Protein Alignment MYO3A and MYO1

DIOPT Version :10

• Sequence 1: NP_059129.3
• Gene: MYO3A / 53904
• HGNCID: 7601
• Length: 1616
• Species: Homo sapiens
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1605
• Identity: 413/1605 - (25%)
• Similarity: 688/1605 - (42%)
• Gaps: 370/1605 - (23%)

Human   279 SELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGTEKARRERIHTKKGNFNRPLISNLKDVDDL 343
            :::.::||..|            .|.|||...:..||.:...::.........|  |....|:::
Yeast    30 TDINKNKFTGQ------------EEQIGIVHPLDSTEVSNLVQVRISDVFPVNP--STFDKVENM 80

Human   344 ATLEILDENTVSEQLEKCYSRDQIYVYVGDILIALNPFQSLGLYSTKHSKLYIGSKRTAS----- 403
            :.|..|:|.:|...|||.|..|.||.|.|..|:|:||:.:|.|||..|..||.......|
Yeast    81 SELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLD 145

Human   404 -------PPHIFAMADLGYQSMITYNSDQCIVISGESGAGKTENAHLLVQQLT------------ 449
                   ||||||:|:..|:::::...||.|:::||||||||||...::|.|.
Yeast   146 ENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNIAP 210

Human   450 VLGKANNRTLQEKILQVNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKS 514
            |.|.:...:.:.||||.|.::|:||||.|:.|:|||||||:::::|...|.:.||.|..||||||
Yeast   211 VSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKS 275

Human   515 RVIHQAIGEKNFHIFYYIYAGL--AEKKKL-------AHYKLPENKPPRYLQNDHLRTVQDIMNN 570
            |::||...|:|:||||.:.:||  :|.|.|       ..||:..|.     ..|.:..:.|:.|
Yeast   276 RIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNS-----NQDIIPGINDVEN- 334

Human   571 SFYKSQYELIEQCFKVIGFTMEQLGSIYSILAAILNVGNIEFSSVATEHQIDKSHISNHTALENC 635
                  ::.:.....:|||:.:|:..|:.::|.||.:|||||.|...|          ..:.:|.
Yeast   335 ------FKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDRAE----------QASFKND 383

Human   636 ASLLC--IRADE--LQEALTSHCVVTRGETIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCINS 696
            .|.:|  :..||  .|.|:.........|.:.:....::|..:.:|:::.||.|||.:||:.||.
Yeast   384 VSAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINK 448

Human   697 LLKHDSSPSGNGDELSIGILDIFGFENFKKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYLNED 761
            .|.|.|:...     .||:|||.|||.|:.|||||||||..||::|.::|.|:|..||:|||.|:
Yeast   449 NLDHGSATLN-----YIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKEN 508

Human   762 VDARVIEYEDNWPL-LDMFLQK--PMGLLSLLDEESRFPKATDQT----LVEKFEGNLKSQYFWR 819
            :....|:|..:..| :|:...|  |.|:|.|||||:..||:||::    |:..::.|  |..|.|
Yeast   509 IQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQN--SSKFKR 571

Human   820 PKRMELSFGIHHYAGKVLYNASGFLAKNRDTLPTDIVLLLRSSDNSVIRQLVNHPLTKTGNLPHS 884
             .|::..|.:.||||.|.|...|:|:||:|.|..:::.||.||.|.:|.:|..         |..
Yeast   572 -SRLKNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQ---------PEG 626

Human   885 KTKNVINYQMRTSEKLINLAKGDTGEATRHARETTNMKTQTVASYFRYSLMDLLSKMVVGQPHFV 949
            :..:....:...|.:          |..:.||.:|   .:|.:|..|...:.||:::....||||
Yeast   627 EKSSSAGVEANISNQ----------EVKKSARTST---FKTTSSRHREQQITLLNQLASTHPHFV 678

Human   950 RCIKPNSERQARKYDKEKVLLQLRYTGILETARIRRLGFSHRILFANFIKRYYLLCYKSSEEPRM 1014
            |||.||:.::.:.:::..:|.|||..|:||..|:.|.|:.:||.|..|.:||.:|..::|.....
Yeast   679 RCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTF 743

Human  1015 S-------PDTCATILEKAGLDN--WALGKTKVFLKYYHVEQLNLMRKEAIDKLIL-IQACVRAF 1069
            |       ...|..:|....||.  :.:|.||:|.|...:..|...:...::.::: :.|.:|.:
Yeast   744 SSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGY 808

Human  1070 LCSRRYQKIQEKRKESAIIIQSAARGHLVRKQRKEIV-------------------DMK-----N 1110
            ...:......:|.|::.:|      |:..|...:.:.                   ||.     |
Yeast   809 TVRKEITYHLQKLKKTRVI------GNTFRLYNRLVKEDPWFNLFIRIKPLLTSSNDMTRTKKFN 867

Human  1111 TAVTTIQTSDQEFDYKKNF------------ENTR-------------ESFVKKQAENAISANER 1150
            ..:..::...||.:.||.|            |||:             ||.:.:...::.:..::
Yeast   868 EQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQ 932

Human  1151 FISAPNNKGSVSVVKTSTFKPEEETTNAVESNNRVYQ----TPKKMNNVYEEEVKQEFYLVGPEV 1211
            |....:.|..:|..|....:..||....::......:    |.:|:::...|.:||...| ..::
Yeast   933 FDDLVSEKDEISREKLEVAQNLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQISDL-NCDI 996

Human  1212 SPKQKSVKDLEENSNLRKVEKE-----------EAMIQSYYQRYTEERNCEESKAAYLERK---A 1262
            | |::|.:.|.:.|.| |:|.|           |..|:|:..:.:......:.|...||:.   |
Yeast   997 S-KEQSSQSLIKESKL-KLENEIKRLKDVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNCNIA 1059

Human  1263 ISERPSYPVPWLAEN------ETSFKKTLEPTLSQRSIYQNANSMEKEK----KTSVVT---QRA 1314
            :|...|.    :.||      ..:|||......:|....::.....|||    |..:.|   ||.
Yeast  1060 MSRLQSL----VTENSDLRSKNENFKKEKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRD 1120

Human  1315 PICSQEEGRGRLRHETVKERQVEPVTQAQEEEDKAAVFIQSKYRGYKRRQQLRKDK--------- 1370
            ...|:   .|::..| :||.::: :|:.:....|    |:.:|..::|..:.::.|
Yeast  1121 DAVSE---HGKITAE-LKETRIQ-LTEYKSNYQK----IKEEYSNFQRETKEQEQKKRNSLVESL 1176

Human  1371 -----------------MSSFKHQRI----VTTPTEVARNTHNLYSYPTKHEEI----------- 1403
                             ::.:.::||    |.|.....|.:.:....|...|:|
Yeast  1177 NDSKIKELEARLSQEISLNQYLNKRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDLQLAF 1241

Human  1404 --------NNIKKKDNKDSK--------ATSEREACGLAIFSKQISKLSEEY-------FILQKK 1445
                    |.|::|.|..|:        |:|..|...:....|::.||.::.       .||.:.
Yeast  1242 TEITRNLENEIEEKKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEP 1306

Human  1446 L----------NEMILSQQLKSLYLGV---SHHKPIN---------RRVSSQQCLSGV------- 1481
            |          |:::|........|.:   :|:...|         |::..:..||..
Yeast  1307 LDNCPDKESDINKLMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKF 1371

Human  1482 ------CKGEEPKILRPPRRPRKPKTLNNP---------------EDSTYYYLLHKSIQEEKRRP 1525
                  .|..|.|:...|.|.|    .|.|               |:..||.|.:..:||    .
Yeast  1372 EASEERVKSLEDKLKTMPLRDR----TNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQE----I 1428

Human  1526 RKDSQGKL----LDLEDFYYKEF------------LPSRSGPKEHSPSLRERRPQQ------ELQ 1568
            ..:|.|||    |||.....||.            |.|....||...|..:::.||      :||
Yeast  1429 LNESNGKLSQLTLDLRQSKSKEALLSEQLDRLQKDLESTERQKELLSSTIKQQKQQFENCMDDLQ 1493

Human  1569 NQCIKANERCWAAESPEKEEEREPAANPYDFRRLLRKTSQRRRLV 1613
            ...::..|...|.:..|::.:...:.    ..:|..:..|:.:|:
Yeast  1494 GNELRLREHIHALKQAEEDVKNMASI----IEKLKTQNKQKEKLI 1534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO3A	NP_059129.3	STKc_myosinIIIA_N	2..287	CDD:132969	1/7 (14%)
		MYSc_Myo3	352..1041	CDD:276830	254/741 (34%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	934..956		10/21 (48%)
		Interaction with MORN4. /evidence=ECO:0000269|PubMed:25822849	1401..1479		22/133 (17%)
		MBD_Myo3a	1409..1456	CDD:439318	14/71 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1567		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1581..1616		4/33 (12%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	413/1605 (26%)
		Smc	1607..>1901	CDD:440809