DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DUOX1 and Pxt

DIOPT Version :10

Sequence 1:NP_059130.2 Gene:DUOX1 / 53905 HGNCID:3062 Length:1551 Species:Homo sapiens
Sequence 2:NP_650648.3 Gene:Pxt / 42131 FlyBaseID:FBgn0261987 Length:809 Species:Drosophila melanogaster


Alignment Length:632 Identity:168/632 - (26%)
Similarity:251/632 - (39%) Gaps:137/632 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    17 TPLG--AQNP-----ISWEVQRFDGWYNNLMEHR--WGSKGSRLQRLVPASYADGVYQPL----- 67
            |||.  .|.|     |....:..||..||....|  ||:.|..::|::|.:|.||::.|.     
  Fly   218 TPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSD 282

Human    68 GEPHLPNPRDLSNTISRGPAGLASLRNR-----TVLGVFFGY---HVLSDLVSVETPG------C 118
            |.| |...|.:|.|       |.|..:|     .::.:.||.   |.:|...|:....      |
  Fly   283 GTP-LLGARKISRT-------LLSDVDRPHPKYNLMVMQFGQVLAHDISQTSSIRLEDGSLVQCC 339

Human   119 PAE-------------FLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQ-- 168
            ..|             .:.|.:.|.|..|  ...|...|.|.|....|    ||........|  
  Fly   340 SPEGKVALSPQQSHFACMPIHVEPDDEFF--SAFGVRCLNFVRLSLVP----SPDCQLSYGKQLT 398

Human   169 -VTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLL--MWAAPDPATGQNGPRG 230
             ||.::|.|.:||||...|.:||:|..|:|....|  |.||.. ||.  ..|.|....|    :.
  Fly   399 KVTHFVDASPVYGSSDEASRSLRAFRGGRLRMMND--FGRDLL-PLTNDKKACPSEEAG----KS 456

Human   231 LYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEW 295
            .:..|..|.|:...|..|.:|..|.||..|..|...:|...||.|||.||:.|||..|:|...|:
  Fly   457 CFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEF 521

Human   296 LPSFLQ-------KTLPEYTG----YRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQG 349
            ||..:.       :.:|.:.|    |...::|:|::||..|:.:...:.|.....:|........
  Fly   522 LPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQIRQEHGRIDE 586

Human   350 VINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDF-WPGPLK 413
            |:|....:....|            ::..|..|.:|..:.||..::.|..:.:.:..| :.|...
  Fly   587 VVNIPDVMFNPSR------------MRKREFYDDMLRTLYSQPMQQVDSSISQGLSRFLFRGDNP 639

Human   414 FSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQ----DINPALSRSNDTVLEATAALYNQ 474
            |. .|..|..:|||||.||.||......:|...:..::    :|...|||...|..:        
  Fly   640 FG-LDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFPIEIAQKLSRVYRTPDD-------- 695

Human   475 DLSWLELLPGGLLESHRDPGPL---FSTIVLEQFVRLRDGDRYWFE--NTRN-GLFSKKEIEEIR 533
                ::|..|||||...:.|.:   |:.|:.:||.|.:.||||::|  |..| |.|:..:::|||
  Fly   696 ----IDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQLQEIR 756

Human   534 NTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACA 580
            ..||..:|                       |....:|:.:.:|..|
  Fly   757 KVTLARLL-----------------------CDNSDRLTLQAVPLAA 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUOX1NP_059130.2 Peroxidase-like, mediates peroxidase activity 26..593 162/616 (26%)
dual_peroxidase_like 32..591 CDD:188652 162/610 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..172 6/24 (25%)
EFh 820..881 CDD:238008
EFh 857..915 CDD:238008
Interaction with TXNDC11. /evidence=ECO:0000250 956..1248
PLN02292 1089..>1412 CDD:215165
NOX_Duox_like_FAD_NADP 1277..1551 CDD:99783
PxtNP_650648.3 An_peroxidase 237..781 CDD:460804 162/613 (26%)
Blue background indicates that the domain is not in the aligned region.

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