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Protein Alignment ATP7A and ATP7

DIOPT Version :9

Sequence 1:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens
Sequence 2:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	1289	Identity:	592/1289 - (45%)
Similarity:	798/1289 - (61%)	Gaps:	114/1289 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   277 STATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPG 341
            ||....|.||.|:|||.||...:.....:..:.|.||..:....|:.....|..:...|:.:.
  Fly    12 STVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARIASDIDDMG-- 74

Human   342 LYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVK 406
             :..|...:......:|:|:                .|.|.:.||||.|||::|||.|..|||:.
  Fly    75 -FECSYPGDAADPPETPASA----------------WTNIRVVGMTCQSCVRNIEGNIGTKPGIH 122

Human   407 SIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLL------- 464
            ||.|.||..|..|:|||....|..:...|:||||:|::.:...|    :|..|..|..
  Fly   123 SIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSP----SQSPSPAPASSPKKRAT 183

Human   465 -TSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKA 528
             |.....|.:..:.|....|.:..:||::.:.|||||||||.||::.::..|:.||||||:|.||
  Fly   184 PTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAAKA 248

Human   529 EVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGIL 593
            ||::|..|:....||:.|.||||...:|:..|.|:..:||.:.||||||||:||||.:.|.||:.
  Fly   249 EVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRGVT 313

Human   594 YCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVK-KDRSA-SHLDHKREIRQWRRSFLV 656
            ..||.|.|.:...:|..|..|||.|...||:|||||.|:. :|:.| ::|:||.|||:||.:|||
  Fly   314 TASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKWRNAFLV 378

Human   657 SLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCV 721
            ||.|..|.|..|||.|:            .||.:.    |::|..   ::||||:.||:.|||..
  Fly   379 SLIFGGPCMVAMIYFML------------EMSDKG----HANMCC---LVPGLSMENLVMFLLST 424

Human   722 PVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPM 786
            |||||||::||:|:|:|:||.|.||||||.:.|||::.||:.:::.|:......:|:||||||||
  Fly   425 PVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPM 489

Human   787 LFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVV 851
            |.:||:|||||||||||||||||:||:||:|.:|.:|.:..|..::||:.:.|:.||||||:||:
  Fly   490 LLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVI 554

Human   852 PGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQI 916
            ||.|.||||:|:.|||..||||||||:|||||:.||.||.|||||||.||:.|||.|.:|||:||
  Fly   555 PGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQI 619

Human   917 VKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRT 981
            |:||||||||||||||.||:::||||||:|.||..||:.||:|||.|..:|..... :...:.:.
  Fly   620 VRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HKMHMDQN 683

Human   982 ETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKT 1046
            ..|:.:||:.:::||.|||||:|||||||||||.||.||.||:|:||...||.|||||.||||||
  Fly   684 TIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKT 748

Human  1047 GTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELD------TETL 1105
            ||||||||:.::|.:...:...|..:.|.|||.||.|||||:.:||..:.|..|:      ..:.
  Fly   749 GTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSF 813

Human  1106 GTCIDFQVVPGCGISCKVTNIEGLLHK--------NNWNIEDNNIKNASLVQIDASNE----QSS 1158
            |....||.||||||...|:|.|..|.:        |..|:...:.:.:..|...||.|    |.|
  Fly   814 GKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTHPQGSVPVDNGASIEHLLPQRS 878

Human  1159 TSSSMIIDAQ--ISN--------------ALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHE 1207
            ...||.::.|  :|:              .:::.:..|||||||||.||.:.:..:::|.||..|
  Fly   879 VRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEE 943

Human  1208 RKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK 1272
            |||.||||.|::.:|..:.|::|.|||||.||::.||.||::|||:||||..||.|||.:|||..
  Fly   944 RKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRT 1008

Human  1273 VFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRND 1337
            |:|||||||||||::::|..|.||||||||:|||||||.|:|||.|..|||||.||:|:||:|||
  Fly  1009 VYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRND 1073

Human  1338 LLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVL 1402
            ||||||.:||||.||:|||.||.||.:|||:|||:|:|:|.|.|..|.|||.|.||||||||||.
  Fly  1074 LLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVC 1138

Human  1403 SSLFLKLYRKPT--------YESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLG-------- 1451
            |||.||:|||||        ||:.....|:...:....::|:|.|:||.    |:.|
  Fly  1139 SSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDDL----PEKGRMPFKRSS 1199

Human  1452 --LLDRIVNYSRASINSLLSDKRSLNSVVTSEPD---KHSLLVGDFREDDDTAL 1500
              |:.||..:...:|.|  .|.:....::..|..   :..::...|..:|.|.|
  Fly  1200 TSLISRIFMHDYGNITS--PDAKYGEGLLDPEEQYDGRTKIVRSRFHANDSTEL 1251

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.