Protein Alignment GPR84 and AstA-R2

DIOPT Version :10

• Sequence 1: NP_065103.1
• Gene: GPR84 / 53831
• HGNCID: 4535
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Alignment Length: 380
• Identity: 82/380 - (21%)
• Similarity: 141/380 - (37%)
• Gaps: 129/380 - (33%)

Human    29 VVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFC 93
            |:|:||..||:|.:|.:.....:|:..||:|.||..|||::..|..||:...|:..:|..|..:|
  Fly    47 VIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWC 111

Human    94 RVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVL-ALVSTWVVGVASFAPLWP 157
            |....|:..:...||.||.|:::.|:|.:.|| :..::...:.|.| |:|:.|:|         .
  Fly   112 RSVQYLIVVTAFASIYTLVLMSIDRFLAVVHP-IRSRMMRTENITLIAIVTLWIV---------V 166

Human   158 IYILVPVVCT-----------------CSF---DRIRGRPYTTILMGIYFVLGLSSVGIFYCLIH 202
            :.:.|||..|                 |:|   |.:..|.|........::|.|..:.
  Fly   167 LVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIIS------- 224

Human   203 RQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTL 267
                                             |.:..:..||...|....:|.|
  Fly   225 ---------------------------------GLYMRMIMRLWRQGTGVRMSKE---------- 246

Human   268 EGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSY 332
                        |:|.::                              :|||:...|.:.||..:
  Fly   247 ------------SQRGRK------------------------------RVTRLVVVVVIAFASLW 269

Human   333 IPFLL------LNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAY 381
            :|..|      |::::.......|:.:.|..|.:.:.||||:|||.::..||:|:
  Fly   270 LPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAF 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR84	NP_065103.1	7tmA_GPR84-like	21..381	CDD:320338	81/378 (21%)
		TM helix 1	22..48	CDD:320338	8/18 (44%)
		TM helix 2	55..78	CDD:320338	11/22 (50%)
		TM helix 3	93..123	CDD:320338	10/29 (34%)
		TM helix 4	137..155	CDD:320338	6/18 (33%)
		TM helix 5	175..200	CDD:320338	4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..311		7/66 (11%)
		TM helix 6	312..342	CDD:320338	9/35 (26%)
		TM helix 7	349..374	CDD:320338	10/24 (42%)
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	81/378 (21%)
		TM helix 1	40..66	CDD:320224	8/18 (44%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	10/29 (34%)
		TM helix 4	153..173	CDD:320224	7/28 (25%)
		TM helix 5	204..233	CDD:320224	5/68 (7%)
		TM helix 6	249..279	CDD:320224	9/59 (15%)
		TM helix 7	292..317	CDD:320224	10/24 (42%)