Protein Alignment ATP7A and CCC2

DIOPT Version :10

• Sequence 1: NP_000043.4
• Gene: ATP7A / 538
• HGNCID: 869
• Length: 1500
• Species: Homo sapiens
• Sequence 2: NP_010556.1
• Gene: CCC2 / 851862
• SGDID: S000002678
• Length: 1004
• Species: Saccharomyces cerevisiae
• Alignment Length: 1103
• Identity: 360/1103 - (32%)
• Similarity: 570/1103 - (51%)
• Gaps: 183/1103 - (16%)

Human   377 QETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFD 441
            :|.::.:.||||::|..:|...:....||....:||..:...|.||..:|: ::::..|||.|||
Yeast     2 REVILAVHGMTCSACTNTINTQLRALKGVTKCDISLVTNECQVTYDNEVTA-DSIKEIIEDCGFD 65

Human   442 ATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANI 506
            ..:...:|                         :|.:..||.       .:.|.||||.|||:.:
Yeast    66 CEILRDSE-------------------------ITAISTKEG-------LLSVQGMTCGSCVSTV 98

Human   507 ERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVR 571
            .:.:...||:.|::|:|:..:..|.|.|:........|.|.:.||.:.:|.   :|:|..:
Yeast    99 TKQVEGIEGVESVVVSLVTEECHVIYEPSKTTLETAREMIEDCGFDSNIIM---DGNGNAD---- 156

Human   572 GMTCASCVHKIESSLTKHRGILYCSVA--------------LATNKAH---IKYDPEIIGPRDII 619
             ||..:.:.|:..:......::..||:              ..::..|   |||....:|.||::
Yeast   157 -MTEKTVILKVTKAFEDESPLILSSVSERFQFLLDLGVKSIEISDDMHTLTIKYCCNELGIRDLL 220

Human   620 HTIESLGFEASLVKKDRSASHLDH---------KREIRQWRRSFLVSLFFCIPVMGLMIYMMVMD 675
            ..:|..|::.::.      |:||:         :.|||.|:::.:.|....|..|  ::||:|
Yeast   221 RHLERTGYKFTVF------SNLDNTTQLRLLSKEDEIRFWKKNSIKSTLLAIICM--LLYMIV-- 275

Human   676 HHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALK 740
                      .|....::......:.|...:.||...::|..:|...:||..|:|||..|:.:||
Yeast   276 ----------PMMWPTIVQDRIFPYKETSFVRGLFYRDILGVILASYIQFSVGFYFYKAAWASLK 330

Human   741 HKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVN--PITFFDTPPMLFVFIALGRWLEHIAKG 803
            |.:..||.|:.::||.|:.:|:..|:..|:..:...  |...|||..|:..:|::|::||.:||.
Yeast   331 HGSGTMDTLVCVSTTCAYTFSVFSLVHNMFHPSSTGKLPRIVFDTSIMIISYISIGKYLETLAKS 395

Human   804 KTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM 868
            :||.||:|||.|..:..:|:   ||......:::.:||:|..||:::.||.|.|.||.:..|.|.
Yeast   396 QTSTALSKLIQLTPSVCSII---SDVERNETKEIPIELLQVNDIVEIKPGMKIPADGIITRGESE 457

Human   869 VDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQF 933
            :||||:|||::.|.||.|..|||||:|..|......|.||.:|.|:.|:|:::|||.||||||.:
Yeast   458 IDESLMTGESILVPKKTGFPVIAGSVNGPGHFYFRTTTVGEETKLANIIKVMKEAQLSKAPIQGY 522

Human   934 ADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETI----IRFAFQASIT 994
            ||.|:..|||.|:.:::.|..:|..|  ||...        |..::.|...    .....|.:.:
Yeast   523 ADYLASIFVPGILILAVLTFFIWCFI--LNISA--------NPPVAFTANTKADNFFICLQTATS 577

Human   995 VLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQV 1059
            |:.:||||:||||||||:|||||||||||:||||||.||..:.:...|||||||:|.|..||.
Yeast   578 VVIVACPCALGLATPTAIMVGTGVGAQNGVLIKGGEVLEKFNSITTFVFDKTGTLTTGFMVVK-- 640

Human  1060 KVLTESN---RISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISC 1121
            |.|.:||   .:...::||.:...||.|:||:..||.:||.                    |::|
Yeast   641 KFLKDSNWVGNVDEDEVLACIKATESISDHPVSKAIIRYCD--------------------GLNC 685

Human  1122 KVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNRE 1186
                              |...||.:::     .:......::...|:    |...|.:.|||..
Yeast   686 ------------------NKALNAVVLE-----SEYVLGKGIVSKCQV----NGNTYDICIGNEA 723

Human  1187 WMIRNGL----VINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMG 1247
            .::.:.|    .||::|:        :|.|...|:|:..:.||..|.|.||.::...:..|:..|
Yeast   724 LILEDALKKSGFINSNVD--------QGNTVSYVSVNGHVFGLFEINDEVKHDSYATVQYLQRNG 780

Human  1248 LEVVLMTGDNSKTARSIASQVGIT--KVFAEVLPSHKVAKVKQLQE-EG-KRVAMVGDGINDSPA 1308
            .|..::||||:..|:.:|.:|||:  .|:::|.|:.|...||::|: || .:||:|||||||:||
Yeast   781 YETYMITGDNNSAAKRVAREVGISFENVYSDVSPTGKCDLVKKIQDKEGNNKVAVVGDGINDAPA 845

Human  1309 LAMANVGIAIGTGTDVAIEAADVVLI------RNDLLDVVASIDLSRKTVKRIRINFVFALIYNL 1367
            ||::::||||.|||::||||||:|::      .|.|..:..:||:|.||.|||::|..:||.||:
Yeast   846 LALSDLGIAISTGTEIAIEAADIVILCGNDLNTNSLRGLANAIDISLKTFKRIKLNLFWALCYNI 910

Human  1368 VGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESY---ELPARSQIG 1427
            ..||||.||.:|.|:.|.|.:...|||.||||||||||.||.:..|..||:   :..::..||
Yeast   911 FMIPIAMGVLIPWGITLPPMLAGLAMAFSSVSVVLSSLMLKKWTPPDIESHGISDFKSKFSIG 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7A	NP_000043.4	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219
		HMA	380..443	CDD:238219	20/62 (32%)
		HMA	492..554	CDD:238219	20/61 (33%)
		HMA	567..630	CDD:238219	14/79 (18%)
		P-type_ATPase_Cu-like	652..1388	CDD:319783	271/758 (36%)
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:Q64430	1467..1468
		PDZD11-binding	1486..1500
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:Q64430	1487..1488
CCC2	NP_010556.1	HMA	6..67	CDD:238219	20/61 (33%)
		HMA	84..144	CDD:238219	19/59 (32%)
		P-type_ATPase_Cu-like	259..938	CDD:319783	273/762 (36%)