DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLXNA2 and PlexA

DIOPT Version :9

Sequence 1:XP_005273221.1 Gene:PLXNA2 / 5362 HGNCID:9100 Length:1974 Species:Homo sapiens
Sequence 2:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster


Alignment Length:2034 Identity:813/2034 - (39%)
Similarity:1148/2034 - (56%) Gaps:282/2034 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    62 DWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTN 126
            |...|||.|...||.|:||.:||:|:|:.:|.:....||||:.|:..|  .::..|.:.|.:.|:
  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVEC--SILDCPLNAVRSPTD 134

Human   127 NVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSE 191
            |.||:|:||.:.:||:|||||:||.|.:..|.::.|:       ||.:..         .:|.::
  Fly   135 NYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPD---------AVVAND 183

Human   192 GEDGK----------------LFIGTAVDGKQDY---FPTLSSRKLPRDPESSAMLDYELHSDFV 237
            .....                :::|........|   .|.::||.|    |.:.|  :::.|..|
  Fly   184 ANSSTVAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKM--FQIASSAV 242

Human   238 SSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQ-----PETPEGVAINSAGDLFYTSRIVR 297
            ::..:...::.|..::| :.|:|||:|..|.||||.|     ..:|:.          |.:::||
  Fly   243 TTGTRTFINSYARETYF-VNYVYGFSSERFSYFLTTQLKHSHHSSPKE----------YITKLVR 296

Human   298 LCKDDPKFHSYVSLPFGC---TRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQK 359
            :|::|..::||..:|..|   .:.|.::.|:||.:|.||...|||:..|:.|||||||:||||:.
  Fly   297 ICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEG 361

Human   360 QYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQC--TKAPVPIDDNFCGL 422
              :.|.::||||.:.:::|..:..:.::||:.|.|...|:: :...:.|  ||... |.::||||
  Fly   362 --NTPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQT-IGEDFCGL 422

Human   423 DINQPLGGSTPVEG--LTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQY 485
            |:|.||||.||:..  :.::.|   ::||||:...:||:||||||..|.|||:..:.   ..:..
  Fly   423 DVNSPLGGETPITSVPVAMFNT---KLTSVAATSTSGYTVVFVGTSDGFLKKVVIES---SSIAN 481

Human   486 EMVSVLKD-GSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALH 549
            |..|...| ||.|.|||.|.....|:||||:.:|::|.|..|..|.|||:||.:.||:||||:|.
  Fly   482 EYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLE 546

Human   550 NMCSRRDKCQ-QAWEPNRFAA-SISQCVSLAVHPSSISVSEH------SRLLSLVVSDAPDLSAG 606
            |.||.|..|| .|.:|..:.: ...:|.::.      ||..|      :|.|.|::...|.|...
  Fly   547 NKCSPRSNCQDDANDPLYWVSYKTGKCTTIT------SVVPHQLQRTTARTLELIIDHLPQLKEN 605

Human   607 IACA--------FGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVS 663
            :.||        |.|.|:....|:     |.:|....:|.|...:..|..:|.:|:: .|...||
  Fly   606 LICAFTTEDKALFTNATKKRNGVN-----CTTPRTDMLPQIEQGKHHFTAKLSVRTR-NGPDLVS 664

Human   664 TEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPT-TC--------------SFQEGRINIS 713
            |:|.|::||.|..|..||:|.|.|.||...:.||||.. .|              |::.|    .
  Fly   665 TDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----P 725

Human   714 EDCPQLVPT---EEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSV 775
            ..||.:..|   .|:|:..|..|.|.:|...:.| ...|..:.|..||:|.:..:.| :....::
  Fly   726 GFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTI 788

Human   776 QCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGW 840
            .|.:..:||.... .||...|||:|.|:..:|||.::.|.:|:|....:|||:||....|:.|||
  Fly   789 YCDSMEFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGW 852

Human   841 CSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEI 905
            ||....|.:.:.|........||.:.:..|.||:|......:||.||||.:||.|:|||.::::|
  Fly   853 CSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDI 917

Human   906 AHHVQVAGVPCTPLPGEYIIAEQIVCEM---GHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFV 967
            ...|::||:.|.|.|..||..:||||.:   |..:.  .:|.:.:.||:.:.|    |.:.|.||
  Fly   918 YSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMY--RNGKIVVQIGDYRGE----SKEDYEFV 976

Human   968 NPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQ-TCEFYGRSMSEIVCVSPPSSNGLG 1031
            :|.:|..||..||.||||.:.|||.:|.|||.:...:.:. .|:......|:.:| ...:|.|:.
  Fly   977 DPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAIC-RTSASPGII 1040

Human  1032 PVPVSVSVDRAHVDSN-LQFEYIDDPRVQRIE---------PEWSIASGHTPLTITGFNLDVIQE 1086
            ...:.:|.|....:.| ..|:|:.||.|:.:.         |: .|.:|...:::||.....||.
  Fly  1041 EGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK-GIPAGGIRISVTGTQFTSIQN 1104

Human  1087 PRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPD--EFGFVFNN---VQSLLI 1146
            |.|.|.:||:...:.|:|.:.|.:.|.:|.:..|..  :...|||.  |:||:.:|   ||:|..
  Fly  1105 PNIYVVYNGEMYASPCRVQSDTEMECASPVVDVDSH--VIEAERPILLEYGFLMDNVLRVQNLSK 1167

Human  1147 YNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNL---CPPASGGAKLNYTVLIGETPCAVT 1208
            .::..|..||||.:.:....  :.......:.:.|:||   |..:      :..|.||...|.:|
  Fly  1168 VHNNHFELYPNPEYFIFEER--VKYFKSEYLTINGRNLDRACKES------DVEVKIGNGFCNIT 1224

Human  1209 -VSETQLLCEPP-------NLTGQHKVMVHVG-GMVFSPGSVSVISDSLLT---LPAIVSIAAGG 1261
             :|..||.|.||       ::.|. :|:|.:| .:.:..|.:|..|.:::.   ...|.::.|..
  Fly  1225 SLSRQQLTCRPPSEATATKSMNGP-EVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATI 1288

Human  1262 SLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSG 1326
            .:||:|.:.:|:|||:||.|:...|:.:|.|||.||.|||.|||||||||||::.:||.||...|
  Fly  1289 VILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGG 1353

Human  1327 IPYLDYRTYAMRVLFPGIEDHPVLR----ELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTL 1387
            ||:||||:|||::|||..|||.||:    ||       ...||.|::|.|||.||.|||.|||||
  Fly  1354 IPFLDYRSYAMKILFPNHEDHIVLQWERPEL-------LRKEKGLRIFGQLIMNKTFLLLFIRTL 1411

Human  1388 ELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKM 1452
            |..|.||||:|.|||||||..||.:|||.||:||.||.|||:|.:|.|:||||||||||||||||
  Fly  1412 ESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKM 1476

Human  1453 LTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIE------ 1511
            |:.||.|||:|||||||||||:||:.|:|.|::|||:||.|.||||||||:|||||.|:      
  Fly  1477 LSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNV 1541

Human  1512 YKTLI---LNCVNPD--NENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWR 1571
            |.::|   :.|.|.|  ..::..:.||||:||||.|||||.|:.:|:|:|.|||||..|:|||||
  Fly  1542 YASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWR 1606

Human  1572 QGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNI-------PASASIS 1629
            .|...||:|.|||:|:|.|.:||:||||.||.|.|.:.::|||||:|.||.       ..|....
  Fly  1607 TGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYE 1671

Human  1630 RTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLT 1694
            ..:||:|.||     ||...|:.:|:.....|:|::.|||||:||...||||:|.:|:|||||||
  Fly  1672 TLNISKYTSS-----SPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLT 1731

Human  1695 RLLATKTLLVLLCSCQEAPSPPACSSDTVSGLACSLCPLIHPWEARTRGTSCLPVKDPEPTPCVE 1759
            ||||||                                                           
  Fly  1732 RLLATK----------------------------------------------------------- 1737

Human  1760 CGMWLQGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLP 1824
                  |||||||||||||:|||.||||||||||||||||||:||..|.|.|.:|.||||||.||
  Fly  1738 ------GTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLP 1796

Human  1825 LRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKS 1889
            ||||||:||||.|||||||.:|.|:||||||||||||||||:|||||||||:|||||||||.|:.
  Fly  1797 LRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRK 1861

Human  1890 WVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQA 1954
            ||:|||.||..:..||||||||.|||:||||..|||...||:|:|:|..||:|:|...||:||.:
  Fly  1862 WVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFS 1926

Human  1955 RRQRLAYKVEQLINAMSIE 1973
            ::||||:|:||:.|.||.|
  Fly  1927 QKQRLAFKLEQVHNIMSSE 1945

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLXNA2XP_005273221.1 Sema_plexin_A2 53..567 CDD:200533 184/537 (34%)
PSI 670..717 CDD:279745 18/61 (30%)
PSI 821..870 CDD:279745 15/48 (31%)
IPT_plexin_repeat1 873..968 CDD:238585 35/97 (36%)
IPT_plexin_repeat2 969..1052 CDD:238584 26/84 (31%)
IPT_plexin_repeat3 1056..1156 CDD:238586 31/113 (27%)
TIG 1158..1242 CDD:280079 21/95 (22%)
Plexin_cytopl 1326..1944 CDD:285529 360/639 (56%)
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 160/489 (33%)
PSI 522..574 CDD:279745 22/51 (43%)
PSI 671..>699 CDD:279745 12/27 (44%)
PSI 830..883 CDD:279745 16/52 (31%)
IPT_plexin_repeat1 885..977 CDD:238585 35/97 (36%)
IPT_plexin_repeat2 978..1063 CDD:238584 26/85 (31%)
IPT 1078..1177 CDD:301692 29/101 (29%)
IPT_PCSR 1196..>1255 CDD:238337 18/65 (28%)
Plexin_cytopl 1353..1916 CDD:285529 360/639 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 709 1.000 Domainoid score I119
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H56427
Inparanoid 1 1.050 1366 1.000 Inparanoid score I130
Isobase 1 0.950 - 0 Normalized mean entropy S4424
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 1 1.000 - - otm41887
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3977
SonicParanoid 1 1.000 - - X591
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.810

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