Protein Alignment PLXNB1 and PlexA

DIOPT Version :10

• Sequence 1: XP_011532135.1
• Gene: PLXNB1 / 5364
• HGNCID: 9103
• Length: 2136
• Species: Homo sapiens
• Sequence 2: NP_524637.2
• Gene: PlexA / 43832
• FlyBaseID: FBgn0025741
• Length: 1945
• Species: Drosophila melanogaster
• Alignment Length: 2234
• Identity: 700/2234 - (31%)
• Similarity: 1036/2234 - (46%)
• Gaps: 509/2234 - (22%)

Human    33 TYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECP---QAQPT 94
            |.|.||..|..:|.:::|..|.|:||||.|:|..||.|||..||.:|  .::  :||   ...||
  Fly    73 TKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SIL--DCPLNAVRSPT 133

Human    95 NNPNQLLLV--SPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVA 157
            :|.|::||:  :...|:.|||:.||.|..|.|..:.  ::..|.|   ..|.|||...|||..:|
  Fly   134 DNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVS--IIEHEVP---DAVVANDANSSTVAFIA 193

Human   158 QGLAGEP---LLFVGRGYTSRG-VGGGIPPITTRALWPPDPQAAFSYEETA--KLAVGRLSEYSH 216
            .|....|   :::||..||:.. ....||.:.:|:|           |:|.  ::|...::..:.
  Fly   194 PGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL-----------EKTKMFQIASSAVTTGTR 247

Human   217 HFVSAFAR---------GAS----AYFLF--LRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPL 266
            .|::::||         |.|    :|||.  |:....:..:.:...:.|:|..|.:||||.|:|:
  Fly   248 TFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPV 312

Human   267 AC----EGG-RYGLIQAAAVA-TSREVAHG-------EVLFAAFSSAAPPTVGRPPSAAAGASGA 318
            .|    :|| ::.|:||..:. .|.::|..       :||||.||...    |..|      :..
  Fly   313 ECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGE----GNTP------TNN 367

Human   319 SALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEY-DVNSDCAQLPVDTLDAYPCGSDHT 382
            ||||.:.|..:.|...:...:|:       :|:.:..::: ..:..|....:.|:....||.| .
  Fly   368 SALCIYSLKSIRRKFMQNIKSCF-------NGSGMRGLDFISPSMPCVLTKLQTIGEDFCGLD-V 424

Human   383 PSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSI 447
            .||:....|:.:.|:..: ..:||:||.|...|:|:.|:|.|.|.|.:|.:...|..:.|::.::
  Fly   425 NSPLGGETPITSVPVAMF-NTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAV 488

Human   448 QQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRS 512
            ..||.::||:.||....::|||:::.:.||.|..|:.:..|..||..||||||||.|..:||.||
  Fly   489 DLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRS 553

Human   513 EC-SRGQGPEQWLWSFQPELGCLQVAAMSPANISREETREVFLSVPDLPPLWPGESYSCHFGEHQ 576
            .| .....|..|: |::.. .|..:.::.|..:.|...|.:.|.:..||.|  .|:..|.| ..:
  Fly   554 NCQDDANDPLYWV-SYKTG-KCTTITSVVPHQLQRTTARTLELIIDHLPQL--KENLICAF-TTE 613

Human   577 SPALLTG-----SGVMCPSPDPSEAPVLPRGADY--VSVSVELRFGAVVIAKTSLSFYDCVAVTE 634
            ..||.|.     :||.|.:|.....|.:.:|..:  ..:||..|.|..::: |..:|:||
  Fly   614 DKALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVS-TDFTFFDC----- 672

Human   635 LRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPK 699
             ...:.|..||||.:.|:|||..|.|||
  Fly   673 -STHSSCTRCVSSEFPCDWCVEAHRCTH------------------------------------- 699

Human   700 ALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSP 764
                                   |.:......:|           ::.....|         ||.
  Fly   700 -----------------------DTAENCRNDIL-----------VTGVSRIG---------PSY 721

Human   765 QNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFP 829
            ::|||        |.|                                         |:.||
  Fly   722 RSGPG--------FCP-----------------------------------------TINAT--- 734

Human   830 GAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQ 894
                                                     |||....:.|
  Fly   735 -----------------------------------------GDGSEVLVAG-------------- 744

Human   895 YDTPGLWELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGL 959
                          |.|.         |..:.||:..:..:..|.:           |...:||.
  Fly   745 --------------GTSK---------SIKVKVHIIGQFIVQTRFV-----------CQFNIEGR 775

Human   960 EVVVEARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSV 1024
            ...:.|::    ..||   :.|...:..|.:..|.|.....:...|...:|:...:|||:|.|..
  Fly   776 VTSLNAQL----LGDT---IYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCRE 833

Human  1025 GHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQ-------CPAPLIHSVEPLTGPV 1082
            ....|..|.....:|.|.||.... .|...|.|.:.:...|.       ||.|.||:.:|.|||.
  Fly   834 MADSCGICLALSEKYNCGWCSSTN-TCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPW 897

Human  1083 DGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEV--AGATAVEV 1145
            :|||.:||||.|||::..|:...|.:||:.|....|.|..:..:||...:.||::  .|...|::
  Fly   898 EGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQI 962

Human  1146 PGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQ-PCHLLPE 1209
             |..||.|:.|:.:.|||:....|..||.:|||.:.:.|..|..|  ..|:..:.|. ||.:|..
  Fly   963 -GDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAG--SRIQASINDHLPCKILST 1024

Human  1210 QQSEQLRCETSPRPTPATLPVAVWFGATERRLQRG-----------QFKYTLDPNI--TSAGPT- 1260
            ..|:.: |.||..|           |..|.||:..           .|||.|||.:  .|:||:
  Fly  1025 DSSQAI-CRTSASP-----------GIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSG 1077

Human  1261 -----KSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSS 1320
                 |...:||..|.|.|.....:|.|.|.|..                             :.
  Fly  1078 QIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVY-----------------------------NG 1113

Human  1321 QQFEEPCHVNSSQLITCRTPAL-----------PGLPEDPWVRVEFILDNL--VFDFATLNPTPF 1372
            :.:..||.|.|...:.|.:|.:           |.|.|     ..|::||:  |.:.:.::...|
  Fly  1114 EMYASPCRVQSDTEMECASPVVDVDSHVIEAERPILLE-----YGFLMDNVLRVQNLSKVHNNHF 1173

Human  1373 SYEADPTLQPLNPEDPTMPFRHK--PGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHL 1435
            .      |.| |||......|.|  .....::.|.|||.|..:.:|...||:|.|.:.:|:|..|
  Fly  1174 E------LYP-NPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQL 1231

Human  1436 YCEPPVEQPLPRHHALREAPDSL--PEFTVQMG-NLRFSLGHVQYD--------GESPGAFPVAA 1489
            .|.||.|         ..|..|:  ||..|::| :|.:.:|.:.|:        ||:. .|.|.|
  Fly  1232 TCRPPSE---------ATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENV-IFAVIA 1286

Human  1490 QVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDL 1554
            .:      .:|.|..:.:::.|::||.::.|..:.:|.|::.||..|...||:.|.:|.||||||
  Fly  1287 TI------VILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDL 1345

Human  1555 TSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTV---EQGLGQLSNLLNSKLFL 1616
            |.||...|||||||:.||.:|.||.      |.|..|.:..||.:   |:||.....|:.:|.||
  Fly  1346 TGDLTSGGIPFLDYRSYAMKILFPN------HEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFL 1404

Human  1617 TKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYV--AKNPKLMLRRT 1679
            ..||.||||.|.||.|:|..||||:.|.|..||||.||||:|||.||:.:.:  ..:|||:||||
  Fly  1405 LLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRT 1469

Human  1680 ETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDV 1744
            |:|.||:|:.|.:..||.|:::..|||||||||.:|.||||||||:.|.:|:|:|::.:|:|:.:
  Fly  1470 ESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSI 1534

Human  1745 EYRPLTLNALLAVGP--------GAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPR 1801
            ::||:.:.|.:...|        .....:.|.|||||||||.|.|||.|:.:|:.:|.:|||...
  Fly  1535 DFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKD 1599

Human  1802 TLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKQVPDGATVALVPCLTK----HVLREN 1862
            .||:|||:|..|.:||.||||||:.:..|::||||||| .|||||.::|||..:.    .:|.:.
  Fly  1600 DLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHY-NVPDGAGLSLVPKQSSIYNFSILSDK 1663

Human  1863 QD------------YVPGERT------PMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGER 1909
            .:            |.....|      |:..|:.|.|:|.|||||..|.        ...:.|||
  Fly  1664 NEKSHKYETLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDS--------DMQKEGER 1720

Human  1910 ERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSR---PVPLAVKYFFDLLDEQAQQHGISDQ 1971
            .. |.:.||||||||:.||||||||||||:.|.||:.   .:|||:||.||.||:|||.|||:|.
  Fly  1721 VN-KLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDP 1784

Human  1972 DTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINK 2036
            :.:|.||:||||||||:|:||||.||||:..|:.:|:.|.|:||||||:|:.:||:||:|||.:|
  Fly  1785 EVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSK 1849

Human  2037 LLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYD 2101
            ||||:|||.|::.|:|||.|||...|.|||:||::|||.|..::.:.....||||||.|..||.:
  Fly  1850 LLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNE 1914

Human  2102 QIITALEEDGTAQKMQLGYRLQQI 2125
            |:...||||..:||.:|.::|:|:
  Fly  1915 QLTVTLEEDEFSQKQRLAFKLEQV 1938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLXNB1	XP_011532135.1	Sema_plexin_B1	28..480	CDD:200536	140/486 (29%)
		PSI	481..527	CDD:396154	20/46 (43%)
		TIG_plexin	541..627	CDD:465588	24/92 (26%)
		PSI	641..677	CDD:214655	13/35 (37%)
		PHA03247	<681..839	CDD:223021	13/157 (8%)
		TIG_2	921..1020	CDD:465619	19/98 (19%)
		PSI	1021..>1061	CDD:396154	10/39 (26%)
		IPT_plexin_repeat1	1070..1161	CDD:238585	35/92 (38%)
		IPT_plexin_repeat2	1162..1249	CDD:238584	27/98 (28%)
		IPT_plexin_repeat3	1252..1376	CDD:238586	28/144 (19%)
		Plexin_cytopl	1562..2098	CDD:462434	277/573 (48%)
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	139/483 (29%)
		PSI	522..574	CDD:396154	21/53 (40%)
		TIG_plexin	580..670	CDD:465588	24/93 (26%)
		PSI	671..>702	CDD:396154	16/96 (17%)
		TIG_2	738..829	CDD:465619	22/145 (15%)
		PSI	830..883	CDD:396154	11/53 (21%)
		IPT_plexin_repeat1	885..977	CDD:238585	35/92 (38%)
		IPT_plexin_repeat2	978..1063	CDD:238584	27/98 (28%)
		IPT	1078..1177	CDD:472823	25/138 (18%)
		TIG	<1196..>1246	CDD:460355	19/58 (33%)
		Plexin_cytopl	1353..1911	CDD:462434	277/573 (48%)