DRSC/TRiP Functional Genomics Resources

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Protein Alignment DUOX1 and Pxt

DIOPT Version :9

Sequence 1:NP_059130.2 Gene:DUOX1 / 53905 HGNCID:3062 Length:1551 Species:Homo sapiens
Sequence 2:NP_650648.3 Gene:Pxt / 42131 FlyBaseID:FBgn0261987 Length:809 Species:Drosophila melanogaster


Alignment Length:632 Identity:168/632 - (26%)
Similarity:251/632 - (39%) Gaps:137/632 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    17 TPLG--AQNP-----ISWEVQRFDGWYNNLMEHR--WGSKGSRLQRLVPASYADGVYQPL----- 67
            |||.  .|.|     |....:..||..||....|  ||:.|..::|::|.:|.||::.|.     
  Fly   218 TPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSD 282

Human    68 GEPHLPNPRDLSNTISRGPAGLASLRNR-----TVLGVFFGY---HVLSDLVSVETPG------C 118
            |.| |...|.:|.|       |.|..:|     .::.:.||.   |.:|...|:....      |
  Fly   283 GTP-LLGARKISRT-------LLSDVDRPHPKYNLMVMQFGQVLAHDISQTSSIRLEDGSLVQCC 339

Human   119 PAE-------------FLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQ-- 168
            ..|             .:.|.:.|.|..|  ...|...|.|.|....|    ||........|  
  Fly   340 SPEGKVALSPQQSHFACMPIHVEPDDEFF--SAFGVRCLNFVRLSLVP----SPDCQLSYGKQLT 398

Human   169 -VTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLL--MWAAPDPATGQNGPRG 230
             ||.::|.|.:||||...|.:||:|..|:|....|  |.||.. ||.  ..|.|....|    :.
  Fly   399 KVTHFVDASPVYGSSDEASRSLRAFRGGRLRMMND--FGRDLL-PLTNDKKACPSEEAG----KS 456

Human   231 LYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEW 295
            .:..|..|.|:...|..|.:|..|.||..|..|...:|...||.|||.||:.|||..|:|...|:
  Fly   457 CFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEF 521

Human   296 LPSFLQ-------KTLPEYTG----YRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQG 349
            ||..:.       :.:|.:.|    |...::|:|::||..|:.:...:.|.....:|........
  Fly   522 LPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQIRQEHGRIDE 586

Human   350 VINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDF-WPGPLK 413
            |:|....:....|            ::..|..|.:|..:.||..::.|..:.:.:..| :.|...
  Fly   587 VVNIPDVMFNPSR------------MRKREFYDDMLRTLYSQPMQQVDSSISQGLSRFLFRGDNP 639

Human   414 FSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQ----DINPALSRSNDTVLEATAALYNQ 474
            |. .|..|..:|||||.||.||......:|...:..::    :|...|||...|..:        
  Fly   640 FG-LDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFPIEIAQKLSRVYRTPDD-------- 695

Human   475 DLSWLELLPGGLLESHRDPGPL---FSTIVLEQFVRLRDGDRYWFE--NTRN-GLFSKKEIEEIR 533
                ::|..|||||...:.|.:   |:.|:.:||.|.:.||||::|  |..| |.|:..:::|||
  Fly   696 ----IDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQLQEIR 756

Human   534 NTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACA 580
            ..||..:|                       |....:|:.:.:|..|
  Fly   757 KVTLARLL-----------------------CDNSDRLTLQAVPLAA 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUOX1NP_059130.2 Peroxidase-like, mediates peroxidase activity 26..593 162/616 (26%)
An_peroxidase 30..544 CDD:281139 158/574 (28%)
dual_peroxidase_like 32..591 CDD:188652 162/610 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..172 6/24 (25%)
EFh 820..881 CDD:238008
EF-hand_7 820..880 CDD:290234
EF-hand_7 857..921 CDD:290234
EFh 857..915 CDD:238008
Interaction with TXNDC11. /evidence=ECO:0000250 956..1248
Ferric_reduct 1091..1226 CDD:280043
NOX_Duox_like_FAD_NADP 1277..1551 CDD:99783
PxtNP_650648.3 GH64-TLP-SF <67..119 CDD:295337
An_peroxidase 237..772 CDD:281139 159/603 (26%)
peroxinectin_like 396..767 CDD:188655 118/425 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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