Protein Alignment DUOX1 and Pxd

DIOPT Version :10

• Sequence 1: NP_059130.2
• Gene: DUOX1 / 53905
• HGNCID: 3062
• Length: 1551
• Species: Homo sapiens
• Sequence 2: NP_996223.1
• Gene: Pxd / 2768671
• FlyBaseID: FBgn0004577
• Length: 690
• Species: Drosophila melanogaster
• Alignment Length: 607
• Identity: 163/607 - (26%)
• Similarity: 253/607 - (41%)
• Gaps: 120/607 - (19%)

Human    33 DGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQP-------------------LGEPHLPNP--- 75
            ||..|:|.:...|...|:..||:...||||:..|                   .||..:|:|
  Fly   109 DGSCNHLEQPGLGVANSKYGRLLTPKYADGISAPTRSVTGDELPSARLVSLVAFGEQDVPDPEFT 173

Human    76 -------RDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSD---LVSVET--PGCPAEFLNIRIP 128
                   :.:::.:|....|..|.::.|        ...:|   |:.::|  ..|.|    |.:|
  Fly   174 LHNMQWGQIMTHDMSMQAGGTQSKKHPT--------RCCTDDGRLIGLDTAHKTCFA----IIVP 226

Human   129 PGDPMFDPDQRGDVVLPFQRSRWDPETG-RSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSF 192
            |.||.:  .|.|...|.|.|:..|.::. :....|.:....||.:||.|.:||:|...:..:|.|
  Fly   227 PHDPAY--SQVGTECLNFVRTLTDRDSNCQYQGGPAEQLTVVTSYLDLSLVYGNSIQQNSDIREF 289

Human   193 SRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQ----NGPRGLYAFGAERGNREPFLQALGLLWF 253
            ..|::..        :.:|...........||.    :.....|..|..|.|:.|.|..|..:..
  Fly   290 QGGRMIV--------EERNGAKWLPLSRNVTGDCDAVDASEVCYRSGDVRVNQNPGLAILQTILL 346

Human   254 RYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL--QKTLPEYTGYR----- 311
            |.||..|..|:..:|.::|..|||.|||..||.||.|:.|||||.||  :..|.....|:
  Fly   347 REHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLPIFLGGENMLKNRLIYKAPSGS 411

Human   312 ------PFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRAL-RVCNSYWS 369
                  |.:|||:.:|...|:.::..:.:             :|.::..|.:.:.| .:..|.|.
  Fly   412 YINDFDPNIDPSVLNEHATAAFRYFHSQI-------------EGRLDLLSELRQVLGSLTLSDWF 463

Human   370 REHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSR-----TDHLASCLQRGRD 429
            .....::..::.|:|..|.|:|..|..|......::.|     .|.|     :|..:..:||.||
  Fly   464 NRPGIIEVGDNFDSLTRGHATQPEELTDINFDRQIKHF-----LFRRNMPFGSDLRSLDIQRNRD 523

Human   430 LGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALY--NQDLSWLELLPGGLLESH-- 490
            .||.||...|...||.....|:.....:|   ..:||...:||  ::|   ::|..|..||:|
  Fly   524 HGLASYNDMREFCGLRRAHSWEGYGDLIS---PPILEKLKSLYPSHED---VDLTVGASLEAHVA 582

Human   491 -RDPGPLFSTIVLEQFVRLRDGDRYWFEN--TRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSAL 552
             ...||.|..|:.|||.|.|.|||::|||  ...| |:..::||:|..::..:|....| ..|::
  Fly   583 GALAGPTFLCILTEQFYRTRVGDRFFFENGDKLTG-FTPDQLEELRKASMARLLCDNGN-HISSM 645

Human   553 QPNVF--VWHKGD--PC---PQ 567
            ||..|  |.|...  ||   ||
  Fly   646 QPEAFRTVSHSNPIIPCSNIPQ 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUOX1	NP_059130.2	Peroxidase-like, mediates peroxidase activity	26..593		163/607 (27%)
		dual_peroxidase_like	32..591	CDD:188652	163/607 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..172		4/22 (18%)
		EFh	820..881	CDD:238008
		EFh	857..915	CDD:238008
		Interaction with TXNDC11. /evidence=ECO:0000250	956..1248
		PLN02292	1089..>1412	CDD:215165
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783
Pxd	NP_996223.1	An_peroxidase	105..650	CDD:460804	156/588 (27%)