Protein Alignment PRKAG3 and aakg-1

DIOPT Version :10

• Sequence 1: NP_059127.2
• Gene: PRKAG3 / 53632
• HGNCID: 9387
• Length: 489
• Species: Homo sapiens
• Sequence 2: NP_001368643.1
• Gene: aakg-1 / 3565679
• WormBaseID: WBGene00013732
• Length: 801
• Species: Caenorhabditis elegans
• Alignment Length: 515
• Identity: 186/515 - (36%)
• Similarity: 281/515 - (54%)
• Gaps: 51/515 - (9%)

Human     4 GLEHALRRTP----------SWSSLGG--------SEHQEMSFLE---------------QENSS 35
            |...:|:|.|          |.||.||        |.|...|:..               |:::.
 Worm   226 GGSKSLKRPPDLNGSNNSGSSSSSSGGANSGVQQSSVHPSNSYSPRSRPLFVDTQMANHLQDSNM 290

Human    36 SWPSPAVTSSSERIRGKRRAKALRWTRQKSVEEGEPPGQGEGPRSRPAAESTGLEATFPKTTPLA 100
            ...|| |:...:.:||:.|..:|:.:       ..|....:...:|.:|...|.....|...|:.
 Worm   291 KRRSP-VSQVVDFVRGRNRTYSLQLS-------SSPMCSPQSVAARASASCDGCNGPPPPPQPIG 347

Human   101 QADPAGVGTPPTGWDCLPSDCTASAAGSSTDDVELATEFPATEAWECELEGLLEERPALCLSPQA 165
            .: |:|.....:|.....|........|....::|::......|...:...|.....::.:....
 Worm   348 MS-PSGRRQTISGRVHRASFTAGGTLKSFDSGLDLSSPTINHTALLIKEASLFSSFDSMSIGTAV 411

Human   166 P-FPKLGWDDELRKPGAQIYMRFMQEHTCYDAMATSSKLVIFDTMLEIKKAFFALVANGVRAAPL 229
            | ...:.:|:.     ..:|..||:.|.|||.:.||||||:|||.|.::|||:|||.||||||||
 Worm   412 PDINAIFFDNH-----DAVYSLFMKAHKCYDLIPTSSKLVVFDTHLPVRKAFYALVYNGVRAAPL 471

Human   230 WDSKKQSFVGMLTITDFILVLHRYY--RSPLVQIYEIEQHKIETWREIY-LQGCFKPLVSISPND 291
            ||:..|.|.|||||||||.:|.::|  .....:|..:|..:|..||:.: |.|..:|.|.|.||:
 Worm   472 WDTDNQRFTGMLTITDFIKILCKHYDKGDNSERIRALEDQQISHWRDQFELDGTLRPFVYIDPNE 536

Human   292 SLFEAVYTLIKNRIHRLPVLDPVSGNVLHILTHKRLLKFLHIFGSLLPRPSFLYRTIQDLGIGTF 356
            ||..||..|.::::|||||||..:||:.:||||||::|||.::...||||||:..|.::||||.:
 Worm   537 SLHRAVELLCESKVHRLPVLDRKTGNITYILTHKRIMKFLSLYMRDLPRPSFMSCTPRELGIGAW 601

Human   357 RDLAVVLETAPILTALDIFVDRRVSALPVVNECGQVVGLYSRFDVIHLAAQQTYNHLDMSVGEAL 421
            .|:.......||..||::|:..||||||:::|.|:||.:|::||||.|||:.:|:.||.:|.|||
 Worm   602 GDILCCHVDTPIHDALELFLKNRVSALPLIDENGRVVDIYAKFDVISLAAESSYDKLDCTVQEAL 666

Human   422 RQRTLCLEGVLSCQPHESLGEVIDRIAREQVHRLVLVDETQHLLGVVSLSDILQALVLSP 481
            :.|:...|||.:|...:||.:|::.|.:.:||||::.|:.:.::|||||||||:.|||.|
 Worm   667 QHRSEWFEGVQTCLETDSLFQVLEAIVKAEVHRLIVTDQDKKVVGVVSLSDILKNLVLDP 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAG3	NP_059127.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..113		28/141 (20%)
		CBS_euAMPK_gamma-like_repeat1	192..329	CDD:341388	74/139 (53%)
		CBS repeat	200..273	CDD:341388	41/74 (55%)
		CBS repeat	285..329	CDD:341388	24/43 (56%)
		AMPK pseudosubstrate	293..314		11/20 (55%)
		CBS_euAMPK_gamma-like_repeat2	355..478	CDD:341399	54/122 (44%)
		CBS repeat	356..421	CDD:341399	29/64 (45%)
		CBS repeat	432..475	CDD:341399	18/42 (43%)
aakg-1	NP_001368643.1	CBS_euAMPK_gamma-like_repeat1	434..574	CDD:341388	74/139 (53%)
		CBS repeat	442..517	CDD:341388	41/74 (55%)
		CBS repeat	530..574	CDD:341388	24/43 (56%)
		CBS_euAMPK_gamma-like_repeat2	601..723	CDD:341399	54/121 (45%)
		CBS repeat	601..666	CDD:341399	29/64 (45%)
		CBS repeat	677..720	CDD:341399	18/42 (43%)