Protein Alignment PLXNB3 and PlexB

DIOPT Version :10

• Sequence 1: NP_001156729.1
• Gene: PLXNB3 / 5365
• HGNCID: 9105
• Length: 1932
• Species: Homo sapiens
• Sequence 2: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Alignment Length: 2136
• Identity: 659/2136 - (30%)
• Similarity: 1030/2136 - (48%)
• Gaps: 360/2136 - (16%)

Human    50 LCLLLLL-----------------LSP----------PPLPLTG---------------AHRFSA 72
            ||::::|                 |||          |.:|:..               :.|.|.
  Fly    18 LCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVRDSQ 82

Human    73 PNTTLNHLALAPGRGTLYVGAVNRLFQLSPELQLEAVAVTGPVIDSPDCVPFRDPAECP---QAQ 134
            ......|::.......|:.||.|::.:|:..|::.|.|||||:.|||.|    ....||   :..
  Fly    83 SKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQC----HAGGCPEDIETS 143

Human   135 LTDNANQLLLVS-SRAQELVACGQVRQGVCETRRLGDVAEVLYQAEDPGDGQF----VAANTPGV 194
            |.:|.|::|:|| :....|:|||.:|||.||...|         ...|...||    :|||....
  Fly   144 LVNNFNKILVVSYAHDGILIACGSIRQGACEIYSL---------PRFPATPQFFAVPLAANDENA 199

Human   195 ATVGLVVPL----PGRDLLLVARGL--AGKLSAGVPPLAIRQLAGSQPFSSEGLGRLVVGDFSDY 253
            :|...|.|.    ...|:|.|....  .|.....||.::.|:| ....::...:.:.::.....|
  Fly   200 STYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL-DDLNYAEFSIQQSIINIDVKY 263

Human   254 NN----SYVGAFADARSAYFVFRRRGARA--QAEYRSYVARVCLGDTNLYSYVEVPLACQG---- 308
            .:    .|:..|..:..|||:..::.:..  :|.|.:.:||:|:.|.|..||.|:.:.|..
  Fly   264 RDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSYTEITVQCTATENN 328

Human   309 --QGLIQAAFLAPGT---------------LLGVFA-----AGPRGTQAALCAFPMVELGASMEQ 351
              ..:::.|.:.|.:               |:.||:     :....:::|:|.:.:.::.....:
  Fly   329 VDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSIKDIEDMFIE 393

Human   352 ARRLCYTAGGRGPS-GAEEATVEYGVTSRC-VTLPLDSPESYPCGDEHTPSPIAGRQPLEVQPLL 414
            ...||:....:..: |....|:..|   || :...|.:..:: |.   ....|:|..|:....|.
  Fly   394 NIHLCFNGTTKDRNLGYISGTINDG---RCPIVGSLGNIYNF-CS---VGLKISGVSPITAHALF 451

Human   415 KLGQ-PVSAVAALQA--DGHMIAFLGDTQGQLYKVFLHG-SQGQVYHSQQVGPPGSAISPDLLLD 475
            .... .|::|.|...  ..|.:||||...|.:.||.|.| |.|:  :.:.|...|:.|.|:.::.
  Fly   452 HFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGE--YEEIVVDAGNRILPNTMMS 514

Human   476 SSGSHLYVLTAHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGRAGQLNQWLW 540
            .....||||:..::.::.:..|..:.:|::||:::||.||||.|:.|||.:..|.|....::||
  Fly   515 PKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWL- 578

Human   541 SYEEDSHCLHIQSLLPGHHPRQEQGQVTLSVPRLPILDADEYFH----CAFGDYDSL-AHVEGPH 600
            |......|:..:|::|...|..|...:.|.:..||     |.|:    |.||:...: |.:....
  Fly   579 SLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLP-----EPFNAKYRCVFGNSTPIDAEILENG 638

Human   601 VACVTPPQDQVPLNPPGTDHVTVPLALMFEDVT--VAATNFSFYDCSAVQALEAAAPCRACVGSI 663
            :.|.|||.|:.||.|..|||:.|||::...:..  ..:.||:|:|||      ....|:.|:.|.
  Fly   639 LGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCS------HHGNCQECLQSS 697

Human   664 WRCHWCPQSSHCVYGEHCPEGERTIYSAQEVDIQVRGPGACPQVEGLAGPHLVPVGWESHLALRV 728
            |.|:||...:.||:..         ...:.::..|...|.||.::......|:||.....:.|.:
  Fly   698 WGCNWCIFDNKCVHKS---------LQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEI 753

Human   729 RNLQHFRGLPASFHCWLELPGELRGLPATLEETAGDSGLIHCQAHQFYPSMSQRELPVPIYVTQG 793
            .||...:...|.|.|.:.:......|||.:|    .:.::.|:...::..::..|....:.||..
  Fly   754 ENLPKPKSAHAGFLCTIHIEAAQMLLPAHVE----SNKIVVCEKTPYFYEINTHEYQAKVVVTWN 814

Human   794 EAQRLDNTHALYVILYDC-AMG----HPDCSHCQAANRSLGCLWCADGQPACRYGPLC------- 846
            ....:|..   .|.||.| .:|    |||||.|...:....|.||::   :|.|...|
  Fly   815 FQHYVDTA---IVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSN---SCVYNETCIADKNSI 873

Human   847 ---PPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLY 908
               ...|:|..||.|.||.::||:||.|||..:||.|||||....||:..:.:.|.||..|.  |
  Fly   874 SSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELEN--Y 936

Human   909 RTSARIVCVTSPAPNGTTGPVRVAIKSQPPGI--SSQHFTYQDPVLLSLSPRWGPQAGGTQLTIR 971
            :.|.:|.|.|..:....:.|::||   ...|.  ||..|.:::.:|..|.|..||::|||||::.
  Fly   937 QISVKIECRTGASLYEMSAPIKVA---NDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLI 998

Human   972 GQHLQTGGNTSAFVGGQPCPI-LEPVCPEAIVCRT--RPQAAPGEAAVLVVFGHAQRTL---LAS 1030
            |:.|..|....||:....|.| :.......:.|.|  ..|..|..:..||:.| |.|||   :::
  Fly   999 GKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDG-ANRTLECQIST 1062

Human  1031 P---------------------------FRYTANPQLVAAEPSASFRGGGRLIRVRGTGLDVVQR 1068
            |                           |.||.:|:::..:|..||:.|||::.|.|..|:.:|:
  Fly  1063 PSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQK 1127

Human  1069 PLLSVW---------------------------------------LEADAEVQASRAQPQ----- 1089
            |.|.|:                                       ::.:..:|.|..|.:
  Fly  1128 PELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKN 1192

Human  1090 --DPQPRRSCGAPAADPQACIQLGGGL--------LQCSTVCSVNSSSLLLCRSPAVPDRAHPQR 1144
              |.:.||   |...|........|..        :..:|...|:.:.|.|             :
  Fly  1193 EYDRKKRR---ADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNL-------------Q 1241

Human  1145 VFFTLDNVQV---------DFASASGGQGFLYQPNPRLAPLSREGPARPYRLKPGHVLDVEGEGL 1200
            :.|.:||||:         |..|.     .:|..:|:..|...:|    .:|..|..|.:|||.|
  Fly  1242 LSFVMDNVQLVRNLNKYFHDIRST-----IVYLADPKYLPFPNDG----VKLYKGDSLVIEGELL 1297

Human  1201 NLGISKEEVRVHIGRGECLVKTLTRTHLYCEPPAHAPQPANGSG------LPQFVVQMG-NVQLA 1258
            ||...:.:|.|.||..:|.:.:|....|.|.||...|.|.:.:|      ||..||::| |::..
  Fly  1298 NLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFV 1362

Human  1259 LGPVQYEAEPPLSAFPVEAQAGVGMGAAVLIAAVLLLTLMYRHKSKQALRDYQKVLVQLESLETG 1323
            :|.::|:...|. .|......|: :..|:|:...:::.:::|.||.||.|:|:::.:|:.:||:.
  Fly  1363 IGYLKYDLNKPY-VFSHALLVGI-LTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESN 1425

Human  1324 VGDQCRKEFTDLMTEMTDLSSDLEGSGIPFLDYRTYAERAFFPGHGGCPLQPKP---EGPGEDGH 1385
            |..:|::.|.:|.|:||||::|||.:|||.||:..|..:.||||....|:...|   ||..:..:
  Fly  1426 VRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNY 1490

Human  1386 CATVRQGLTQLSNLLNSKLFLLTLIHTLEEQ-PSFSQRDRCHVASLLSLALHGKLEYLTDIMRTL 1449
            .|    .:.|...|:.:|.|||..|.|||.| .|||.|||.:||||:.:.|..|:||.|:|:::|
  Fly  1491 DA----AMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSL 1551

Human  1450 L-----GDLAAHYVHRNPKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLYMLFRAIQYQVD 1509
            |     ..||:    ::|:|||||||::|||:|||:|:||:|.:|:|.||..|::||:||::|::
  Fly  1552 LLRLIDKSLAS----KHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIE 1612

Human  1510 KGPVDAVTGKAKRTLNDSRLLREDVEFQPLTLMVLVGPGAGGAAGSSEM-QRVPARVLDTDTITQ 1573
            ||.|||:|..|:.:|::.|||.|.|....:.|.:|          ..:: ::|..||.|.|||:|
  Fly  1613 KGLVDAITNDARYSLSEERLLHEQVTHSVVILHIL----------QDDLDEKVQCRVNDWDTISQ 1667

Human  1574 VKEKVLDQVYKGTPFSQRPSVHALDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDG 1638
            ||.|:||.::|.||||.||||:.:|||||.|..|||||.|||||:.|.|.|||||||.||.|.:.
  Fly  1668 VKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKES 1732

Human  1639 ATVGLVPQLHRGSTISQSLAQRCPLGENIPTLEDGE---------EGGV---CLWHLVKATEEPE 1691
            |.:.|:.:.:....|..|..|......|...:.:.:         |.|:   .::||||......
  Fly  1733 AVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDH 1797

Human  1692 GAKVRCSSLREREPARA------------KAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPI 1744
            ...::.|.|....||..            |.|||:||||||:.|||:||||||.|..||:||..:
  Fly  1798 YMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVNEEL 1862

Human  1745 PIAVKYLFDLLDELAEKHGIEDPGTLHIWKTNSLLLRFWVNALKNPQLIFDVRVSDNVDAILAVI 1809
            |.|||:|||||||.|.:|.|.|...:|.||:|.|.||||||.:|||..||||..:.:||:.|:||
  Fly  1863 PPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVI 1927

Human  1810 AQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAELSGN 1874
            ||||:|:|:||||::|:|||.||||:|::||.|:.||:.:|.|:.:....|.|||::|:.:||..
  Fly  1928 AQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVR 1992

Human  1875 YTSAPHCLEALQELYNHIHRYYDQIISALEEDPVGQKLQLACRLQQVAALVENKVT 1930
            .......:.||:|||.:|.:|.|||:.:||.|...:|:.|:.:|..|||.::...|
  Fly  1993 QNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGDCT 2048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLXNB3	NP_001156729.1	Sema_plexin_B3	70..495	CDD:200538	113/476 (24%)
		PSI	497..548	CDD:396154	19/50 (38%)
		TIG_plexin	556..642	CDD:465588	28/92 (30%)
		PSI	656..690	CDD:396154	9/33 (27%)
		TIG_2	712..809	CDD:465619	19/96 (20%)
		IPT_plexin_repeat1	858..949	CDD:238585	35/92 (38%)
		IPT_plexin_repeat2	950..1035	CDD:238584	30/117 (26%)
		IPT	1038..1169	CDD:472823	35/193 (18%)
		TIG	<1199..1265	CDD:460355	23/72 (32%)
		Plexin_cytopl	1350..1894	CDD:462434	256/577 (44%)
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	112/470 (24%)
		PSI	535..586	CDD:396154	19/51 (37%)
		TIG_plexin	594..682	CDD:465588	28/92 (30%)
		PSI	683..730	CDD:214655	14/61 (23%)
		TIG_2	738..827	CDD:465619	19/95 (20%)
		PSI	836..877	CDD:214655	12/43 (28%)
		IPT_plexin_repeat1	888..976	CDD:238585	35/92 (38%)
		IPT_plexin_repeat2	977..1095	CDD:238584	31/118 (26%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	22/116 (19%)
		TIG	1277..>1334	CDD:460355	20/60 (33%)
		Plexin_cytopl	1452..2012	CDD:462434	256/577 (44%)