Protein Alignment ATP7A and anne

DIOPT Version :10

• Sequence 1: NP_000043.4
• Gene: ATP7A / 538
• HGNCID: 869
• Length: 1500
• Species: Homo sapiens
• Sequence 2: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 1346
• Identity: 248/1346 - (18%)
• Similarity: 448/1346 - (33%)
• Gaps: 492/1346 - (36%)

Human   289 KSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSV-TPESLRKAIEAVSPGLYRVSITSEVE 352
            |:|.|..|:.  .||       ||.|....:|:..|.| |.:.|.      .||   ::..:::.
  Fly     7 KACDSPSETV--HLQ-------SLPNHIEDLKFRNSDVETDDDLH------FPG---IAAKNKIL 53

Human   353 STS--NSP------SSSSLQ-----KIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPG 404
            ..|  :||      ::.|:|     |:|.|.:.:.....|::       |.|         .|..
  Fly    54 KLSWWHSPVDMHYVATESVQPKKSDKVPSNKIKKVENNNTLV-------NGC---------SKTS 102

Human   405 VKSIRVSLANSNGTVEYDPLL--TSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTST 467
            .:|:              |||  ..|:      :|       .|:.|.:..:.:|        :.
  Fly   103 ARSV--------------PLLKYNRPD------QD-------GDSEENITSVLEP--------NV 132

Human   468 NEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRY 532
            :|.|:|      |.|...:.||           .|:..:
  Fly   133 DEIYSK------DSERLVDDSK-----------PCIGLL-------------------------- 154

Human   533 NPAVIQPPMIAEFIREL---GF-GATVIENADEGDGVLELVVRG-------MTCASC-VHKIESS 585
            ||.......:..:.|.|   || .|.:....    |:|.||:..       .||:.| :.:.|..
  Fly   155 NPDQEDQMKVCGYRRSLMRTGFCWACIFLTG----GLLRLVLHWWRHLYLYATCSQCSLEEAEQV 215

Human   586 LT------KHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRS--ASHL- 641
            |.      ||:  :|          |:|.          |..:.|...:..|.|:.:|  .:|:
  Fly   216 LVTEDYQGKHK--MY----------HVKQ----------IQVLTSSNLKTLLEKEQQSIERTHIE 258

Human   642 -DHKREI---------RQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMIN-- 694
             ||...:         .|:::...:.:|.|    ..::|..           |.|.::.:.||
  Fly   259 CDHVENVLQLSVHFTSAQFKKCSSIRIFRC----KQLVYAW-----------NNNTNRFQRINGL 308

Human   695 ----------------LHSS----------------------MFLERQILPGLSVMNLLSFLLCV 721
                            :|..                      :|||  :|....|..|.|.:|
  Fly   309 DLNIPCSYYHQQRGLPVHEQISRRIVFGDNEITVPLRDFKTLLFLE--VLNPFYVFQLFSVIL-- 369

Human   722 PVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPM 786
                   |:.|...|                       |:.:|||::::
  Fly   370 -------WFTYDYYY-----------------------YACVILLMSVF---------------- 388

Human   787 LFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVV 851
                   |..:..:...|..:.|.|.: .....|.:|    |:..||:| :....:..||||::.
  Fly   389 -------GITVSVLQTKKNQDVLQKTV-YNTGNAWVV----DHKGLSKE-LPTRAIVPGDIIEIP 440

Human   852 PGG-KFPVDGRVIEGHSMVDESLITGEAMPVAKKP---GSTVIAGSINQNGSLLICAT------H 906
            ..| ....|..:|.|:.::|||::|||::||.|.|   ...:|..........|.|.|      :
  Fly   441 SSGCTLHCDAILISGNCILDESMLTGESVPVTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRY 505

Human   907 VGADTTLSQIV---KLVEEAQTSKA-----PIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLN 963
            :|:...|:.::   .:..:.:..::     |:....::.|..|:.|:..::        .:||:
  Fly   506 IGSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSYKFIQFLAIIA--------CVGFI- 561

Human   964 FEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKG 1028
            :.:|        ..|.|....::.|.: |:.::.|..|.:|    |.|:.||.....:.   :|.
  Fly   562 YTLV--------TKILRGTDPVKIAVE-SLDLITIVVPPAL----PAAMTVGRFYAQKR---LKT 610

Human  1029 GE-------PLEMAHKVKVVVFDKTGTITH-GTPV--------VNQVKVLTES-----------N 1066
            .|       .:.:|..:....||||||:|. |..:        .||.::..:|           .
  Fly   611 SEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFG 675

Human  1067 RISHHKILAIVGTAESNSEHPLGTAITKYCKQEL-------DTETLGTCIDFQVV---PGCGISC 1121
            .::.|.|..:.|....:   ||...:.:....||       |||..|  |.:..:   |..|:|.
  Fly   676 MVTCHSITILNGRMMGD---PLDLKMFESTGWELEDSNNIPDTEKYG--ILYPTILRQPRGGLSG 735

Human  1122 KVTNIEGLLHKNNWNIEDNNIKNAS-----LVQIDASNEQSSTSSSMIID----------AQISN 1171
            ......|         ..|.||..|     |..:..|..|.:....::.:          :.::.
  Fly   736 MAETESG---------SKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTR 791

Human  1172 ALNAQQYKVLIGNREWMIR---NGLVINNDVNDFMTEHERKGRTAVLVA---------------- 1217
            .|:.|.:.|.......|::   ....:.::.:..::|..:||...:.:|
  Fly   792 CLSDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALSHKMNYTKVQRL 856

Human  1218 ----VDD--ELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAE 1276
                |::  |..|.:.:.:.:||:....|:.|.:..:..:::||||..||.|:|...||
  Fly   857 SREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGI------ 915

Human  1277 VLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDV 1341
            |.||..|            :.:..|.|.||     ||  |...|||:...:.:.     :....:
  Fly   916 VSPSQSV------------ITVHADPIGDS-----AN--IQTNTGTECNFDNSS-----DKHYKL 956

Human  1342 VASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLF 1406
            ..::||..||.:.    ::|...:|       :.:|.|........:|.......|.:.:::.
  Fly   957 HYTLDLGSKTSRA----YLFKSCFN-------SNLFDPETPEFTAQVGKTIFHMESTNSLVNE-- 1008

Human  1407 LKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGL 1452
                ...:|....||.       |.|..||.. ||..:.|..:||:
  Fly  1009 ----STSSYAESGLPT-------SDSLASVKT-IDTWTHNDAELGI 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP7A	NP_000043.4	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219	14/48 (29%)
		HMA	380..443	CDD:238219	9/64 (14%)
		HMA	492..554	CDD:238219	7/65 (11%)
		HMA	567..630	CDD:238219	14/76 (18%)
		P-type_ATPase_Cu-like	652..1388	CDD:319783	159/870 (18%)
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:Q64430	1467..1468
		PDZD11-binding	1486..1500
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:Q64430	1487..1488
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	31/178 (17%)
		P-type_ATPase_cation	326..1281	CDD:319842	166/874 (19%)