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Protein Alignment ATP7A and cua-1

DIOPT Version :10

Sequence 1:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens
Sequence 2:	NP_001255202.1	Gene:	cua-1 / 176770	WormBaseID:	WBGene00000834	Length:	1238	Species:	Caenorhabditis elegans

Alignment Length:	1247	Identity:	565/1247 - (45%)
Similarity:	775/1247 - (62%)	Gaps:	98/1247 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   283 IDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSI 347
            |.||.|.|||.||:..:.|...:.||.|:|:..:|...::.:..|.|.:.:|::         .:
Worm    53 IKGMTCNSCVKNIQDVIGAKPGIHSIQVNLKEENAKCSFDTTKWTAEKVAEAVD---------DM 108

Human   348 TSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSL 412
            ..:.:.....|        |..:..:|..:..:::|:||||::||.:|:..:..|.|:..|.|||
Worm   109 GFDCKVLKKEP--------PTQMAEKPKIRRAIVSIEGMTCHACVNNIQDTVGSKDGIVKIVVSL 165

Human   413 ANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSE-----MPLLT-----ST 467
            ....|||:|:....:.|::..:|:|||||..|....|...|..|.:|.     .||.|     ..
Worm   166 EQKQGTVDYNSEKWNGESVAESIDDMGFDCKLITDQEIAAVEPQKASTTKLSISPLKTVDLSDGK 230

Human   468 NEFYTKGMTPVQDKEEGKNS--SKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEV 530
            .|....|   |:..:||.:.  .||...|.||||||||..||||:.:.||::||:|||:|.||||
Worm   231 VELQLNG---VKYSKEGSSDHLEKCTFAVEGMTCASCVQYIERNISKIEGVHSIVVALIAAKAEV 292

Human   531 RYNPAVIQPPMIAEFIR-ELGFGATVIEN--ADEGDGVLELVVRGMTCASCVHKIESSLTKHRGI 592
            .|:..|.....|.|.:. |||:.||::::  |:.....:.|::..::..|..::|||.:....||
Worm   293 IYDGRVTSSDAIREHMTGELGYKATLLDSMGANPNYSKIRLIIGNLSTESDANRIESHVLSKSGI 357

Human   593 LYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVS 657
            ..|:|::||:.|.:::.|::|||||||:.:|||||.|.|..:|.....|||..::::||.:|.::
Worm   358 DSCNVSIATSMALVEFSPQVIGPRDIINVVESLGFTADLATRDDQMKRLDHSDDVKKWRNTFFIA 422

Human   658 LFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQ---ILPGLSVMNLLSFLL 719
            |.|.:|||.:||..     |:.               |.:.|..::|   ..|.||:.|.|...|
Worm   423 LIFGVPVMIIMIIF-----HWI---------------LRTPMHPDKQTPIFTPALSLDNFLLLCL 467

Human   720 CVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTP 784
            |.|||.|||.|||:.::||:||..|||||||:|:||||:.||:::||:|:..:...:|:||||.|
Worm   468 CTPVQIFGGRYFYVASWKAIKHGNANMDVLIMLSTTIAYTYSIVVLLLAIIFKWPSSPMTFFDVP 532

Human   785 PMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIK 849
            |||.|||||||.|||.|||||||||:||:||||.|||:||:||:..|.||:.:::|||||.|:||
Worm   533 PMLIVFIALGRMLEHKAKGKTSEALSKLMSLQAKEATLVTMDSEGRLTSEKGINIELVQRNDLIK 597

Human   850 VVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLS 914
            ||||.|.||||.|::|.|.||||.||||:|||.||||||||.||:||.|.|::.|||||.|:|||
Worm   598 VVPGAKVPVDGVVVDGKSSVDESFITGESMPVVKKPGSTVIGGSVNQKGVLIVKATHVGNDSTLS 662

Human   915 QIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSIS 979
            |||:|||||||::|||||.|||::||||||::.:|:.||.|||.|         .|....|.::.
Worm   663 QIVRLVEEAQTNRAPIQQLADKIAGYFVPFVIVLSLFTLGVWIYI---------EYNSARNANLP 718

Human   980 ---RTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVV 1041
               |.|..::.||:|:||||.|||||||||||||||||||||||.||||||||||||..|||..:
Worm   719 PGLRFEEALKIAFEAAITVLAIACPCSLGLATPTAVMVGTGVGAANGILIKGGEPLESVHKVTTI 783

Human  1042 VFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLG 1106
            |||||||||.|.|.|.|:......:.:|...|..:.|..|:.||||:|.|:..:.||.|:..|..
Worm   784 VFDKTGTITEGRPRVVQIASFVNPSTMSLKLITFLSGATEALSEHPIGNAVAAFAKQLLNEPTWP 848

Human  1107 TCIDFQVVPGCGISCKVTNIE---GLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQ 1168
            ....|.|..|.|::|::.:|.   ..|..:....|...:.:...:.|..:.......||    .:
Worm   849 NTSRFHVSAGHGVTCRIDSIRQSFSSLALSGSTCEIPRLPDGQTITIPGTEVNLLQVSS----KE 909

Human  1169 ISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVK 1233
            :|.. |.....::||....|.|:|:.::..|...::|.:|||..:|:.|::.|:..:|:|||.||
Worm   910 VSQP-NPDTANIVIGTERMMERHGIPVSEVVKMTLSEEQRKGHISVICAINAEVVAVISIADQVK 973

Human  1234 PEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAM 1298
            .||.|||:.|:.|||.|||:||||||||.|.|.||||.:|||||||:.|..|:|||:....:|||
Worm   974 KEASLAIYTLREMGLRVVLLTGDNSKTAESTAKQVGIDEVFAEVLPNQKQQKIKQLKGYKNKVAM 1038

Human  1299 VGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFAL 1363
            ||||:|||||||.|||||||..|:|||||:|.:||:||||:|||.:|.||:.|.:|||:||:||:
Worm  1039 VGDGVNDSPALAEANVGIAIAAGSDVAIESAGIVLVRNDLVDVVGAIKLSKMTTRRIRLNFLFAI 1103

Human  1364 IYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPA--RSQI 1426
            |||.:|||||||||.|.|.:|||||.:||||.||||||.|||.||.:||||..:....:  |.|.
Worm  1104 IYNAIGIPIAAGVFRPFGFMLQPWMAAAAMALSSVSVVSSSLLLKNFRKPTIANLYTTSFKRHQK 1168

Human  1427 GQKSPS-EISVHVGIDDTS----RNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHS 1486
            ..:|.| ::.||.|:||::    ..|.||.:|.       :.:.|||.   |..|:|:|...|..
Worm  1169 FLESGSFQVQVHRGLDDSAVFRGAASSKLSILS-------SKVGSLLG---STTSIVSSGSSKKQ 1223

Human  1487 LL---VGDFRED 1495
            .|   ||...||
Worm  1224 RLLDNVGSDLED 1235

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.