Protein Alignment A4GALT and alpha4GT2

DIOPT Version :10

• Sequence 1: NP_059132.1
• Gene: A4GALT / 53947
• HGNCID: 18149
• Length: 353
• Species: Homo sapiens
• Sequence 2: NP_651434.3
• Gene: alpha4GT2 / 43124
• FlyBaseID: FBgn0039378
• Length: 395
• Species: Drosophila melanogaster
• Alignment Length: 322
• Identity: 95/322 - (29%)
• Similarity: 148/322 - (45%)
• Gaps: 25/322 - (7%)

Human    47 KEKGQLYNLPAEIPCPTLTPPTPPSHGPTPG-NIFFLETSD--RTNPNFLFM------CSVESAA 102
            :.|.:|..:..:||...|.........|:.| ||||.||::  |...:.:..      |::||||
  Fly    74 QSKFKLDKVSKKIPVIPLLDVLKAKKQPSRGQNIFFHETTNFKRIEKSSVVQLTAREACAIESAA 138

Human   103 RTHPESHVLVLMKGL---PGGNASLPRHLGISLLSCFPNVQMLPLDLRELFRDTPLADWYAAVQG 164
            ..:|...|.||..|.   |.....|     |..|..:.|:::..|:|......||:|.|..:.:.
  Fly   139 LHNPGLTVFVLFAGATHRPSSGDPL-----IRALHNYKNIRLRHLNLWRYAAGTPIAKWLKSGKL 198

Human   165 RWEPYLLPVLSDASRIALMWKFGGIYLDTDFIVLKNLRNL-TNVLGTQSRYVLNGAFLAFE---R 225
            ....:|.|.:||..|...::|:||:|||.|.:|.:||..| .|..|.:|...:....:...   .
  Fly   199 FKSKFLFPHVSDLLRYVSLYKYGGLYLDLDVVVQQNLEKLPPNFTGAESNISVACGVMKMSPGGL 263

Human   226 RHEFMALCMRDFVDHYNGWIWGHQGPQLLTRVFKKWC---SIRSLAES-RACRGVTTLPPEAFYP 286
            .|:...:|:||...:||...||..||.::|||.||.|   :|:|:..: :.|.|.......|||.
  Fly   264 GHKIATMCLRDLEANYNANKWGTNGPGVITRVVKKQCNTDNIKSVINNPKRCNGFKVFDANAFYA 328

Human   287 IPWQDWKKYFEDINPEELPRLLSATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHEA 348
            |.|..||.:|:........:.:|.:..:|||||.|:|.:.:..|......|...:||.:..|
  Fly   329 ISWLQWKDFFQPNRHNVTMKRVSKSPVIHVWNKFSKGWKVKTKSNCAYTTLAKIHCPRSFAA 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
A4GALT	NP_059132.1	Gly_transf_sug	94..214	CDD:418730	40/129 (31%)
		DXD motif. /evidence=ECO:0000250	192..194		1/1 (100%)
		Gb3_synth	222..349	CDD:428017	41/134 (31%)
alpha4GT2	NP_651434.3	Gly_transf_sug	129..241	CDD:418730	37/116 (32%)
		Gb3_synth	262..391	CDD:428017	41/129 (32%)