Protein Alignment PRKAG3 and Prkag3

DIOPT Version :10

• Sequence 1: NP_059127.2
• Gene: PRKAG3 / 53632
• HGNCID: 9387
• Length: 489
• Species: Homo sapiens
• Sequence 2: NP_714966.1
• Gene: Prkag3 / 241113
• MGIID: 1891343
• Length: 489
• Species: Mus musculus
• Alignment Length: 490
• Identity: 415/490 - (84%)
• Similarity: 432/490 - (88%)
• Gaps: 2/490 - (0%)

Human     1 MEPGLEHALRRTPSWSSLGGSEHQEMSFLEQENSSSWPSPAVTSSSERIRGKRRAKALRWTRQKS 65
            |||.|||.|..|.:||..||.|.|||.|||| ..:|||||||.:||||....|..||.|||||::
Mouse     1 MEPELEHTLPGTLTWSHSGGPESQEMDFLEQ-GENSWPSPAVATSSERTCAIRGVKASRWTRQEA 64

Human    66 VEEGEPPGQGEGPRSRPAAESTGLEATFPKTTPLAQADP-AGVGTPPTGWDCLPSDCTASAAGSS 129
            |||.||||.|||.:||||||||..||||||.||||||.| |...|.|||||.|..||.|||.|||
Mouse    65 VEEAEPPGLGEGAQSRPAAESTRQEATFPKATPLAQAVPLAEAETSPTGWDLLLPDCAASAGGSS 129

Human   130 TDDVELATEFPATEAWECELEGLLEERPALCLSPQAPFPKLGWDDELRKPGAQIYMRFMQEHTCY 194
            |.|:||..||||.|||:||||||.::||....|||||...|.|||||:|||||:||.||||||||
Mouse   130 TGDLELTIEFPAPEAWDCELEGLGKDRPRPGPSPQAPLLGLSWDDELQKPGAQVYMHFMQEHTCY 194

Human   195 DAMATSSKLVIFDTMLEIKKAFFALVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLV 259
            ||||||||||||||.|||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   195 DAMATSSKLVIFDTTLEIKKAFFAMVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLV 259

Human   260 QIYEIEQHKIETWREIYLQGCFKPLVSISPNDSLFEAVYTLIKNRIHRLPVLDPVSGNVLHILTH 324
            ||||||:||||||||||||||||||||||||||||||||.|||||||||||||||||.||:||||
Mouse   260 QIYEIEEHKIETWREIYLQGCFKPLVSISPNDSLFEAVYALIKNRIHRLPVLDPVSGTVLYILTH 324

Human   325 KRLLKFLHIFGSLLPRPSFLYRTIQDLGIGTFRDLAVVLETAPILTALDIFVDRRVSALPVVNEC 389
            |||||||||||:||||||||.||||||||||||||||||||||:||||||||||||||||||||.
Mouse   325 KRLLKFLHIFGALLPRPSFLCRTIQDLGIGTFRDLAVVLETAPVLTALDIFVDRRVSALPVVNES 389

Human   390 GQVVGLYSRFDVIHLAAQQTYNHLDMSVGEALRQRTLCLEGVLSCQPHESLGEVIDRIAREQVHR 454
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   390 GQVVGLYSRFDVIHLAAQQTYNHLDMSVGEALRQRTLCLEGVLSCQPHESLGEVIDRIAREQVHR 454

Human   455 LVLVDETQHLLGVVSLSDILQALVLSPAGIDALGA 489
            |||||||||||||||||||||||||||||||||.|
Mouse   455 LVLVDETQHLLGVVSLSDILQALVLSPAGIDALSA 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAG3	NP_059127.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..113		73/112 (65%)
		CBS_euAMPK_gamma-like_repeat1	192..329	CDD:341388	130/136 (96%)
		CBS repeat	200..273	CDD:341388	69/72 (96%)
		CBS repeat	285..329	CDD:341388	40/43 (93%)
		AMPK pseudosubstrate	293..314		19/20 (95%)
		CBS_euAMPK_gamma-like_repeat2	355..478	CDD:341399	120/122 (98%)
		CBS repeat	356..421	CDD:341399	62/64 (97%)
		CBS repeat	432..475	CDD:341399	42/42 (100%)
Prkag3	NP_714966.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..95		62/94 (66%)
		CBS_euAMPK_gamma-like_repeat1	192..329	CDD:341388	130/136 (96%)
		CBS repeat	200..273	CDD:341388	69/72 (96%)
		CBS repeat	285..329	CDD:341388	40/43 (93%)
		AMPK pseudosubstrate	293..314		19/20 (95%)
		CBS_euAMPK_gamma-like_repeat2	355..478	CDD:341399	120/122 (98%)
		CBS repeat	356..421	CDD:341399	62/64 (97%)
		CBS repeat	432..475	CDD:341399	42/42 (100%)