DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLXNB1 and PlexA

DIOPT Version :9

Sequence 1:XP_011532135.1 Gene:PLXNB1 / 5364 HGNCID:9103 Length:2136 Species:Homo sapiens
Sequence 2:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster


Alignment Length:2234 Identity:700/2234 - (31%)
Similarity:1036/2234 - (46%) Gaps:509/2234 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    33 TYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECP---QAQPT 94
            |.|.||..|..:|.:::|..|.|:||||.|:|..||.|||..||.:|  .::  :||   ...||
  Fly    73 TKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SIL--DCPLNAVRSPT 133

Human    95 NNPNQLLLV--SPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVA 157
            :|.|::||:  :...|:.|||:.||.|..|.|..:.  ::..|.|   ..|.|||...|||..:|
  Fly   134 DNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVS--IIEHEVP---DAVVANDANSSTVAFIA 193

Human   158 QGLAGEP---LLFVGRGYTSRG-VGGGIPPITTRALWPPDPQAAFSYEETA--KLAVGRLSEYSH 216
            .|....|   :::||..||:.. ....||.:.:|:|           |:|.  ::|...::..:.
  Fly   194 PGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL-----------EKTKMFQIASSAVTTGTR 247

Human   217 HFVSAFAR---------GAS----AYFLF--LRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPL 266
            .|::::||         |.|    :|||.  |:....:..:.:...:.|:|..|.:||||.|:|:
  Fly   248 TFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQEDSNYYSYTEIPV 312

Human   267 AC----EGG-RYGLIQAAAVA-TSREVAHG-------EVLFAAFSSAAPPTVGRPPSAAAGASGA 318
            .|    :|| ::.|:||..:. .|.::|..       :||||.||...    |..|      :..
  Fly   313 ECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGE----GNTP------TNN 367

Human   319 SALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEY-DVNSDCAQLPVDTLDAYPCGSDHT 382
            ||||.:.|..:.|...:...:|:       :|:.:..::: ..:..|....:.|:....||.| .
  Fly   368 SALCIYSLKSIRRKFMQNIKSCF-------NGSGMRGLDFISPSMPCVLTKLQTIGEDFCGLD-V 424

Human   383 PSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSI 447
            .||:....|:.:.|:..: ..:||:||.|...|:|:.|:|.|.|.|.:|.:...|..:.|::.::
  Fly   425 NSPLGGETPITSVPVAMF-NTKLTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAV 488

Human   448 QQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRS 512
            ..||.::||:.||....::|||:::.:.||.|..|:.:..|..||..||||||||.|..:||.||
  Fly   489 DLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRS 553

Human   513 EC-SRGQGPEQWLWSFQPELGCLQVAAMSPANISREETREVFLSVPDLPPLWPGESYSCHFGEHQ 576
            .| .....|..|: |::.. .|..:.::.|..:.|...|.:.|.:..||.|  .|:..|.| ..:
  Fly   554 NCQDDANDPLYWV-SYKTG-KCTTITSVVPHQLQRTTARTLELIIDHLPQL--KENLICAF-TTE 613

Human   577 SPALLTG-----SGVMCPSPDPSEAPVLPRGADY--VSVSVELRFGAVVIAKTSLSFYDCVAVTE 634
            ..||.|.     :||.|.:|.....|.:.:|..:  ..:||..|.|..::: |..:|:||     
  Fly   614 DKALFTNATKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVS-TDFTFFDC----- 672

Human   635 LRPSAQCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPK 699
             ...:.|..||||.:.|:|||..|.|||                                     
  Fly   673 -STHSSCTRCVSSEFPCDWCVEAHRCTH------------------------------------- 699

Human   700 ALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSP 764
                                   |.:......:|           ::.....|         ||.
  Fly   700 -----------------------DTAENCRNDIL-----------VTGVSRIG---------PSY 721

Human   765 QNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFP 829
            ::|||        |.|                                         |:.||   
  Fly   722 RSGPG--------FCP-----------------------------------------TINAT--- 734

Human   830 GAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQ 894
                                                     |||....:.|              
  Fly   735 -----------------------------------------GDGSEVLVAG-------------- 744

Human   895 YDTPGLWELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGL 959
                          |.|.         |..:.||:..:..:..|.:           |...:||.
  Fly   745 --------------GTSK---------SIKVKVHIIGQFIVQTRFV-----------CQFNIEGR 775

Human   960 EVVVEARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSV 1024
            ...:.|::    ..||   :.|...:..|.:..|.|.....:...|...:|:...:|||:|.|..
  Fly   776 VTSLNAQL----LGDT---IYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCRE 833

Human  1025 GHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQ-------CPAPLIHSVEPLTGPV 1082
            ....|..|.....:|.|.||.... .|...|.|.:.:...|.       ||.|.||:.:|.|||.
  Fly   834 MADSCGICLALSEKYNCGWCSSTN-TCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPW 897

Human  1083 DGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEV--AGATAVEV 1145
            :|||.:||||.|||::..|:...|.:||:.|....|.|..:..:||...:.||::  .|...|::
  Fly   898 EGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQI 962

Human  1146 PGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQ-PCHLLPE 1209
             |..||.|:.|:.:.|||:....|..||.:|||.:.:.|..|..|  ..|:..:.|. ||.:|..
  Fly   963 -GDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAG--SRIQASINDHLPCKILST 1024

Human  1210 QQSEQLRCETSPRPTPATLPVAVWFGATERRLQRG-----------QFKYTLDPNI--TSAGPT- 1260
            ..|:.: |.||..|           |..|.||:..           .|||.|||.:  .|:||: 
  Fly  1025 DSSQAI-CRTSASP-----------GIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSG 1077

Human  1261 -----KSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSS 1320
                 |...:||..|.|.|.....:|.|.|.|..                             :.
  Fly  1078 QIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVY-----------------------------NG 1113

Human  1321 QQFEEPCHVNSSQLITCRTPAL-----------PGLPEDPWVRVEFILDNL--VFDFATLNPTPF 1372
            :.:..||.|.|...:.|.:|.:           |.|.|     ..|::||:  |.:.:.::...|
  Fly  1114 EMYASPCRVQSDTEMECASPVVDVDSHVIEAERPILLE-----YGFLMDNVLRVQNLSKVHNNHF 1173

Human  1373 SYEADPTLQPLNPEDPTMPFRHK--PGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHL 1435
            .      |.| |||......|.|  .....::.|.|||.|..:.:|...||:|.|.:.:|:|..|
  Fly  1174 E------LYP-NPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNGFCNITSLSRQQL 1231

Human  1436 YCEPPVEQPLPRHHALREAPDSL--PEFTVQMG-NLRFSLGHVQYD--------GESPGAFPVAA 1489
            .|.||.|         ..|..|:  ||..|::| :|.:.:|.:.|:        ||:. .|.|.|
  Fly  1232 TCRPPSE---------ATATKSMNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENV-IFAVIA 1286

Human  1490 QVGLGVGTSLLALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDL 1554
            .:      .:|.|..:.:::.|::||.::.|..:.:|.|::.||..|...||:.|.:|.||||||
  Fly  1287 TI------VILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDL 1345

Human  1555 TSDLLGSGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTV---EQGLGQLSNLLNSKLFL 1616
            |.||...|||||||:.||.:|.||.      |.|..|.:..||.:   |:||.....|:.:|.||
  Fly  1346 TGDLTSGGIPFLDYRSYAMKILFPN------HEDHIVLQWERPELLRKEKGLRIFGQLIMNKTFL 1404

Human  1617 TKFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYV--AKNPKLMLRRT 1679
            ..||.||||.|.||.|:|..||||:.|.|..||||.||||:|||.||:.:.:  ..:|||:||||
  Fly  1405 LLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRT 1469

Human  1680 ETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDV 1744
            |:|.||:|:.|.:..||.|:::..|||||||||.:|.||||||||:.|.:|:|:|::.:|:|:.:
  Fly  1470 ESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSI 1534

Human  1745 EYRPLTLNALLAVGP--------GAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPR 1801
            ::||:.:.|.:...|        .....:.|.|||||||||.|.|||.|:.:|:.:|.:|||...
  Fly  1535 DFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKD 1599

Human  1802 TLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKQVPDGATVALVPCLTK----HVLREN 1862
            .||:|||:|..|.:||.||||||:.:..|::||||||| .|||||.::|||..:.    .:|.:.
  Fly  1600 DLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHY-NVPDGAGLSLVPKQSSIYNFSILSDK 1663

Human  1863 QD------------YVPGERT------PMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGER 1909
            .:            |.....|      |:..|:.|.|:|.|||||..|.        ...:.|||
  Fly  1664 NEKSHKYETLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDS--------DMQKEGER 1720

Human  1910 ERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSR---PVPLAVKYFFDLLDEQAQQHGISDQ 1971
            .. |.:.||||||||:.||||||||||||:.|.||:.   .:|||:||.||.||:|||.|||:|.
  Fly  1721 VN-KLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDP 1784

Human  1972 DTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINK 2036
            :.:|.||:||||||||:|:||||.||||:..|:.:|:.|.|:||||||:|:.:||:||:|||.:|
  Fly  1785 EVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSK 1849

Human  2037 LLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYD 2101
            ||||:|||.|::.|:|||.|||...|.|||:||::|||.|..::.:.....||||||.|..||.:
  Fly  1850 LLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNE 1914

Human  2102 QIITALEEDGTAQKMQLGYRLQQI 2125
            |:...||||..:||.:|.::|:|:
  Fly  1915 QLTVTLEEDEFSQKQRLAFKLEQV 1938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLXNB1XP_011532135.1 Sema_plexin_B1 28..480 CDD:200536 140/486 (29%)
PSI 481..527 CDD:307546 20/46 (43%)
PSI 641..677 CDD:214655 13/35 (37%)
Atrophin-1 <681..839 CDD:331285 13/157 (8%)
PSI 1021..1068 CDD:214655 11/53 (21%)
IPT_plexin_repeat1 1070..1161 CDD:238585 35/92 (38%)
IPT_plexin_repeat2 1162..1249 CDD:238584 27/98 (28%)
IPT_plexin_repeat3 1252..1376 CDD:238586 28/144 (19%)
Plexin_cytopl 1562..2103 CDD:311994 279/578 (48%)
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 139/483 (29%)
PSI 522..574 CDD:279745 21/53 (40%)
PSI 671..>699 CDD:279745 13/33 (39%)
PSI 830..883 CDD:279745 11/53 (21%)
IPT_plexin_repeat1 885..977 CDD:238585 35/92 (38%)
IPT_plexin_repeat2 978..1063 CDD:238584 27/98 (28%)
IPT 1078..1177 CDD:301692 25/138 (18%)
IPT_PCSR 1196..>1255 CDD:238337 22/67 (33%)
Plexin_cytopl 1353..1916 CDD:285529 279/578 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.820

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