Protein Alignment DUOX1 and CG10211

DIOPT Version :10

• Sequence 1: NP_059130.2
• Gene: DUOX1 / 53905
• HGNCID: 3062
• Length: 1551
• Species: Homo sapiens
• Sequence 2: NP_609883.1
• Gene: CG10211 / 35106
• FlyBaseID: FBgn0032685
• Length: 1394
• Species: Drosophila melanogaster
• Alignment Length: 721
• Identity: 191/721 - (26%)
• Similarity: 286/721 - (39%)
• Gaps: 150/721 - (20%)

Human    21 AQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQP----LGEPHLPNPRDLSNT 81
            |.:|.    :...|..|||....||...:...||:||.|.||:..|    :....|||||.:|.|
  Fly   715 ANSPF----RTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPRLTGVTGTALPNPRTISTT 775

Human    82 ISRGPAGLASLRNRTVLGVF-FGYHVLSDLVSV--------ETPGC-PAEFLNIRIPPGDPMFDP 136
            |.   ..:::|..|..|.|. |...|..||...        ..|.| |........|..:|.  |
  Fly   776 IH---PDISNLHTRYSLMVMQFAQFVDHDLTLTPIHKGFHESIPSCRPCNSRQTVHPECNPF--P 835

Human   137 DQRGDVVLP-----------FQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALR 190
            ...||...|           |...|..|  |:....|||..||.|.:||||.:||.:...|:.||
  Fly   836 VPAGDFYYPEVNVTSGERFCFPSMRSLP--GQQSLGPRDQINQNTHFLDGSMVYGETTCLSNKLR 898

Human   191 SFS--------RGQ--LASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFL 245
            .||        ||:  |..||.|..  .|:|.|                 .:..|.:|.:.:|.|
  Fly   899 GFSGRMNSTQVRGKELLPLGPHPEC--KSRNGL-----------------CFLGGDDRASEQPGL 944

Human   246 QALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQ--------- 301
            .|:...:.|.||...:.|...:|.|..|:||.||||.|.|..|:|...|:||..|.
  Fly   945 TAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIVFNEFLPRILSWNAVNLYGL 1009

Human   302 KTLPE--YTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVC 364
            |.||:  |..|.|...|.:.:||.||:.:...:::.|         |...:..::..|...|.:.
  Fly  1010 KLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRP---------HIPRLSVQHQPVEPPLLLR 1065

Human   365 NSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRD--FWPGPLKFSRTDHLASCLQRG 427
            :.::..:  :|.....:|.:|.|:.:...|..|..:..:|.:  |....:.||..|.:|..:||.
  Fly  1066 DGFFRMD--ALLQPGIIDEILRGLVATPMETLDQFITGEVTNHLFEDRKIPFSGIDLIALNIQRA 1128

Human   428 RDLGLPSYTKARAALGLSPITRWQDINPALSRSNDT-VLEATAALYNQDLSWLELLPGGLLESHR 491
            ||.|:|||...||...|...|.|.|    |||...| |:.....:| ..:..::|.||.:.|.
  Fly  1129 RDHGIPSYNNYRALCNLKRATNWND----LSREIPTEVINRFQKIY-ASVDDIDLFPGAMTER-- 1186

Human   492 DP------GPLFSTIVLEQFVRLRDGDRYWFENTRNGL-FSKKEIEEIRNTTLQ----------- 538
             |      ||..:.|:..||.:||..||:|:||....: |::.::.|:|..||.
  Fly  1187 -PLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLAKIVCENLEITG 1250

Human   539 DVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFG-FGVTIGTL 602
            |:..|..::..:.|.|.|       ||        ..:|....:..|:..:|...| ..|.:|..
  Fly  1251 DMQRAAFDLPSNFLNPRV-------PC--------ASMPQIDLNAWRENVQGCQIGNRNVRVGES 1300

Human   603 C----CFPLVSLLSAWIVARLRMRNFKRLQGQ-DRQSIVSEKL-------------VGGMEALEW 649
            .    |...|........|.||:.:..:|..| .:::|:.:::             ..|....:.
  Fly  1301 AFPSPCTSCVCSAEGAQCASLRITDCGQLIRQWPKEAILRDEVCNSQCGIYLTGQQASGFNPQQR 1365

Human   650 QGHKEP 655
            ||..:|
  Fly  1366 QGQAQP 1371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUOX1	NP_059130.2	Peroxidase-like, mediates peroxidase activity	26..593		174/633 (27%)
		dual_peroxidase_like	32..591	CDD:188652	173/625 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..172		9/21 (43%)
		EFh	820..881	CDD:238008
		EFh	857..915	CDD:238008
		Interaction with TXNDC11. /evidence=ECO:0000250	956..1248
		PLN02292	1089..>1412	CDD:215165
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783
CG10211	NP_609883.1	An_peroxidase	69..537	CDD:460804
		An_peroxidase	719..1257	CDD:460804	166/586 (28%)