Protein Alignment ATP6AP1 and VhaAC45RP

DIOPT Version :10

• Sequence 1: NP_001174.2
• Gene: ATP6AP1 / 537
• HGNCID: 868
• Length: 470
• Species: Homo sapiens
• Sequence 2: NP_001036775.1
• Gene: VhaAC45RP / 318563
• FlyBaseID: FBgn0051030
• Length: 423
• Species: Drosophila melanogaster
• Alignment Length: 353
• Identity: 82/353 - (23%)
• Similarity: 129/353 - (36%)
• Gaps: 106/353 - (30%)

Human   146 TYL-QEKLGASPLHVDLATLRELKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVI-----G 204
            ||| |..|.|.|          ..|||::..:.|      :..|.....|:|...:|.:     |
  Fly    90 TYLPQRSLAAEP----------FGLNANIEVVSL------SGHGEEDDSEILLAYNEAVNTYGRG 138

Human   205 QVLSTLKS-EDVPYTAALTAVRPSRVARDVAVVAGGLGRQLLQKQPVSPVIHPPVSYNDTAPRIL 268
            :||..|.| |:..:..|.....|.....:.|..|.|                    ..:|....:
  Fly   139 EVLGILGSREEEAHFLAKREAAPGGEEEEKAKAAEG--------------------SEETEASFI 183

Human   269 FWAQ-NFSVAYKDQWEDLTPLTFGVQELNLTGSFWNDS-------------------FARLSLTY 313
            :.|: |.:|...:          |..||.:|    ||:                   :.|||:|:
  Fly   184 YVAEGNKAVLSLN----------GPLELRVT----NDTLKLEEHIKQITFDDQRAKGYGRLSITF 234

Human   314 ----ERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSN--GSVAYFNASQVTGPSI---YSF 369
                |:   .|:.|||.|        .|..:|:..:||...  .||......:.|.||.   :|:
  Fly   235 MHSGEK---CTLRFKFSL--------IRGSWTLRNVEVEYRELKSVLVARGDEYTLPSAPLGFSY 288

Human   370 HC--EYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCASFFSPGIWMGLLT 432
            .|  |.|:.|:.      ||.: :...::|.|||:|.:.....::....||..|.|..|..||..
  Fly   289 RCSAESVNFLNP------ARNE-TIQSLLLSDFQVQPWLNGRPEYGEVYDCIGFVSAPILAGLFV 346

Human   433 SLFMLFIFTYGLHMILSLKTMDRFDDHK 460
            ...:|.|...|:..:||:.|.:||:..:
  Fly   347 VTLLLGILGLGISAMLSMHTPNRFESSR 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6AP1	NP_001174.2	VAS1_LD	265..405	CDD:461752	40/170 (24%)
		Ac45-VOA1_TM	420..458	CDD:466669	13/37 (35%)
VhaAC45RP	NP_001036775.1	Lamp	<242..319	CDD:480752	26/91 (29%)