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Protein Alignment ATP7A and atp7a

DIOPT Version :10

Sequence 1:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens
Sequence 2:	NP_001361526.1	Gene:	atp7a / 100170482	XenbaseID:	XB-GENE-1010489	Length:	1501	Species:	Xenopus tropicalis

Alignment Length:	1508	Identity:	1035/1508 - (68%)
Similarity:	1217/1508 - (80%)	Gaps:	37/1508 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    12 ISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIH 76
            |.||||||||||.||||:||.:||||.||||||.|||.||||.||||||.||||::||||::.:.
Frog    12 IPVEGMTCNSCVQTIEQKIGSINGVHSIKVSLEGKNAAIIYDAKLQTPKALQEAVEDMGFESTLS 76

Human    77 NPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKE 141
            ..:|.||..|:.||.::|..:.  :.|:|.|.:.|||.|:|...:.:...||.|||:||...:.:
Frog    77 YANPQPVPMDSTFLRLSAEQSA--EQIRSGLSQFKGVLDVKTSLEGKVACVTFIPSVVNPGLLIQ 139

Human   142 LVPELSLDTGTLEK-KSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVS 205
            .:|.||||:...:| .||:.|..| :.|.:|::|||:|||||||||||||||:|||:||||||||
Frog   140 KIPGLSLDSMASKKTTSGSVESRS-SVASDVLVKMKIEGMTCHSCTSTIEGKVGKLKGVQRIKVS 203

Human   206 LDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRS 270
            ||:|||.|:||||||..|:::.|||..||.|.:|.:|.. ||||||:|||.||...|:....|:.
Frog   204 LDSQEAQILYQPHLIKPEDIRTQIEEAGFIAQIKSKPPQ-KLGAIDIERLTNTQTNSNGDLPQKI 267

Human   271 PSYTND-STATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKA 334
            |.:.|| ..|.|.|:||||||||.||||.:.:...||||.|||||:.|::.:.::..|.::|.:|
Frog   268 PKHQNDLIRAIFQIEGMHCKSCVVNIESNIGSQHGVSSIEVSLENKLAVIHFYSNITTSDALIQA 332

Human   335 IEAVSPGLYRVSITSEVE------STSNSPSSSSLQKIPLNVVSQPLTQE-----TVINIDGMTC 388
            |||:|||.::||:.:..|      ...||.:|.:.:     :.|.|..|:     |||||:||||
Frog   333 IEALSPGTFKVSLCNHPELAETFSMQKNSEASCAKE-----IFSSPSNQDFCSKVTVINIEGMTC 392

Human   389 NSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVV 453
            .||||||||:||||||||||:|||.|:||||:|||.:||||.:|.|||||||||:|.........
Frog   393 MSCVQSIEGLISKKPGVKSIQVSLVNNNGTVQYDPAVTSPEDIRAAIEDMGFDASLLANTGQADA 457

Human   454 IAQPSSEMPLLTS------TNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRR 512
            ....:|:.|.|.|      ||:     .|||..|.|.:..:||:||:||||||||||||||||||
Frog   458 FTSEASQKPFLNSLLPKERTNK-----ETPVHSKPEKRTVNKCFIQITGMTCASCVANIERNLRR 517

Human   513 EEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCAS 577
            ||||||:|||||||||||||||.|:||..|||.|:||||.|:|:||.|:|.|:|||:||||||||
Frog   518 EEGIYSVLVALMAGKAEVRYNPEVLQPSGIAELIQELGFEASVLENYDDGTGILELLVRGMTCAS 582

Human   578 CVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLD 642
            |||||||.|.|.:|:||.||||||||||||:|||:||||||:..|..|||..|||||||||||||
Frog   583 CVHKIESRLMKTKGVLYSSVALATNKAHIKFDPEVIGPRDIMKIINDLGFSTSLVKKDRSASHLD 647

Human   643 HKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILP 707
            |:.||::|:||||:||.|||||||||::||.|::|:...||: ||:.|::.:.|.:|.||.||:|
Frog   648 HRVEIQRWKRSFLISLIFCIPVMGLMVHMMFMENHYLMPHHH-NMTMEDIASYHPTMVLEYQIIP 711

Human   708 GLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYER 772
            |||:|||:|.|||:||||.|||||||||||||||:||||||||||||::||.||||:|:||::|:
Frog   712 GLSIMNLVSLLLCIPVQFLGGWYFYIQAYKALKHRTANMDVLIVLATSVAFIYSLIVLIVAIFEK 776

Human   773 AKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQV 837
            :|||||||||||||||||||||||||||||.||||||::||||||||||:|.||.||.:.|||||
Frog   777 SKVNPITFFDTPPMLFVFIALGRWLEHIAKSKTSEALSRLISLQATEATVVILDPDNTVKSEEQV 841

Human   838 DVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLI 902
            ||||||||||::|.||||||||||||||.|||||||||||||||:|||||:||||||||||||||
Frog   842 DVELVQRGDIVRVTPGGKFPVDGRVIEGQSMVDESLITGEAMPVSKKPGSSVIAGSINQNGSLLI 906

Human   903 CATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIV 967
            .|||||:||||||||||||:||||||||||||||||||||||||.||:.||.|||:||:.|||||
Frog   907 AATHVGSDTTLSQIVKLVEDAQTSKAPIQQFADKLSGYFVPFIVAVSVLTLFVWIIIGYHNFEIV 971

Human   968 ETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPL 1032
            |.||||||:|||:.|.|:||||||:||||||||||||||||||||||||||||||||||||||||
Frog   972 EKYFPGYNKSISKGEVIVRFAFQAAITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPL 1036

Human  1033 EMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCK 1097
            |||||||.||||||||||.|||||.|||||.||||:..:|:||||||||||||||||:|:.||||
Frog  1037 EMAHKVKTVVFDKTGTITKGTPVVMQVKVLVESNRMPSNKLLAIVGTAESNSEHPLGSAVIKYCK 1101

Human  1098 QELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSS 1162
            :.|:.||||||.|||.||||||||||.|||.|||..|   ..:|.:||.|||||..:|.|...|.
Frog  1102 EVLNAETLGTCYDFQAVPGCGISCKVNNIEPLLHAAN---GPDNKRNAVLVQIDGQHEDSILPSI 1163

Human  1163 MIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIA 1227
            .:.....:.:...|.|.|||||||||.||.|.:..:.:..|||||:|||||||||||..||||||
Frog  1164 TVSQNPSNGSSPPQTYSVLIGNREWMNRNFLTLTAETDSLMTEHEKKGRTAVLVAVDGVLCGLIA 1228

Human  1228 IADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEE 1292
            |||||||||.||||.|:||||::|||||||||||::||:|||||||||||||||||||||||||:
Frog  1229 IADTVKPEAALAIHSLRSMGLDIVLMTGDNSKTAKTIAAQVGITKVFAEVLPSHKVAKVKQLQEQ 1293

Human  1293 GKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRI 1357
            |.||||||||||||||||||:|||.||:|||||||||||||||||||||||||||||||||||||
Frog  1294 GTRVAMVGDGINDSPALAMADVGITIGSGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRI 1358

Human  1358 NFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPA 1422
            ||||||||||||||||||||||:||:||||||||||||||||||.|||.|||||||:.|..|...
Frog  1359 NFVFALIYNLVGIPIAAGVFMPVGLILQPWMGSAAMAASSVSVVFSSLLLKLYRKPSREKLEQRV 1423

Human  1423 RSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSL 1487
            :.|:.|||.|:||||:|:.:..|.|.||.||||||||||||:||.||||.|.:|:..||||||||
Frog  1424 QGQMRQKSLSDISVHIGLTENRRTSTKLDLLDRIVNYSRASLNSFLSDKHSQHSIPLSEPDKHSL 1488

Human  1488 LVGDFREDDDTAL 1500
            |:|:.:.::||.|
Frog  1489 LLGELKGEEDTFL 1501

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.