DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POLD1 and DNApol-zeta

DIOPT Version :9

Sequence 1:	NP_001295561.1	Gene:	POLD1 / 5424	HGNCID:	9175	Length:	1133	Species:	Homo sapiens
Sequence 2:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster

Alignment Length:	884	Identity:	245/884 - (27%)
Similarity:	387/884 - (43%)	Gaps:	137/884 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   310 LRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPIL---------- 364
            |.:::.::..:.|..:.|:|..|. |:.....:....|:.    .|..:.|..|:
  Fly  1300 LTIITLEVFVSTRGDLQPDPMHDE-IRCLFYAIEHSLPDE----KLPSKACGYIMVNTVQDLLSE 1359

Human   365 --------GAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFL 421
                    ..:||....|.:..:|........|.|:..||.|:.....|:|.||:.|.....|.|
  Fly  1360 GPFHGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLL 1424

Human   422 GRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQK 486
            .||.  ...:||...:.::........:.:.||:.:|:.:::..|..|.|||...|.:|.|  .|
  Fly  1425 SRVP--TQKVRDFVDEDREQFTDLDVEMKLCGRILLDVWRLMRSEIALTSYTFENVMYHIL--HK 1485

Human   487 EDVQHSI--ITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSR 549
            ....|:.  :|: ..|:..||..:..|.|:.....|.||::|.:|....|||::.|:....:|||
  Fly  1486 RCPWHTAKSLTE-WFGSPCTRWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSR 1549

Human   550 GQQVKVVSQLLRQAMHEGL--LMPVVKSEG---GEDYTGATVIEPLKGVRPQDRAGAAWELLALT 609
            |.|.:|.|.:||.|..:.|  |.|.|::..   ..:|. |.::||
  Fly  1550 GSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYL-ALIMEP-------------------- 1593

Human   610 PGRGCSPPRYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLG----------------- 657
                  ..|:|..|:..|||.|||||:::|:|.|::|.|  |..:.||
  Fly  1594 ------QSRFYADPLIVLDFQSLYPSMIIAYNYCFSTCL--GRVEHLGGSSPFEFGASQLRVSRQ 1650

Human   658 -----LTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAK--AELAKETDPLRRQVLDGR 715
                 |..|....:|.|..|||..||:|:||::|..:|..|:..|  .:|.|::..|:| :|..|
  Fly  1651 MLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQR-ILHSR 1714

Human   716 QLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVY 779
            ||.||:.||..||:|.|.. |::|.:|:..||...||:.:|:..:|      |||......:|||
  Fly  1715 QLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKL------VENNEEWKVRVVY 1773

Human   780 GDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRP 844
            |||||:.......:.|||..:|.|.|..|:...|.|::|:.||||.|.:|.:||||.|.::.:..
  Fly  1774 GDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETAD 1838

Human   845 DAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVI 909
            ......:.||:|.||||.||.||.::...||.|...:|.....|:.....:.||..|.::..|:.
  Fly  1839 QEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIF 1903

Human   910 TKELTRAASDYAGKQA--HVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVL 972
            .||. |..:.|.....  .:||..:..::||...|..|:|||::|::...|:........|..:|
  Fly  1904 AKEF-RGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDIL 1967

Human   973 -EHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTR-------CKTVLTGKVGGLL 1029
             .....|:..||:.:.:..||.|            .:||.|.:..       .|.::|..||...
  Fly  1968 ANEGHKINAIYYITKAIIPPLNR------------CLLLIGANVHDWFASLPRKLLMTPAVGTAN 2020

Human  1030 AFAKRR-------------NCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRLW 1081
            ..|..|             :|.|.|..  ..:..:|..|. :.:......:|...|..||..:|.
  Fly  2021 ELAGARGAKSTISQYFSTTSCVIDCGR--QTKAGICPDCL-KNATTCVVVLSDKTARLERGYQLT 2082

Human  1082 TQ-CQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQE 1119
            .| ||.|.|.| ..:.|.|.|||:.|:.:..|::|:..|
  Fly  2083 RQICQACCGRL-GSLQCDSLDCPVLYVLEGKRRELQQIE 2120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POLD1	NP_001295561.1	PTZ00166	81..1126	CDD:240301	245/884 (28%)
		DNA_polB_delta_exo	304..533	CDD:99820	54/242 (22%)
		POLBc_delta	579..1000	CDD:99916	139/448 (31%)
		zf-C4pol	1038..1108	CDD:290959	21/70 (30%)
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	49/227 (22%)
		POLBc_zeta	1550..2000	CDD:99917	153/498 (31%)
		zf-C4pol	2041..2107	CDD:405022	21/69 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820