DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S1PR5 and mAChR-C

DIOPT Version :9

Sequence 1:	NP_001159687.1	Gene:	S1PR5 / 53637	HGNCID:	14299	Length:	398	Species:	Homo sapiens
Sequence 2:	NP_572358.1	Gene:	mAChR-C / 31626	FlyBaseID:	FBgn0029909	Length:	371	Species:	Drosophila melanogaster

Alignment Length:	351	Identity:	89/351 - (25%)
Similarity:	147/351 - (41%)	Gaps:	73/351 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    33 GAGLRADAVVCLAVCAFIVLENLAVLLVLG------------RHPR-FHAPMFLLLGSLTLSDLL 84
            |||    .::.||:.||:      .:|:||            ||.| ..:.:|:|  ||.:||..
  Fly    47 GAG----HLLWLAINAFL------FVLILGGNILTIVAVRTCRHLRSVISNLFIL--SLAVSDFC 99

Human    85 AGAAYAANIL---------LSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMA-- 138
            .|.|...:::         :.||..|:     :|.    :..|...|:|:|::||::|.:.:.
  Fly   100 VGLALPYHLVFYMGSDIGAMRGPCLLR-----FFL----LICACCVSMLTLISIAVDRYIAVVYA 155

Human   139 ---RRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDAC--STVLPLYAKAYVLFCV 198
               ||    ..:|....::....|.:..|:.|||.. ||......||  ..||   |..|:...:
  Fly   156 LHYRR----YMTRRVAYSIIIFNWCLGALVALLPVF-WNRWPDAQACEFDEVL---APGYIAGVI 212

Human   199 L-AFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLAL---LRTLSVVLL- 258
            . .||.|...:..:|.||..:....|.||  |......|......  |:|.|   .:::.:|:.
  Fly   213 TPGFVIIWICMFLVYWRIMREASKQALRL--RQSVVYNTDEATTM--RNLLLHPDWKSVQIVVFI 273

Human   259 --AFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLV 321
              .|..||.|.|.:.:..:....::..::.:..  ..||:|||.||||||:..|...|.|.::.:
  Fly   274 MGCFTLCWLPYFCVAIAQLFSICQSSSMIYKTT--FSLAIANSALNPIIYSWKNSGFRRAFVQTL 336

Human   322 CC--GRHSCGRDPSGSQQSASAAEAS 345
            ||  .|....:.|:.|:....|..:|
  Fly   337 CCRTARQCEDQLPADSKHRMEATSSS 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S1PR5	NP_001159687.1	7tmA_S1PR5_Edg8	37..317	CDD:320470	78/315 (25%)
		TM helix 1	38..64	CDD:320470	7/37 (19%)
		TM helix 2	71..96	CDD:320470	8/33 (24%)
		TM helix 3	108..138	CDD:320470	8/29 (28%)
		TM helix 4	151..169	CDD:320470	3/17 (18%)
		TM helix 5	189..218	CDD:320470	8/29 (28%)
		TM helix 6	244..274	CDD:320470	9/35 (26%)
		TM helix 7	285..310	CDD:320470	11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..398		4/17 (24%)
mAChR-C	NP_572358.1	7tm_4	61..332	CDD:304433	74/295 (25%)
mAChR-C	NP_572358.1	7tm_1	67..321	CDD:278431	67/278 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910