Protein Alignment GPR84 and CG4313

DIOPT Version :10

• Sequence 1: NP_065103.1
• Gene: GPR84 / 53831
• HGNCID: 4535
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_569971.3
• Gene: CG4313 / 31169
• FlyBaseID: FBgn0025632
• Length: 541
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 103/456 - (22%)
• Similarity: 186/456 - (40%)
• Gaps: 92/456 - (20%)

Human     9 FSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLL 73
            |..|.:.:|...:||.   :|..:.|..||:||::||:...:.|....:.|.||:.:|||:....
  Fly    69 FEGYSDELLTIAWVAC---IVFIIVGVPGNLLTIVALSRGRQTRNSTAIFIINLSCSDLLFGCFN 130

Human    74 QPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIV 138
            .|.:..|:....|......||:|.:|.:...:||:|::.||.:.||::||||:.:|:::..:.:.
  Fly   131 LPLAASTFKERAWTHSDLLCRLFPMLRYGLLAVSLLSVSLITINRYIIIAHPRQYPRIYQRRYLA 195

Human   139 LALVSTWVVGVASFAP----LWPIYILVPVVCTCSF--DRIRGRPYTTILMGIYFVLGLSSVGIF 197
            |.:..||:...:...|    :|.|:.|...:.:||.  ||. ||.....|....|::....:.|.
  Fly   196 LMVAGTWITTFSIMIPTWRGVWGIFGLDVSIGSCSIMHDRY-GRSPKEFLFIAAFMVPCICIVIC 259

Human   198 YCLIHRQVKRAA------------------------QALDQYKLRQASIHSNHVARTDEAMPGRF 238
            |..|...|::||                        ||:...|..:....|:  ...:|.:.||.
  Fly   260 YARIFLLVRKAAIRAGTAGKTNVSDVTPSSAPQHQIQAMATPKKPEKVTTSS--GEANEPIAGRP 322

Human   239 QELDSRLASGGPSEGISSEPVS--------------------------------------AATTQ 265
            ..::..||....:....|.|:|                                      .:.||
  Fly   323 FVVEENLAYIDDNASTDSLPISYSIRRRDQDQQPPPVDANVVLKEREKERDRDQEKVSLGRSQTQ 387

Human   266 TLEGDSSEVGDQINSKRAKQMAEKSPPEA-------SAKAQPIKGARRAPDSSSEFGKVTRMCFA 323
            ...|.:........|.|.......||.::       ::.|..|...|    .|::..::.:|...
  Fly   388 LEMGKTHGKNPITTSLRTTSFTRFSPRKSHYASMGNTSNASSIYPGR----MSAKDRRLLKMILV 448

Human   324 VFLCFALSYIPFLLLNILDARVQAPRVVH---MLAANLTWLNGCINPVLYAAMNRQFRQAYGSIL 385
            :|:.|.:.|:|..:..|..:..:    ||   :....|.:|..||||::|..|:.::|:||.::|
  Fly   449 IFVWFVICYLPITVAKIWKSATE----VHWFNIAGYLLIYLTTCINPLIYVLMSSEYRRAYWNLL 509

Human   386 K 386
            :
  Fly   510 R 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR84	NP_065103.1	7tmA_GPR84-like	21..381	CDD:320338	97/437 (22%)
		TM helix 1	22..48	CDD:320338	10/25 (40%)
		TM helix 2	55..78	CDD:320338	7/22 (32%)
		TM helix 3	93..123	CDD:320338	11/29 (38%)
		TM helix 4	137..155	CDD:320338	4/21 (19%)
		TM helix 5	175..200	CDD:320338	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..311		15/111 (14%)
		TM helix 6	312..342	CDD:320338	6/29 (21%)
		TM helix 7	349..374	CDD:320338	9/27 (33%)
CG4313	NP_569971.3	7tmA_GPR84-like	78..505	CDD:320338	97/440 (22%)
		TM helix 1	79..105	CDD:320338	10/28 (36%)
		TM helix 2	112..135	CDD:320338	7/22 (32%)
		TM helix 3	150..180	CDD:320338	11/29 (38%)
		TM helix 4	194..212	CDD:320338	3/17 (18%)
		TM helix 5	237..262	CDD:320338	6/24 (25%)
		TM helix 6	437..467	CDD:320338	6/29 (21%)
		TM helix 7	473..498	CDD:320338	8/24 (33%)