DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhap-at and gnpat

DIOPT Version :9

Sequence 1:	NP_001262957.1	Gene:	Dhap-at / 53586	FlyBaseID:	FBgn0040212	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001073039.1	Gene:	gnpat / 733943	XenbaseID:	XB-GENE-948374	Length:	668	Species:	Xenopus tropicalis

Alignment Length:	713	Identity:	216/713 - (30%)
Similarity:	352/713 - (49%)	Gaps:	66/713 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 STSSGTVEGESSEQEEQKTPSAAEYMRNFKNIIAPGNEASMTRE----FNPQVAYEFEKYLNPQK 69
            :.|.|:|..:...:.:::        ..|::|:....::|..|.    :.| |.|.......|..
Frog     2 AASMGSVYSQKEFRSKKR--------EVFEDILEERRQSSDLRYAMKCYTP-VIYRNLTPCTPSG 57

  Fly    70 LKQHVLRSEKLRSILEHYAKESGTPLKQMERQARAIIDEIGLDRNMAIIRWCGIAITAIGKRICD 134
            ||..||:|.:|:.::...:.|||...:.::.||..|:||:|.:..|..||...::::.|.||:..
Frog    58 LKTSVLQSLELQYVIRQISSESGESCESIQEQAAEILDEMGHNLRMGAIRLFAMSLSKIFKRLFQ 122

  Fly   135 GFYVNSASMANVRKDMGKCPVLYLPSHRSYMDFILMSYICYYYDIEIPGIAAGMDFHSMFGMGTM 199
            ...||...:..:.:.:.:.||:.|||||||:||::|||:.|.||:.:|.|||||||..|..:|.:
Frog   123 KVCVNEEGIQRLTQAIQEHPVVLLPSHRSYIDFLMMSYVLYSYDLALPVIAAGMDFMGMKIVGEL 187

  Fly   200 LRKTGAFFMRRSFSNDELYWDIFREYMYALVANYHIGVEFFIEGTRSRNFKALVPKIGLLSMALL 264
            ||.:|||:|||||..::|||.:|.||:..|:.|.:..||||:||.|||..|.|.||.|||::|:.
Frog   188 LRMSGAFYMRRSFRGNQLYWAVFAEYVKTLIRNGYAPVEFFVEGQRSRTCKTLSPKFGLLNIAME 252

  Fly   265 PYFTGEVPDVMIVPVSVAYERVLEEQLFVYELLGVPKPKESTKGFFKALKIIDERFGKMFLDFGE 329
            |:|.|||.|..|||:|:.|||||||.|:.|||||||||||||.|..||.:|::|.||.:.:.||:
Frog   253 PFFKGEVFDTYIVPISINYERVLEESLYAYELLGVPKPKESTSGLIKARRILNENFGSIHIYFGQ 317

  Fly   330 PISVKEFFGHDSAQRMQRAGVGGHLQKLNRQEVE-LVKQLANEIIYQQQRRIVISTFNLLSLYYA 393
            |||::. .......|.|......||.:...::|: .|:.:|.::...|...:|:|...|::....
Frog   318 PISLRS-LASGIINRTQYNLKPRHLPQRPPEDVQSFVRDVAYQVELNQIANMVLSPGVLVATILL 381

  Fly   394 SQLYAQRSVTLDELARGVLHLKRIFEQLGAHVSTTPSSIKAD--VIDAVEIHSNILHFATGRLQF 456
            ..|   ..:..:.|....|.||.:.|..|..:. .|.::.|.  |..::::||||.....|.:
Frog   382 QNL---PGMDFNVLVEKTLWLKDLIEAFGGFLE-WPDNLSASRVVRSSIDLHSNIFTLVDGHV-- 440

  Fly   457 TPMAAKQ---LAEQIDVKRLKAHALCPQTMAVAVPMLALQLYINPCMFWLARPAYLLLAALKEQK 518
            |.:..|.   |.|:|..::             ||.:|....|.|..:....|||.::||....|.
Frog   441 TLLEHKHTGLLTEEIVFEQ-------------AVSLLMCAFYRNQMINVCVRPALVVLACEMVQS 492

  Fly   519 NQQKQSTDISYDASLCALHAHVTTMDALFQHEFIIESNREAAEFETHLQLLLDERVVEVETSGRI 583
            :.:::            :....:.:.::|..|||.....|..:|:....:|....::.. |...|
Frog   493 SIKEE------------IFRSFSFLRSVFSKEFIFFPGSEDKDFDEGCFMLTKCDIIHT-TPSEI 544

  Fly   584 NVQDNE--CSHVILAALAPFLCLYYQLVVTLRKIPLELEFSNKELLVRVQQHVEQLLQQPGASAS 646
            .:.|..  .:..:.....||| ..|:|..|.....:...|:.|:.:..|:..:.:|:.. |.|..
Frog   545 MITDKGTIAAFFLSKMFQPFL-EGYKLAYTYLVGEVTNAFTEKQYISGVRSFISRLIVS-GTSKC 607

  Fly   647 HVHPYCLALDNLNIAIYALIQRGYLVKSRDSGQMKIASTPGKCL-RELETQLLEYCQLMPFAQ 708
            :   ..|:.|.....:.:.:|.|.|.:      ||..|....|| :::..:..|...|..|.:
Frog   608 Y---EALSSDMQKNILSSFVQLGVLKR------MKSVSEATFCLEKKMVKETAEKLGLQMFTE 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhap-at	NP_001262957.1	LPLAT_DHAPAT-like	133..338	CDD:153255	107/204 (52%)
gnpat	NP_001073039.1	PTZ00374	<54..513	CDD:240389	172/490 (35%)
gnpat	NP_001073039.1	LPLAT_DHAPAT-like	121..324	CDD:153255	107/203 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4179
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40716
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2835
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	1	1.000	-	-		FOG0003976
OrthoInspector	1	1.000	-	-		otm49542
Panther	1	1.100	-	-	LDO	PTHR12563
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2733
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160