DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DUOX1 and cd

DIOPT Version :9

Sequence 1:NP_059130.2 Gene:DUOX1 / 53905 HGNCID:3062 Length:1551 Species:Homo sapiens
Sequence 2:NP_651081.1 Gene:cd / 42681 FlyBaseID:FBgn0263986 Length:830 Species:Drosophila melanogaster


Alignment Length:638 Identity:178/638 - (27%)
Similarity:276/638 - (43%) Gaps:131/638 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    30 QRFDGWYNNLMEHR-WGSKGSRLQRLVPASYADGVYQPLGEPH--LPNPRDLSNTISRGPAGLAS 91
            :|..|..||....| :|:.....:|:|...||||:..|....|  ||..|.:|..|.|......|
  Fly   219 RRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAAPRVSHHGRLPPARQVSLKIHRSSYETDS 283

Human    92 LRNRTVLGVFFGYHVLSDLVSV--------------------ETPGC-PAEFLNIRIPPGDPMFD 135
              |.||:...||..:..|:.:.                    :.|.| |.:.|     |.||.: 
  Fly   284 --NFTVMLAVFGQFMDHDITATSLTTSQEGESIDCCVAATREQHPECYPVDIL-----PDDPYY- 340

Human   136 PDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASG 200
             .|.....:.|.||...| |||  ..||...||.|.::|.|.:||:.....:.||||..|.|.  
  Fly   341 -KQYNISCMNFVRSAPAP-TGR--FGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFINGSLR-- 399

Human   201 PDPAFPRDSQNPLLMWAAPDPATGQNGPR----GLYAF--GAERGNREPFLQALGLLWFRYHNLW 259
               .|..|....||. .:.:||.|.|..:    |.|.|  |.:|.|....|.::.|||.|:||..
  Fly   400 ---MFVTDDGRQLLP-ISSNPADGCNRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYL 460

Human   260 AQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTG-------------YR 311
            |::|..|:|.||||.|:|.|||.:.|...:|...|:||..|.|.:.|..|             |.
  Fly   461 ARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDTYD 525

Human   312 PFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCN------SYWSR 370
            |.:||||::.|.||:.:|..|:: ||::.          |:|::|...|:.:..      |.|: 
  Fly   526 PEVDPSIANCFAAAAFRFAHTLL-PGLFN----------ISRDNSTPEAIELHKMLFNPFSLWA- 578

Human   371 EHPSLQSAEDVD-ALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASC--------LQR 426
            ||       .:| ||:....:.:.:.:....:|..:..:.|    :..|.:..|        :||
  Fly   579 EH-------GIDHALMTAANTPVMQVDRFFSLEVTQKLFEG----TAEDRVPLCGLDLVSLNIQR 632

Human   427 GRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYN--QDLSWLELLPGGLLES 489
            |||.|:|||...|....|..:..|::::.|:   ::..|::...:|.  ||   :::..|.|.|.
  Fly   633 GRDHGIPSYPVFRRHCRLPTVDTWEEMSQAI---DNATLDSIRQIYESPQD---VDVYTGALSEP 691

Human   490 HRDP---GPLFSTIVLEQFVRLRDGDRYWFENTRN-GLFSKKEIEEIRNTTLQDVLV----AVIN 546
            ..|.   |||.|.:|.:||:||:.||.:|:|.... ..|:|.::.||..|:|..::.    .:..
  Fly   692 PLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITR 756

Human   547 IDPSALQ-------PNV---------FVWHKGDPCPQPRQLSTEGLPACAPSV 583
            :....:|       |:|         |.:.......||:.|.:.|:...:.||
  Fly   757 VREHVMQRLRDGGNPHVDCQDLEGFHFNFEPWSEKQQPQDLHSAGISRGSTSV 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUOX1NP_059130.2 Peroxidase-like, mediates peroxidase activity 26..593 178/638 (28%)
An_peroxidase 30..544 CDD:281139 168/581 (29%)
dual_peroxidase_like 32..591 CDD:188652 177/636 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..172 9/21 (43%)
EFh 820..881 CDD:238008
EF-hand_7 820..880 CDD:290234
EF-hand_7 857..921 CDD:290234
EFh 857..915 CDD:238008
Interaction with TXNDC11. /evidence=ECO:0000250 956..1248
Ferric_reduct 1091..1226 CDD:280043
NOX_Duox_like_FAD_NADP 1277..1551 CDD:99783
cdNP_651081.1 An_peroxidase 218..755 CDD:281139 168/582 (29%)
peroxinectin_like 364..750 CDD:188655 125/420 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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