Protein Alignment GPR84 and Octbeta1R

DIOPT Version :10

• Sequence 1: NP_065103.1
• Gene: GPR84 / 53831
• HGNCID: 4535
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Alignment Length: 402
• Identity: 77/402 - (19%)
• Similarity: 156/402 - (38%)
• Gaps: 93/402 - (23%)

Human     3 NSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADL 67
            ::.||:.|. |.:::..:...:.:.::.|:   :||:|.::::....|||...|..:.:|.:||:
  Fly    94 STDDADGSS-HLALVFVKCFIIGFIILAAI---LGNMLVIVSVMRHRKLRIITNYFVVSLAVADM 154

Human    68 LYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVF 132
            |.......|:....:...|..|:..|.::.......::.||:.||.|::.||..|..|..:|.:.
  Fly   155 LVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIM 219

Human   133 SAKGIVLALVSTWV-VGVASFAPL---WPIYILVPVVCTCSFDRIRGRP----------YTTILM 183
            :.:.:.:.|:..|: ..:.||.|:   |       ...|.::..::..|          |..:..
  Fly   220 TQRRVFIMLLMVWLSPALLSFLPICSGW-------YTTTENYKYLKSNPHICEFKVNKAYAIVSS 277

Human   184 GI-YFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLAS 247
            .: :::.|:..:.::| .|:::..|..:.:  |:.:.|::                 .|:..|.
  Fly   278 SMSFWIPGIVMLSMYY-RIYQEADRQERLV--YRSKVAAL-----------------LLEKHLQ- 321

Human   248 GGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSS 312
                  ||..|                              |..|....:...|...||.
  Fly   322 ------ISQIP------------------------------KPRPSIQVEQSTISTMRRE----- 345

Human   313 EFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWL---NGCINPVLYAAMN 374
              .|..|....:...|.:.::||.|..|:.:...:.....:|...|.|:   |..:||::||..|
  Fly   346 --RKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFN 408

Human   375 RQFRQAYGSILK 386
            |.||.|:...||
  Fly   409 RDFRAAFKKTLK 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR84	NP_065103.1	7tmA_GPR84-like	21..381	CDD:320338	70/377 (19%)
		TM helix 1	22..48	CDD:320338	4/25 (16%)
		TM helix 2	55..78	CDD:320338	6/22 (27%)
		TM helix 3	93..123	CDD:320338	8/29 (28%)
		TM helix 4	137..155	CDD:320338	4/18 (22%)
		TM helix 5	175..200	CDD:320338	4/35 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..311		9/66 (14%)
		TM helix 6	312..342	CDD:320338	7/29 (24%)
		TM helix 7	349..374	CDD:320338	8/27 (30%)
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	70/379 (18%)
		TM helix 1	109..135	CDD:320194	4/28 (14%)
		TM helix 2	142..168	CDD:320194	6/25 (24%)
		TM helix 3	180..210	CDD:320194	8/29 (28%)
		TM helix 4	222..245	CDD:320194	5/22 (23%)
		TM helix 5	269..298	CDD:320194	4/29 (14%)
		TM helix 6	343..373	CDD:320194	9/36 (25%)
		TM helix 7	383..408	CDD:320194	8/24 (33%)