DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTOV1 and MED25

DIOPT Version :10

Sequence 1:NP_001351676.1 Gene:PTOV1 / 53635 HGNCID:9632 Length:431 Species:Homo sapiens
Sequence 2:NP_650854.1 Gene:MED25 / 42385 FlyBaseID:FBgn0038760 Length:863 Species:Drosophila melanogaster


Alignment Length:485 Identity:116/485 - (23%)
Similarity:189/485 - (38%) Gaps:146/485 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    27 GAPVPATPPE----------------------VVARASSQDSPAPERPAGPPSPH---------- 59
            |.|:..||.:                      :......|..|.|..|||..:|.          
  Fly   263 GMPMDTTPAQQQQQQQQQQQQQQQQGNPQQQVMNMNTMQQQQPGPNPPAGLLNPQQQQQLLQQQQ 327

Human    60 ----------------------------SAPARAPLPRAALEGARVFGALGPIGPSSPGLTLGGL 96
                                        :.|.:|..|  .::||   |.:|.:|..      ||:
  Fly   328 QNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQARPP--FMQGA---GNVGGVGQG------GGM 381

Human    97 AVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIP 161
               :...::.|::       :....|.:.:...|::....||...|.:..:..|..|:. ||::.
  Fly   382 ---QQNPNSALIS-------RINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQR-MQMLS 435

Human   162 QQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKK 226
            ||.:.....|.:..||||     :.....:|..:...|..||                       
  Fly   436 QQQMLNHQQLQQQQQLAQ-----QQQQQQQGQQQQQVNPNAG----------------------- 472

Human   227 KIFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNN---------------KFLAWS 276
               ..::|...:|.:|..:|    ::|.||.   .|.|.|..|.               :...|:
  Fly   473 ---NNMMPASNAGNMSNPQQ----QQQQVGQ---QSNPQQQGNPQQQQQGNSQQEQASLREKIWT 527

Human   277 GVMEWQEPRPEPNSRSKRWLPSHVYVN--QGE-ILRTEQWPRKLYMQLIPQQLLTTLVPLF-RNS 337
            ||:||.|.......:....|...|..|  .|| .::.|.||.||.|||:|:.|:..:...| ::|
  Fly   528 GVLEWSEKPKSDQQKIPHTLQCTVCTNIKDGEPEIKAENWPPKLLMQLMPKHLVGNIGGQFLKDS 592

Human   338 RLVQFHFTKDLETLKSLCRIMDNGFAGCVHFS---YKASCEIRVLMLLYSSEKKIFIGLIPHDQG 399
            ::|.|..|.. |.|.||.::|.:|:|||||||   ...:|:::||:|||:.::..|:|.||::|.
  Fly   593 KMVVFRPTPG-EALDSLAKMMTSGYAGCVHFSSIPNSPACDLKVLILLYTPDRNAFLGFIPNNQA 656

Human   400 NFVNGIRRVIANQQQVLQRNLEQEQQQRGM 429
            .||..:|:||   ||....|::|:|||:.|
  Fly   657 MFVERLRKVI---QQKQHGNMQQQQQQQQM 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTOV1NP_001351676.1 PRK12323 <1..156 CDD:481241 29/188 (15%)
Med25 104..253 CDD:463243 25/148 (17%)
Med25 269..414 CDD:463243 56/166 (34%)
MED25NP_650854.1 Med25_VWA 5..218 CDD:463253
Med25 520..671 CDD:463243 57/154 (37%)
Blue background indicates that the domain is not in the aligned region.

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