DRSC/TRiP Functional Genomics Resources

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Protein Alignment DUOX1 and Pxn

DIOPT Version :10

Sequence 1:NP_059130.2 Gene:DUOX1 / 53905 HGNCID:3062 Length:1551 Species:Homo sapiens
Sequence 2:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster


Alignment Length:747 Identity:196/747 - (26%)
Similarity:314/747 - (42%) Gaps:158/747 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    33 DGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLG-------EPHL-PNPRDLSNTISRGPAGL 89
            ||..|||....||:..:..:||.|..|.:|...|:|       ..|. |:.|.:|.::.......
  Fly   781 DGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVSTSLVATKEIT 845

Human    90 ASLRNRTVL---GVFFGYHVLSDLVSVET---------------PGCPAEFLNIRIPPGDPMFDP 136
            ...|...::   |.|..:.:...:.||.:               |.|    ..|.:||.||....
  Fly   846 PDARITHMVMQWGQFLDHDLDHAIPSVSSESWDGIDCKKSCEMAPPC----YPIEVPPNDPRVRN 906

Human   137 DQRGDVVLPFQRSRWDPETGRS-----PSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFS--R 194
            .:..|||    ||.....:|.:     ....|:..||:|.::|.|.:||.|.:::..||:.:  .
  Fly   907 RRCIDVV----RSSAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQELRNLTSQE 967

Human   195 GQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGL-------YAFGAERGNREPFLQALGLLW 252
            |.|..|..  |||  |..:|.:|||.  .|.:..|.|       :..|..|.|.:..|.|:..:|
  Fly   968 GLLRVGVH--FPR--QKDMLPFAAPQ--DGMDCRRNLDENTMSCFVSGDIRVNEQVGLLAMHTIW 1026

Human   253 FRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL----QKTLPEYTGYRPF 313
            .|.||..|.:|.:.:..|:.:.|:|.|||.|.|..|:|...:|||..:    .:.:.||.||.|.
  Fly  1027 MREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEMMGEYQGYNPQ 1091

Human   314 LDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSA 378
            |:|||::||..|:.:|..|::.|.::..|.:  ||.:...:..:.:|.   .:.|     .|...
  Fly  1092 LNPSIANEFATAALRFGHTIINPILHRLNET--FQPIPQGHLLLHKAF---FAPW-----RLAYE 1146

Human   379 EDVDALLLGMASQIAERE--DHVLVEDVRDFWPGPLKFSRTDHLASC------LQRGRDLGLPSY 435
            ..||.|:.|..:..|:.:  |..|..::.:      |..:|.|..:.      :|||||.|:|.|
  Fly  1147 GGVDPLMRGFLAVPAKLKTPDQNLNTELTE------KLFQTAHAVALDLAAINIQRGRDHGMPGY 1205

Human   436 TKARAALGLSPITRWQDINPALSRSNDTVLEATAALY----NQDLSWLELLPGGLLESHRD---P 493
            ...|....|:....::|:...:|.:.  :.:....||    |.|: ||    ||:||...:   .
  Fly  1206 NVYRKLCNLTVAQDFEDLAGEISSAE--IRQKMKELYGHPDNVDV-WL----GGILEDQVEGGKV 1263

Human   494 GPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAV-INIDPSALQPNVF 557
            ||||..:::|||.|||||||.::||.  |:||.:::.:|:......||..| .|.|  .:..|||
  Fly  1264 GPLFQCLLVEQFRRLRDGDRLYYENP--GVFSPEQLTQIKQANFGRVLCDVGDNFD--QVTENVF 1324

Human   558 VW--HKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLC--CFPLVSLLSAWI--V 616
            :.  |:|            |...|...:          |..:.:...|  |....::..::|  .
  Fly  1325 ILAKHQG------------GYKKCEDII----------GINLYLWQECGRCNSPPAIFDSYIPQT 1367

Human   617 ARLRMRNFKRLQGQDRQSI---------------VSEKLVGGMEALEWQGHKEPCRPVLVYLQPG 666
            ...|....||..|::...:               |:|:.|.|:|.|.....||     |..|.. 
  Fly  1368 YTKRSNRQKRDLGKENDEVATAESYDSPLESLYDVNEERVSGLEELIGSFQKE-----LKKLHK- 1426

Human   667 QIRVVDGRLT------VLRTIQL--QPPQKVN 690
            ::|.::....      |.:.:||  .|||.|:
  Fly  1427 KLRKLEDSCNSADSEPVAQVVQLAAAPPQLVS 1458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUOX1NP_059130.2 Peroxidase-like, mediates peroxidase activity 26..593 170/621 (27%)
dual_peroxidase_like 32..591 CDD:188652 170/619 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..172 5/26 (19%)
EFh 820..881 CDD:238008
EFh 857..915 CDD:238008
Interaction with TXNDC11. /evidence=ECO:0000250 956..1248
PLN02292 1089..>1412 CDD:215165
NOX_Duox_like_FAD_NADP 1277..1551 CDD:99783
PxnNP_523891.2 leucine-rich repeat 54..77 CDD:275380
LRR <55..>184 CDD:443914
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380
leucine-rich repeat 126..149 CDD:275380
leucine-rich repeat 150..173 CDD:275380
Ig_3 235..311 CDD:464046
Ig 366..450 CDD:472250
Ig strand B 384..388 CDD:409544
Ig strand C 397..401 CDD:409544
Ig strand E 420..424 CDD:409544
Ig strand F 434..439 CDD:409544
Ig strand G 447..450 CDD:409544
Ig_3 458..533 CDD:464046
Ig 553..644 CDD:472250
Ig strand B 570..574 CDD:409353
Ig strand C 584..588 CDD:409353
Ig strand E 610..614 CDD:409353
Ig strand F 624..629 CDD:409353
Ig strand G 638..641 CDD:409353
peroxidasin_like 898..1338 CDD:188658 144/488 (30%)
VWC 1465..1523 CDD:278520
Blue background indicates that the domain is not in the aligned region.

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