DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP7B and ccc2

DIOPT Version :9

Sequence 1:	NP_000044.2	Gene:	ATP7B / 540	HGNCID:	870	Length:	1465	Species:	Homo sapiens
Sequence 2:	NP_595829.1	Gene:	ccc2 / 2540525	PomBaseID:	SPBC29A3.01	Length:	904	Species:	Schizosaccharomyces pombe

Alignment Length:	1045	Identity:	350/1045 - (33%)
Similarity:	533/1045 - (51%)	Gaps:	217/1045 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   360 TTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEA 424
            ||.:::.||||.|||.||:.|:..:||::|.::||....|..:::||:|||:::...|||.||:|
pombe     3 TTTLSVQGMTCTSCVASIQSMLEGVEGIEQFTISLLLERAIAVHDPSIISPDQIAEKIEDCGFDA 67

Human   425 SVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQK 489
            ||:|                   :|:|
pombe    68 SVIS-------------------STEG-------------------------------------- 75

Human   490 CFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAA 554
                                   |.||::..:              ::.|::..|:.:
pombe    76 -----------------------EHGVMANYL--------------LLSPMQAEQWTK------- 96

Human   555 VMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKAL-VKFDPEIIGPRDI 618
                                    |||   .:....|:...:.:.:...|: |.:|.||.|||.|
pombe    97 ------------------------VHN---HINELQGVLSVNCSSSPDAAIRVIYDSEITGPRSI 134

Human   619 IKIIEEIGFHASLAQRNPNAHH---LDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQ 680
            :|.|..:|...:....:.:...   |....:|:.||..|:.|:.|.:.||.|.  .:..|.:..:
pombe   135 MKEILSMGVKCTFQPVDSSTSRILSLQRGSQIRVWKIRFIISISFSLAVMFLP--QIFDSCDSMR 197

Human   681 SMVLDHNIIP---GLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYV 742
            :..|    :|   |:...::|..:|...||...|..:|..||.:|:..:||||||:.|.:::|:.
pombe   198 AAFL----VPHYFGICAGHIISLVLSLPVQFGVGRVYYSAAYHALKRGTANMDVLVSLGSTVAFA 258

Human   743 YSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVT 807
            .|:..:::..|..|:.....||||..||..|:.|||:||..||..||.||::|:||..:.||::
pombe   259 ASIFFMILYSARHADNPAPIFFDTADMLLTFVTLGRYLESKAKGSTSAALSQLLSLAPSSATII- 322

Human   808 LGEDNLIIREEQVPM--ELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGS 870
              |||     ||:.:  :|::|||::.|.||...||||.|:||::..|||.::||.:||.|....
pombe   323 --EDN-----EQIEILADLIERGDLILVKPGEIIPVDGTVVEGSSYVDESSVSGEPVPVHKTIDD 380

Human   871 TVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLT 935
            .:::|:.|.:|.:|:|||....::.||.||.||:.||:|.|||||.|||.:|.|||.|:.:|..|
pombe   381 ELLSGTANGNGRLLVKATKSPRESQLAVIVDLVQRAQISHAPIQQFADRVAGIFVPVIVALSIST 445

Human   936 LVVWIVIGFIDFGVVQRY---FPNPNKHISQTEVIIRFA--FQTSITVLCIACPCSLGLATPTAV 995
            ...|.:  |..:.  .:|   |.:|         :.:||  .:.:|:|:.:||||:|||:|||||
pombe   446 FTFWFL--FTKYS--SKYPSVFDDP---------MGKFAVCLKLTISVVVVACPCALGLSTPTAV 497

Human   996 MVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLL---LGDVATLPLRKVL 1057
            ||||||.|.|||:||||:.||..:::.||:||||||:|.|...|..:.:   |.::..:|.....
pombe   498 MVGTGVGALNGIIIKGGEILERLNQVDTVVFDKTGTLTVGKLSVTDISIVDNLEELLDIPKNIFW 562

Human  1058 AVVGTAEASSEHPLGVAVTKYCKE-----ELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSE 1117
            |.|..:|:|||||:|.|:|:...|     |:|.|:      |.||||.|       |:.:|...|
pombe   563 AFVKASESSSEHPIGKAITEKASEFTDVSEIGIES------FNAVPGEG-------VDVVLRWKE 614

Human  1118 RPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILV 1182
            |                        ||..|:||...|..|.::|..|....:......|.|.:.:
pombe   615 R------------------------TFHALLGNSLLLEHNNVSIPDDFDSKLKLSSSSGLTCVRI 655

Human  1183 AIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIA--TQVGINKVFAEVLP 1245
            ||||...|.:...|.|:.::...|..|:.:|..|.|:|||.:.|||.:|  .::..:.|:||.:|
pombe   656 AIDGQFVGFLGCMDQVRPDSYQTVSALKQLGKKVCLLTGDQKATARRVAQGLEIDFSDVYAEAVP 720

Human  1246 SHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRND-LLDVVA 1309
            |.|...:|:|:::...|||||||:||||:|..||:|:|...|:.:|:|:|||:|:|.. |||...
pombe   721 SQKAEIIQKLKDQKHCVAMVGDGINDSPSLVLADVGIAPINGSGIALESADVILVRKGVLLDTAV 785

Human  1310 SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLK 1374
            |..||:..|:||::|||.|.|||.|.||||.|.|:|.||.|.|...||||..||:||:.|||.|:
pombe   786 SFDLSRVIVKRIKMNLVWACIYNFVMIPIAMGFFLPWGIYLNPMWASAAMMFSSLSVLASSLLLR 850

Human  1375 CYKKP 1379
            .:|||
pombe   851 RWKKP 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP7B	NP_000044.2	E1-E2_ATPase	769..1016	CDD:278548	112/253 (44%)
		COG4087	<1206..1309	CDD:226572	47/105 (45%)
		HMA	61..124	CDD:238219
		HMA	146..209	CDD:238219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..249
		HMA	260..318	CDD:238219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..355
		HMA	363..425	CDD:238219	26/61 (43%)
		HMA	492..554	CDD:238219	5/61 (8%)
		ZntA	566..1355	CDD:225127	296/813 (36%)
		HMA	567..630	CDD:238219	16/63 (25%)
ccc2	NP_595829.1	ZntA	1..837	CDD:225127	339/1025 (33%)
		HMA	5..68	CDD:238219	26/62 (42%)
		E1-E2_ATPase	285..518	CDD:278548	112/253 (44%)
		COG4087	670..791	CDD:226572	50/120 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	156	1.000	Domainoid score	I1180
eggNOG	1	0.900	-	-		E1_COG2217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I241
OMA	1	1.010	-	-		QHG53773
OrthoFinder	1	1.000	-	-		FOG0001874
OrthoInspector	1	1.000	-	-		otm53733
orthoMCL	1	0.900	-	-		OOG6_100289
Panther	1	1.100	-	-	LDO	PTHR43520
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R123
SonicParanoid	1	1.000	-	-		X1231
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860