Protein Alignment ATP7B and ATP7

DIOPT Version :10

• Sequence 1: NP_000044.2
• Gene: ATP7B / 540
• HGNCID: 870
• Length: 1465
• Species: Homo sapiens
• Sequence 2: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Alignment Length: 1234
• Identity: 577/1234 - (46%)
• Similarity: 771/1234 - (62%)
• Gaps: 143/1234 - (11%)

Human   258 TLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGN 322
            |::|.|.||.|:|||.||.|:|||..|:..::|.||.......|||..|.|..:...|:.:   .
  Fly    13 TVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDM---G 74

Human   323 FKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGV 387
            |:.|.|    |...|           ||.....   :.|.|.:.||||.|||.:|||.|....|:
  Fly    75 FECSYP----GDAAD-----------PPETPAS---AWTNIRVVGMTCQSCVRNIEGNIGTKPGI 121

Human   388 QQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVV---SESCSTNPLGNHSAGNSMVQTT 449
            ..|.|.||...|.|.|:|:...|.::...|:||||||||.   |.|.|.:|    :..:|..:..
  Fly   122 HSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSP----APASSPKKRA 182

Human   450 DGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVA-P------QKCFLQIKGMTCASCVSNIE 507
            ..||.            |.::|        |:..||| |      .||||.|:||||||||:.||
  Fly   183 TPTPP------------PPSYA--------QNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIE 227

Human   508 RNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITG 572
            ::.:|..|:.|:||||:|.|||:|::..|:....||:.|.:|||...::::....:..:||.|.|
  Fly   228 KHCKKIYGLDSILVALLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMG 292

Human   573 MTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASL-AQRNP 636
            |||||||:.|||.:.:..|:|.|||.|.|.:...::..|..|||.|.:.||.:||.|.| ..|:.
  Fly   293 MTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDK 357

Human   637 NAH-HLDHKMEIKQWKKSFLCSLVFGIPVMALMIY-MLIPSNEPHQSMVLDHNIIPGLSILNLIF 699
            .|| :|:||.||::|:.:||.||:||.|.|..||| ||..|::.|.:|..   ::||||:.||:.
  Fly   358 MAHNYLEHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMCC---LVPGLSMENLVM 419

Human   700 FILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFF 764
            |:|.|.||..||::||||:|::::|.:.||||||.:.|:|:||||:.:::.||..:...||:|||
  Fly   420 FLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFF 484

Human   765 DTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGD 829
            ||||||.:||:|||||||:||.||||||:||:||:|.:|.:|.:..|..||.|:.:.::.|||||
  Fly   485 DTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGD 549

Human   830 IVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDT 894
            |:||:||.|.|||||||.|::..||||||||:|||.|:.||.||.||||.:|.:|::|||.|.:|
  Fly   550 ILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENT 614

Human   895 TLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPN- 958
            ||||||:||||||.|||||||||||.:||||||::::|::||:.||:||          |.|||
  Fly   615 TLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIG----------FSNPNL 669

Human   959 --------KHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPL 1015
                    .|:.|..:|:.:||:.:::||.|||||:|||||||||||.||..|.||:|:||...|
  Fly   670 VPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATAL 734

Human  1016 EMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK 1080
            |.|||:|||:||||||||||.|...:|.|........|.:.|.:||.||.:||||:..|:..:.|
  Fly   735 ENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAK 799

Human  1081 EELG------TETLGYCTDFQAVPGCGIGCKVSNVEGIL---AHSERPLSAPASH-LNEAGSLPA 1135
            :.|.      ..:.|..:.|||||||||...|||.|..|   .:::|.::....| .:..||:|.
  Fly   800 DMLNVGATPQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPV 864

Human  1136 EKDA-----VPQ------------------------------------TFSVLIGNREWLRRNGL 1159
            :..|     :||                                    ...||||||||:.||.:
  Fly   865 DNGASIEHLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAI 929

Human  1160 TISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNR 1224
            .:..::||.||..|.||.||:|.|::|.|..|.|::|.||.||.|||:||:.||:||||:||||:
  Fly   930 EVPLEISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNK 994

Human  1225 KTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTD 1289
            .||.:||.:|||..|:|||||||||||:|.:|..|.:||||||||||||||||||:|:.|..|||
  Fly   995 NTAASIAREVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTD 1059

Human  1290 VAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWM 1354
            ||.||:|:||:|||||||||.:.||:.||||||.|...|.:|||:|||:|:|:|.|.|..|.|||
  Fly  1060 VAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWM 1124

Human  1355 GSAAMAASSVSVVLSSLQLKCYKKPDLE-----RYEAQ-----AHGHMKPLTASQVSVHIGMDD 1408
            .|.||||||||||.|||.||.|:||..:     .||||     |.|....|  .::|:|.|:||
  Fly  1125 ASVAMAASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDEL--DKLSLHRGLDD 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7B	NP_000044.2	HMA	61..124	CDD:238219
		HMA	146..209	CDD:238219
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..249
		HMA	260..318	CDD:238219	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..355		7/32 (22%)
		HMA	363..425	CDD:238219	28/61 (46%)
		HMA	492..554	CDD:238219	31/61 (51%)
		HMA	567..630	CDD:238219	30/62 (48%)
		P-type_ATPase_Cu-like	652..1354	CDD:319783	391/762 (51%)
ATP7	NP_572756.3	CopZ	11..76	CDD:442020	25/65 (38%)
		HMA	97..159	CDD:238219	28/61 (46%)
		chaper_CopZ_Eh	212..276	CDD:411374	31/63 (49%)
		HMA	287..350	CDD:238219	30/62 (48%)
		P-type_ATPase_Cu-like	376..1130	CDD:319783	395/766 (52%)