DRSC/TRiP Functional Genomics Resources

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Protein Alignment DUOX1 and Irc

DIOPT Version :10

Sequence 1:NP_059130.2 Gene:DUOX1 / 53905 HGNCID:3062 Length:1551 Species:Homo sapiens
Sequence 2:NP_650584.1 Gene:Irc / 42049 FlyBaseID:FBgn0038465 Length:697 Species:Drosophila melanogaster


Alignment Length:578 Identity:148/578 - (25%)
Similarity:232/578 - (40%) Gaps:114/578 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    36 YNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPH-----------------LPN-----PRDL 78
            |.|.....:.:.|.|  ..|||:::  :.:.|.||.                 ||.     ..||
  Fly   163 YRNGFYQMFPNSGRR--ETVPAAWS--ISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDL 223

Human    79 SNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDP-----MFDPDQ 138
            |..:|:.                     :|:...:|.  |..:.:|::.....|     ::.|..
  Fly   224 SKPVSQS---------------------MSNGAPIEC--CSRDQINLQPRHHHPACAPILYQPGG 265

Human   139 RGDV--VLPFQRSRW---DPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLA 198
            :.||  .|.:.||..   |...|.:     :..||.||.||.|.:||.:.:....||....|.|.
  Fly   266 KYDVPSCLNYVRSALAVADCNFGGA-----EQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLR 325

Human   199 SGPDPAFPRDSQNPLLMWAAPDP-ATGQNGPR----------GLYAFGAERGNREPFLQALGLLW 252
            |.|...|    .|.||      | ||...||.          ..:|.|..|.|..||...:..::
  Fly   326 STPRGEF----DNALL------PIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIF 380

Human   253 FRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL-QKTLPEYTGYRPFLDP 316
            .|.||..|..|.:::|.|.||:|||.|:...:..|:.:.:.||||..| ||...|....:|....
  Fly   381 MRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQPNRAL 445

Human   317 SISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSV--SRALRVCNSYWSREH---PSLQ 376
            .:|:||..|:.:|..:|:|..:..........|....|..|  |:.|...|.:..:|.   |.||
  Fly   446 EVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQ 510

Human   377 -SAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLG-LPSYTKAR 439
             :::.::.:|..:.:|...:.|......|  .|....|.:..|.||..:|||||.| ||.|....
  Fly   511 YTSQKLNNILESLLNQETMKMDAAYSGGV--VWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLE 573

Human   440 AALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSW--LELLPGGLLES--HRDPGPLFSTI 500
            :.:...|:..|:|....:.   ..||:....:|   .||  ::|:.||:.|:  |...||.||.|
  Fly   574 SCVLSRPVESWKDFEHFIP---SDVLDKLKTIY---ASWADVDLIVGGISENPVHGSIGPTFSCI 632

Human   501 VLEQFVRLRDGDRYWFENTRNGLFSKKE-IEEIRNTTLQDVLVAVINIDPSALQPNVF 557
            :.||||.:..      :|.:..:....| :|:.|:  .....:..:|...||:..|:|
  Fly   633 ISEQFVHVLK------QNQQKAVQKHTELVEQYRH--FNGTKLLCLNSGLSAVPQNIF 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUOX1NP_059130.2 Peroxidase-like, mediates peroxidase activity 26..593 148/578 (26%)
dual_peroxidase_like 32..591 CDD:188652 148/578 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..172 5/24 (21%)
EFh 820..881 CDD:238008
EFh 857..915 CDD:238008
Interaction with TXNDC11. /evidence=ECO:0000250 956..1248
PLN02292 1089..>1412 CDD:215165
NOX_Duox_like_FAD_NADP 1277..1551 CDD:99783
IrcNP_650584.1 An_peroxidase 151..682 CDD:460804 147/576 (26%)
Blue background indicates that the domain is not in the aligned region.

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