Protein Alignment GPR84 and Tre1

DIOPT Version :10

• Sequence 1: NP_065103.1
• Gene: GPR84 / 53831
• HGNCID: 4535
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_001284901.1
• Gene: Tre1 / 140439
• FlyBaseID: FBgn0046687
• Length: 399
• Species: Drosophila melanogaster
• Alignment Length: 416
• Identity: 107/416 - (25%)
• Similarity: 173/416 - (41%)
• Gaps: 103/416 - (24%)

Human     7 ANFSCY-HESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLR----TRFNLLIANLTLAD 66
            |..|.| |.:.|   :.|:|..|.|.: |.:||::|||||...|.:|    |.|   :.:|:::|
  Fly    25 ATQSIYPHSATL---FAAISACVFVTI-GVLGNLITLLALLKSPTIREHATTAF---VISLSISD 82

Human    67 LLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQV 131
            ||:|:...|.:...:....|..|.|.|::|.::.:.:.:||:|::..|.|.||:|||....:.|:
  Fly    83 LLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQI 147

Human   132 FSAKGIVLALVSTWVVGVASFAP----LWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLS 192
            :..|.|.|.|:..|.|......|    :|....|.....:|:..:..||.....|..|.|:|...
  Fly   148 YKPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRSIKKTLFVIGFLLPCL 212

Human   193 SVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSE 257
            .:.:.|..|:..|           |.|.....||         ..||
  Fly   213 VIIVSYSCIYITV-----------LHQKKKIRNH---------DNFQ------------------ 239

Human   258 PVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCF 322
             ::||     :|.||..|....:....:.|.                        |..::|.|..
  Fly   240 -IAAA-----KGSSSSGGGSYMTTTCTRKAR------------------------EDNRLTVMMV 274

Human   323 AVFLCFALSYIPFLLLNIL-DARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQ-------FRQ 379
            .:||||.:.::|.:|.|:: |.|..:...:|::|:.:.|.:..|||::|||.||.       ||.
  Fly   275 TIFLCFLVCFLPLMLANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNYSESIFYFRV 339

Human   380 AY----------GSILKRGP-RSFHR 394
            ||          |..|...| |::|:
  Fly   340 AYYKIFALLKFWGEPLSPMPSRNYHQ 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPR84	NP_065103.1	7tmA_GPR84-like	21..381	CDD:320338	95/375 (25%)
		TM helix 1	22..48	CDD:320338	12/25 (48%)
		TM helix 2	55..78	CDD:320338	7/22 (32%)
		TM helix 3	93..123	CDD:320338	10/29 (34%)
		TM helix 4	137..155	CDD:320338	6/21 (29%)
		TM helix 5	175..200	CDD:320338	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..311		7/66 (11%)
		TM helix 6	312..342	CDD:320338	10/30 (33%)
		TM helix 7	349..374	CDD:320338	9/24 (38%)
Tre1	NP_001284901.1	7tmA_GPR84-like	37..341	CDD:320338	95/375 (25%)
		TM helix 1	37..63	CDD:320338	12/26 (46%)
		TM helix 2	71..94	CDD:320338	8/25 (32%)
		TM helix 3	109..139	CDD:320338	10/29 (34%)
		TM helix 4	153..171	CDD:320338	5/17 (29%)
		TM helix 5	195..220	CDD:320338	7/24 (29%)
		TM helix 6	264..294	CDD:320338	10/53 (19%)
		TM helix 7	302..327	CDD:320338	9/24 (38%)