DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S1PR5 and moody

DIOPT Version :9

Sequence 1:	NP_001159687.1	Gene:	S1PR5 / 53637	HGNCID:	14299	Length:	398	Species:	Homo sapiens
Sequence 2:	NP_001188534.1	Gene:	moody / 31168	FlyBaseID:	FBgn0025631	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	446	Identity:	98/446 - (21%)
Similarity:	161/446 - (36%)	Gaps:	130/446 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    35 GLRADAVVCLAVCAFIVL-----ENLAVLLVLGRHPRFH--APMFLLLGSLTLSDLL-------- 84
            |.....:...||..|:::     .||..::.|.:.|:..  |..|::  ||.::|||
  Fly    30 GFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAAAFII--SLCIADLLFCALVLPF 92

Human    85 AGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRG-PAPVSSR 148
            .|..:.......|.:..:|.|   |.:.|.:.|    |:|.:..|.:.|.:.:...| .|.:..|
  Fly    93 QGLRFVQGTWRHGQVLCRLIP---FIQYGNIGV----SLLCIAMITINRYVMITHHGLYARIYKR 150

Human   149 GRTLAMAAAAWGVSLLLGLLPALG-WNCLG---RLDACSTV---------LPLYAKAYVLFCVLA 200
            .....|.||.|..|..:.|...|| |...|   ||..||.:         ..|:..|:|:.|::
  Fly   151 HWIAVMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSIMTDDHGHSSKTTLFITAFVIPCLV- 214

Human   201 FVGILAAICALYARIYCQVRANARRL--------------------------------PARPGTA 233
                   |.|.||:|:..|..:.:||                                |:...::
  Fly   215 -------IIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGALPSGAECQPSNRVSS 272

Human   234 GTTST-----------------------RARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLD- 274
            .::|:                       ..|.|.....:.:.:..:.|:||.|:.|:.::.:.|
  Fly   273 DSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRITKMVLAIFLSFVVCYLPITIVKVADK 337

Human   275 -VACPA-RTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCC--GRHSCGRDPSGS 335
             |..|: ..|..:        |...::.:|||||.:.|:..|.|...:|.|  .|...   |.|.
  Fly   338 NVEHPSLHICSYI--------LLYLSACINPIIYVIMNKQYRKAYKTVVFCQPARLLL---PFGK 391

Human   336 QQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTG-SPGAPTAART 390
            ...||:|     ..:....||..:.|.:..|       ..||.|| :.||.||..|
  Fly   392 TNGASSA-----AEKWKDTGLSNNHSRTIVS-------QMSGGTGAASGAGTATGT 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S1PR5	NP_001159687.1	7tmA_S1PR5_Edg8	37..317	CDD:320470	75/366 (20%)
		TM helix 1	38..64	CDD:320470	6/30 (20%)
		TM helix 2	71..96	CDD:320470	7/32 (22%)
		TM helix 3	108..138	CDD:320470	7/29 (24%)
		TM helix 4	151..169	CDD:320470	6/17 (35%)
		TM helix 5	189..218	CDD:320470	8/28 (29%)
		TM helix 6	244..274	CDD:320470	5/29 (17%)
		TM helix 7	285..310	CDD:320470	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..398		18/63 (29%)
moody	NP_001188534.1	7tm_4	44..>167	CDD:304433	31/131 (24%)
		7tm_1	53..363	CDD:278431	68/334 (20%)
		7tm_4	<310..380	CDD:304433	19/77 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910