Protein Alignment Gnpat and GPAM

DIOPT Version :10

• Sequence 1: NP_001262957.1
• Gene: Gnpat / 53586
• FlyBaseID: FBgn0040212
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_065969.3
• Gene: GPAM / 57678
• HGNCID: 24865
• Length: 828
• Species: Homo sapiens
• Alignment Length: 812
• Identity: 171/812 - (21%)
• Similarity: 307/812 - (37%)
• Gaps: 230/812 - (28%)

  Fly    21 EQEEQKTPSAAEYMRNFKNIIAPGNEASMTREFNPQVAYEFEKYLNPQKLKQHVLRSEKLRSILE 85
            |::..|...|.....|..|       :|..:|...:||.|    |||                 :
Human   117 ERDVHKGMFATNVTENVLN-------SSRVQEAIAEVAAE----LNP-----------------D 153

  Fly    86 HYAKESGTPLKQMERQARAIIDEIGLDRNMAIIRWCGIAITAIGKRICDGFY------------V 138
            ..|::....:.:::::|:.|:.|:....:.|:||..|..:.    ::.:.|:            |
Human   154 GSAQQQSKAVNKVKKKAKRILQEMVATVSPAMIRLTGWVLL----KLFNSFFWNIQIHKGQLEMV 214

  Fly   139 NSASMANVRKDMGKCPVLYLPSHRSYMDFILMSYICYYYDIEIPGIAAGMDFHSMFGMGTMLRKT 203
            .:|:..|:       |:|:||.|||::|::|:::|.:.::|:.|.||:|.:.:... ..|::.|.
Human   215 KAATETNL-------PLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPI-FSTLIHKL 271

  Fly   204 GAFFMRRSFS------NDELYWDIFREYMYALVANYHIGVEFFIEGTRSRNFKALVPKIGLLSMA 262
            |.||:||...      .|.||..:...::..|:..... :|.|:||||||:.|....:.||||:.
Human   272 GGFFIRRRLDETPDGRKDVLYRALLHGHIVELLRQQQF-LEIFLEGTRSRSGKTSCARAGLLSVV 335

  Fly   263 LLPYFTGEVPDVMIVPVSVAYERVLEEQLFVYELLGVPKPKES----TKGFFKALKIIDERFGKM 323
            :....|..:||::|:||.::|:|::|.. :..|.||.||..||    .:|..:.|:   :.:|.:
Human   336 VDTLSTNVIPDILIIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARGVIRMLR---KNYGCV 396

  Fly   324 FLDFGEPISVKEFF---------------------------------GHDSAQRMQRAGVGGHLQ 355
            .:||.:|.|:||:.                                 |.|::....|......|:
Human   397 RVDFAQPFSLKEYLESQSQKPVSALLSLEQALLPAILPSRPSDAADEGRDTSINESRNATDESLR 461

  Fly   356 KLNRQEVELVKQLANEIIYQQQRRIVISTFNLLS--LYYASQLYAQRSVTLDE--------LARG 410
            :      .|:..||..|::...:...|.:.::::  |.|..:.....|..:::        |||.
Human   462 R------RLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARD 520

  Fly   411 ------------VLHLKRIFEQLG-----AHVS------TTPSSIKADVIDAVEIHSN-ILHF-- 449
                        |:|   ..:.||     .|.|      .|||:....|.: :..:|| :||.
Human   521 FDLGFSGNSEDVVMH---AIQLLGNCVTITHTSRNDEFFITPSTTVPSVFE-LNFYSNGVLHVFI 581

  Fly   450 ----------------ATGRLQFTPMAAKQLAEQIDVKRLKAHALCPQTMAVAVPMLALQLYINP 498
                            ..|....||   ..|..|..:.| ||.:||..........|..|.:...
Human   582 MEAIIACSLYAVLNKRGLGGPTSTP---PNLISQEQLVR-KAASLCYLLSNEGTISLPCQTFYQV 642

  Fly   499 CMFWLARPAYLLLAALKEQKNQQKQSTDIS---YDASL---CALHAHVTTMDALFQHE-----FI 552
            |...:.:.....:..:.|..:|:..|..::   :|..|   .:..:.....|:.|..|     ..
Human   643 CHETVGKFIQYGILTVAEHDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLK 707

  Fly   553 IESNREAAEFETHLQLLLDERVVEVETSGRINVQDNECSHVILAALAPFLCLYYQLVVTLRKIPL 617
            :..::|..:|.|.||.||.. ::|..:|..|.|.:
Human   708 VSQSKEHQQFITFLQRLLGP-LLEAYSSAAIFVHN------------------------------ 741

  Fly   618 ELEFSNKELLVRVQQHVEQLLQQPGASASHVHPYCLALDNLNIAIYALIQRGYLVKS-----RDS 677
               ||..   |...:::::|           |.|.:.....|:|:||......|||:     :|.
Human   742 ---FSGP---VPEPEYLQKL-----------HKYLITRTERNVAVYAESATYCLVKNAVKMFKDI 789

  Fly   678 GQMKIASTPGKCLRELETQLLEYCQLMPFAQY 709
            |..|........:.||.:..|..|......:|
Human   790 GVFKETKQKRVSVLELSSTFLPQCNRQKLLEY 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gnpat	NP_001262957.1	PlsB	63..684	CDD:442180	156/743 (21%)
		LPLAT_DHAPAT-like	133..338	CDD:153255	68/259 (26%)
GPAM	NP_065969.3	Important for mitochondrial localization	80..120		1/2 (50%)
		PlsB	105..656	CDD:442180	131/597 (22%)
		LPLAT_DHAPAT-like	201..411	CDD:153255	67/222 (30%)
		HXXXXD motif. /evidence=ECO:0000269|PubMed:36522428	230..235		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	435..455		3/19 (16%)