Protein Alignment ATP7A and Atpalpha

DIOPT Version :10

• Sequence 1: NP_000043.4
• Gene: ATP7A / 538
• HGNCID: 869
• Length: 1500
• Species: Homo sapiens
• Sequence 2: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Alignment Length: 810
• Identity: 173/810 - (21%)
• Similarity: 307/810 - (37%)
• Gaps: 227/810 - (28%)

Human   703 RQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLV 767
            :.:..|.:::..:..:||...       :.|||..:.:....|:.:.|||:..:     ::..:.
  Fly   112 KNLFGGFAMLLWIGAILCFVA-------YSIQASTSEEPADDNLYLGIVLSAVV-----IVTGIF 164

Human   768 AMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQAT---EATIVTLDSDN 829
            :.|:.:|                           ..|..|:...::...||   |...:||.:::
  Fly   165 SYYQESK---------------------------SSKIMESFKNMVPQFATVIREGEKLTLRAED 202

Human   830 ILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM-VDESLITGEAMPVAK-------KPG 886
            ::|            ||:::|..|.:.|.|.|:||..:. ||.|.:|||:.|.::       .|.
  Fly   203 LVL------------GDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPL 255

Human   887 STVIAGSINQN-------GSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPF 944
            .|......:.|       |.::.|..|    |.:.:|..|.....|.:.||.    |...:|:..
  Fly   256 ETKNLAFFSTNAVEGTAKGVVISCGDH----TVMGRIAGLASGLDTGETPIA----KEIHHFIHL 312

Human   945 IVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATP 1009
            |..|::...:.:.||.|:         .||:    ..:.:|   |...|.|..:  |..| |||.
  Fly   313 ITGVAVFLGVTFFVIAFI---------LGYH----WLDAVI---FLIGIIVANV--PEGL-LATV 358

Human  1010 TAVMVGTGVG-AQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVV------NQV---KVLTE 1064
            |..:..|... |....|:|..|.:|.......:..|||||:|.....|      ||:   ....:
  Fly   359 TVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTED 423

Human  1065 SNRISH------HKILAIVGTAESNSEHPLGTAITKYCKQELDTE----TLGTCIDFQVVPGCGI 1119
            .:.:.:      .|.|:.:.|..:.:|...|.......|:|:..:    .|..|::..:
  Fly   424 QSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELAL------ 482

Human  1120 SCKVTNIEGLLHK---------NNWNI-----EDNNIKNASLVQIDASN---EQSST----SSSM 1163
             ..|.||.....|         |.:.:     ||.|.....||...|..   |:.||    ....
  Fly   483 -GDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEK 546

Human  1164 IIDAQISNALNAQQYKV------LIGNREWMI-----RNGLVINNDVNDFMTEHERKGRTAVLVA 1217
            ::|.::..|.|....::      ::|..::|:     .||...|.|..:|..::.|
  Fly   547 VLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLR--------- 602

Human  1218 VDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK---------- 1272
                ..||:::.|..:.....|:...:|.|::|:::|||:..||::||..|||..
  Fly   603 ----FVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIA 663

Human  1273 -------------------------------------------VFAEVLPSHKVAKVKQLQEEGK 1294
                                                       |||...|..|:..|:..|..|.
  Fly   664 QRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGA 728

Human  1295 RVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRIN 1358
            .||:.|||:||||||..|::|:|:| .|:||:.:|||::|:.::...:|..::..|.....::.:
  Fly   729 IVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKS 793

Human  1359 FVFALIYNLVGI-PIAAGVF----MPIGLV 1383
            ..:.|..|:..| |..|.:.    :|:|.|
  Fly   794 IAYTLTSNIPEISPFLAFILCDIPLPLGTV 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7A	NP_000043.4	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219
		HMA	380..443	CDD:238219
		HMA	492..554	CDD:238219
		HMA	567..630	CDD:238219
		P-type_ATPase_Cu-like	652..1388	CDD:319783	173/810 (21%)
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:Q64430	1467..1468
		PDZD11-binding	1486..1500
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:Q64430	1487..1488
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	173/810 (21%)