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Protein Alignment ATP7A and atp7a

DIOPT Version :10

Sequence 1:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens
Sequence 2:	NP_001036185.1	Gene:	atp7a / 564924	ZFINID:	ZDB-GENE-060825-45	Length:	1482	Species:	Danio rerio

Alignment Length:	1510	Identity:	991/1510 - (65%)
Similarity:	1175/1510 - (77%)	Gaps:	61/1510 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    10 VTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAV 74
            ||:.||||||.|||.:||.:||.:.||.||:||||:.|||:.||....||:::.:||:||||::.
Zfish    10 VTLGVEGMTCGSCVQSIEGRIGGLPGVIHIQVSLEQNNATVTYDHTQHTPQSIADAIEDMGFESS 74

Human    75 IHNPDPLPVLTDT-LFLTVTASLTLPWDHIQ---STLLKTKGVTDIKIYPQKRTVAVTIIPSIVN 135
            :.|....||.|:| :|.....|.    |.:|   |||.:.|||.:.:.....:.:|||.:||:|:
Zfish    75 LTNATSTPVQTETKVFSKAGCSA----DSVQQALSTLAQIKGVIETQESADNQGLAVTFVPSLVS 135

Human   136 ANQIKELVPELSLDTG---TLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQ 197
            .:|:.|::..|:.||.   .|..|.|:.   |.:.:|...:||::|||.|.|||:|||||||||:
Zfish   136 EDQLGEVLKCLAPDTACRPPLSPKEGST---SRSFSGVEAVKMRIEGMVCLSCTTTIEGKIGKLK 197

Human   198 GVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKS 262
            ||::|||||::|||.:||.|::|:|:|:.||||..||.|.||.:|:.|||.|.:||||.:.| |.
Zfish   198 GVEKIKVSLESQEAAVVYLPYIITVDEIVKQIEVAGFKATVKSKPRQLKLSASEVERLLSAP-KQ 261

Human   263 SEGSQQRSPSYTNDSTAT--FIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASS 325
            :|......|:   |||.|  |.:.||||.|||.||:..:|.|..|:|:|||||||.|.:::|...
Zfish   262 TEEKLSEPPA---DSTVTTLFQVTGMHCNSCVVNIQDNISKLPAVTSVVVSLENRQASIQHNPKQ 323

Human   326 VTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNS 390
            |:...|:|||||:.||.::..|.:       ||....|         |||.....|:|:||||.|
Zfish   324 VSVVELQKAIEALPPGNFKAIIPA-------SPEPGFL---------QPLVSVAEIHIEGMTCGS 372

Human   391 CVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLV--V 453
            |||||||.:|:|.||:|.:|||||..||.||||||||||.||.|||||||||.|.:||. ||  |
Zfish   373 CVQSIEGTLSQKKGVRSAQVSLANHQGTFEYDPLLTSPEELRAAIEDMGFDAFLPETNS-LVPSV 436

Human   454 IAQPSSEMPLLTSTNEFYTKGMTPVQ----------DKEEGKNS-SKCYIQVTGMTCASCVANIE 507
            :..||   |.:.|::      ::||:          |.|...|: |||:||:.||||||||||||
Zfish   437 VKSPS---PSVRSSS------LSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIE 492

Human   508 RNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRG 572
            |||:.|.||:|:||||||.||||||:|:||.|..|||.||||||.|||::|.|..||.|||||||
Zfish   493 RNLKNEYGIHSVLVALMASKAEVRYSPSVIDPLRIAELIRELGFTATVMDNYDGSDGSLELVVRG 557

Human   573 MTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRS 637
            ||||||||||||:|.|.:||||.||||:|||||||||||:.||||||..||::||.||||||||.
Zfish   558 MTCASCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTASLVKKDRP 622

Human   638 ASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLE 702
            .|||||.||||||:|||.:|||||:||||:||||:|:||.....|.:.|.:.|:....||:||||
Zfish   623 GSHLDHSREIRQWKRSFQISLFFCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKYHSTMFLE 687

Human   703 RQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLV 767
            :|:|||||:|||:|||.||||||.||.|||.|||||:||:||||||||||||||||.||:::|||
Zfish   688 KQLLPGLSIMNLISFLFCVPVQFIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTYSVVVLLV 752

Human   768 AMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILL 832
            ||.|||||||||||||||||||||:||||||.|||.||||||:||:||||||||:|||:.|..:|
Zfish   753 AMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTLNEDMSVL 817

Human   833 SEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQN 897
            ||||||||||||||::||||||||||||||||||||.||||||||||||.|||||||||||||||
Zfish   818 SEEQVDVELVQRGDVVKVVPGGKFPVDGRVIEGHSMADESLITGEAMPVTKKPGSTVIAGSINQN 882

Human   898 GSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFL 962
            |||||.|||||.|||||||||||||||||||||||||||:|.|||||||.:|:.|||.||:|||:
Zfish   883 GSLLIKATHVGTDTTLSQIVKLVEEAQTSKAPIQQFADKISSYFVPFIVVISVLTLLAWIIIGFV 947

Human   963 NFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIK 1027
            ||.:|:||||||::|||..|.:|||||||||||||||||||||||||||||||||||||||||||
Zfish   948 NFSLVQTYFPGYDKSISEAEAVIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIK 1012

Human  1028 GGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAI 1092
            ||||||||||::.||||||||||:|.|.|.|||:|.|.||:...|:||||||||::||||||.||
Zfish  1013 GGEPLEMAHKIQSVVFDKTGTITYGAPKVVQVKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAI 1077

Human  1093 TKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQS 1157
            ||||||||.||:||||.|||.||||||.|.|:|.|.||.:.:.:.|:|. .||.|:||..:...
Zfish  1078 TKYCKQELGTESLGTCTDFQAVPGCGIRCLVSNTENLLKREDSDSEENQ-HNAVLIQISDARAH- 1140

Human  1158 STSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDEL 1222
            ||...:|:|.|....:....|.|||||||||.||.|.:..||::.||||||:|.||||||||:||
Zfish  1141 STEHPLIMDPQPLTVVQTASYTVLIGNREWMRRNALQVRADVDEAMTEHERRGCTAVLVAVDNEL 1205

Human  1223 CGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVK 1287
            |.::|||||||||||||:|:|.:|||||||||||||||||:||:||||.|||||||||||||||:
Zfish  1206 CAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAIAAQVGIRKVFAEVLPSHKVAKVE 1270

Human  1288 QLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTV 1352
            |||:.||||||||||:|||||||||:|||||||||||||||||||||||||||||.|||||:|||
Zfish  1271 QLQQAGKRVAMVGDGVNDSPALAMADVGIAIGTGTDVAIEAADVVLIRNDLLDVVGSIDLSKKTV 1335

Human  1353 KRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYES 1417
            |||||||||||:|||||||||||||||:||||||||||||||.||||||||||.||.|.|||.|.
Zfish  1336 KRIRINFVFALMYNLVGIPIAAGVFMPVGLVLQPWMGSAAMALSSVSVVLSSLLLKCYTKPTVEK 1400

Human  1418 YELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEP 1482
            .:..........|.|::|||:|:.:..|.||||.||||.|||||||||||.|||.|:||:..|||
Zfish  1401 LKRRLGDVRTHGSLSDVSVHIGMGELRRPSPKLSLLDRFVNYSRASINSLRSDKHSMNSMALSEP 1465

Human  1483 DKHSLLVGDFREDDD 1497
            |||||||||...|::
Zfish  1466 DKHSLLVGDDHCDNE 1480

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.