Protein Alignment ATP6AP1 and VhaAC45

DIOPT Version :10

• Sequence 1: NP_001174.2
• Gene: ATP6AP1 / 537
• HGNCID: 868
• Length: 470
• Species: Homo sapiens
• Sequence 2: NP_610470.1
• Gene: VhaAC45 / 35944
• FlyBaseID: FBgn0262515
• Length: 379
• Species: Drosophila melanogaster
• Alignment Length: 471
• Identity: 112/471 - (23%)
• Similarity: 179/471 - (38%)
• Gaps: 122/471 - (25%)

Human    20 LWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPAADTHEGHITSDLQLSTYLDPALEL 84
            ||:.       .:|.....||..:|.|:.||.:: .:..|:..|     .|.::.:..|...||
  Fly     2 LWKS-------LIALCVIGAAVAEQTPVFLWGAN-SVAKPSLKT-----VSQVEFAEQLAALLE- 52

Human    85 GPRNVLLFLQDKLSIEDF--------TAYGGVFGNKQDSAFSNLEN---ALDLAPSSLVLPAVDW 138
             ...|:.|.::.||.:||        :.|..:.|....:.::::||   ||....:.....::|
  Fly    53 -DHMVVAFEENGLSSKDFLCSNSQAQSCYAQLQGVSPKTYYTSVENPSEALRSVAAKREHNSID- 115

Human   139 YAVSTLTTYLQEKLGASPLHV---DLATLRELKLNASLPALLLIRLPYTASSGLMAPREVLTGND 200
             |...|||..:..:|.: |.|   |.|..||..|.:...|:..|...:......:
  Fly   116 -ASGKLTTPAKCAVGTA-LFVTFEDAAESREASLESHDAAIAAISKQFECKVAYL---------- 168

Human   201 EVIGQVLSTLKSEDVPYTAA--LTAVRPSRVARDVAVVAGGLGRQLLQKQPVSPVIHPPVSYNDT 263
                            |.||  ...|...|..||.|...||
  Fly   169 ----------------YLAAPSTAPVVQRRTRRDTAATTGG------------------------ 193

Human   264 APRILFW--AQNFSVAYKDQWEDLTPLTFGVQELNLTGSFWNDSFARLSLTYERLFGTTVTFKFI 326
                :.|  ...|.:.|.....:..|:|  |.:|.||    |.|..:||:..:    |:|..|.|
  Fly   194 ----IMWKSTNQFQIFYTALLYNGNPIT--VTDLKLT----NSSSTKLSVVMD----TSVADKPI 244

Human   327 LANRLYPVSARHWFTMERLEVHSNGSVAYFNASQVTGPSIYSFHCEYVSSLSKKGSLLV--ARTQ 389
            ..:.:|...   :|::..| |:.|.:   |.:|.|..|:.:|:.|         |:|.:  |...
  Fly   245 TFDVVYNGG---YFSLSNL-VYDNNN---FRSSGVNAPTTFSYSC---------GNLTLESAAVN 293

Human   390 PSPWQMMLQDFQIQA-FN-VMGEQFSYAS--DCASFFSPGIWMGLLTSLFMLFIFTYGLHMILSL 450
            .....:..:..|:|| |: ...|.|.:..  ||..|.:|||.|||.....:|.|...|:..::.:
  Fly   294 NMYNTLSFKSLQLQAPFDGTYKEDFPFGDSWDCVGFVTPGILMGLFVVALLLVIMFVGVCWMMDI 358

Human   451 KTMDRFDDHKGPTISL 466
            .|||||||.||.||::
  Fly   359 NTMDRFDDPKGKTITI 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6AP1	NP_001174.2	VAS1_LD	265..405	CDD:461752	34/144 (24%)
		Ac45-VOA1_TM	420..458	CDD:466669	15/37 (41%)
VhaAC45	NP_610470.1	Lamp	211..309	CDD:480752	30/123 (24%)
		Ac45-VOA1_TM	328..366	CDD:466669	15/37 (41%)