 847

Human  1091 EFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQI 1155
            .|:.||:||.:|||.||||||:..:|:::.:::.::.|.|||||||:|:||.|:|:||||:||||
Yeast   848 SFLPSRINWAIQSSGVDYLHLLCCSMEYIIKKYNLEARLCISIHDEIRFLVSEKDKYRAAMALQI 912

Human  1156 TNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDI 1220
            :|:.||.||..::|:|:|||:.||||.||||..:||||.|||.||||.|      .||.||||||
Yeast   913 SNIWTRAMFCQQMGINELPQNCAFFSQVDIDSVIRKEVNMDCITPSNKT------AIPHGEALDI 971

Human  1221 YQIIELTKGSLEK 1233
            .|:::.:...|.|
Yeast   972 NQLLDKSNSKLGK 984

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POLGNP_002684.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68
Does not contribute to polymerase and exonuclease enzymatic activities. /evidence=ECO:0000269|PubMed:10827171 43..55
DNApol_Exo 121..414 CDD:465664 104/296 (35%)
Exo I. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268 196..200 3/3 (100%)
Exo II. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268 267..275 4/7 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 318..340 2/21 (10%)
Exo III. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268 395..403 5/7 (71%)
DNA_pol_A 431..>473 CDD:470638 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..531 0/24 (0%)
Accessory-interacting determinant. /evidence=ECO:0000269|PubMed:26056153 510..571 7/60 (12%)
DNA_pol_gammaA 785..1203 CDD:176478 200/426 (47%)
Trigger loop. /evidence=ECO:0000269|PubMed:37202477 858..864 4/5 (80%)
Pol A. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268 887..896 7/8 (88%)
Pol B. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268 943..958 12/14 (86%)
Pol C. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268 1134..1141 4/6 (67%)
MIP1NP_014975.2 DNApol_Exo 95..362 CDD:465664 104/296 (35%)
DNA_pol_gammaA 581..960 CDD:176478 201/432 (47%)
Blue background indicates that the domain is not in the aligned region.

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