DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhap-at and gnpat

DIOPT Version :9

Sequence 1:	NP_001262957.1	Gene:	Dhap-at / 53586	FlyBaseID:	FBgn0040212	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_002665694.2	Gene:	gnpat / 572335	ZFINID:	ZDB-GENE-040618-4	Length:	668	Species:	Danio rerio

Alignment Length:	582	Identity:	188/582 - (32%)
Similarity:	300/582 - (51%)	Gaps:	33/582 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KYLNPQK---LKQHVLRSEKLRSILEHYAKESGTPLKQMERQARAIIDEIGLDRNMAIIRWCGIA 124
            |.|.|.|   ||..||:|:.|:.:::..:.|||...:.:..:|..|:||:.....::.||:....
Zfish    46 KGLVPCKASVLKTIVLQSDHLQYVIKQVSSESGDSPECVTEEASLILDEMAHRLQLSTIRFFAFT 110

  Fly   125 ITAIGKRICDGFYVNSASMANVRKDMGKCPVLYLPSHRSYMDFILMSYICYYYDIEIPGIAAGMD 189
            ::...|.:.....||...:..:::.:.:.||:.||||||||||::||||.|.||:.:|.||||||
Zfish   111 LSKAFKCLFRSVCVNEEGIQRLQQAVQEHPVVLLPSHRSYMDFLMMSYILYTYDLPLPVIAAGMD 175

  Fly   190 FHSMFGMGTMLRKTGAFFMRRSFSNDELYWDIFREYMYALVANYHIGVEFFIEGTRSRNFKALVP 254
            |.||..:|.|||.:||||:||||..|:|||.:|.||:..::.|.:..:|||:||||||..|:|.|
Zfish   176 FMSMKFVGEMLRMSGAFFIRRSFGGDKLYWAVFSEYVKTMLRNGYAPIEFFLEGTRSRTCKSLTP 240

  Fly   255 KIGLLSMALLPYFTGEVPDVMIVPVSVAYERVLEEQLFVYELLGVPKPKESTKGFFKALKIIDER 319
            |.|||::.:.|:|.||:.||.:||||::|||:|||.|:..||||||||||||.|..||.:::.|.
Zfish   241 KTGLLNIVMEPFFKGELFDVNLVPVSISYERILEESLYARELLGVPKPKESTSGLLKARRVLSED 305

  Fly   320 FGKMFLDFGEPISVKEFFGHDSAQRMQRAGVGGHL-QKLNRQEVELVKQLANEIIYQQQRRIVIS 383
            :|.|.:.||:|:||:. .......|.|...:..|: ||.:....|.:......::..|:..:|:.
Zfish   306 YGSMHVYFGQPVSVRS-LAERKINRSQYNLLPRHIPQKPSTDTHEFLTDAGFRLVRMQEENMVLK 369

  Fly   384 TFNLLSLYYASQLYAQRSVTLDELARGVLHLKRIFEQLGAHVSTTPSSIKADVI-DAVEIHSNIL 447
            .:.|::...   |:....:.|..|......|:.:....||.:.........:|| .::.:|.::|
Zfish   370 PWVLIATLL---LHNPDGLDLSSLTEQTDWLRHLALAFGAFLDWPDHESCTEVIRSSLALHRHLL 431

  Fly   448 HFATGRLQFTPMAAKQLAEQIDVKRLKAHALCPQTMAVAVPMLALQLYINPCMFWLARPAYLLLA 512
            ..:.|.:|.:...:.|:  |:..:....|.        ||.:|:...|.|..:....|||  |||
Zfish   432 SISAGHVQLSATDSPQV--QMSAEEAVFHR--------AVVVLSCASYRNQILHVFLRPA--LLA 484

  Fly   513 ALKEQKNQQKQSTDISYDASLCALHAHVTTMDALFQHEFIIESNREAAEFETHLQLLLDERVVEV 577
            ...:..|..::.     |...|     .:.:..:|.:|||:.......:||....||:...|::|
Zfish   485 VAMQSANSSRKD-----DIYNC-----FSFLRNMFSNEFILCPGDSVQDFEEACYLLMKRGVLQV 539

  Fly   578 ETSGRINVQDNECSHVIL-AALAPFLCLYYQLVVTLRKIPLELEFSNKELLVRVQQHVEQLL 638
            .....:...|...:...| ..|.||| ..||:|............:.||.:..|:....:|:
Zfish   540 LEHEIVMSADGHSTLAFLCTVLDPFL-QGYQVVCRYLCEETNENLTEKEFIPGVRDFALKLI 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhap-at	NP_001262957.1	LPLAT_DHAPAT-like	133..338	CDD:153255	107/204 (52%)
gnpat	XP_002665694.2	LPLAT_DHAPAT-like	119..324	CDD:153255	107/205 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595713
Domainoid	1	1.000	161	1.000	Domainoid score	I3978
eggNOG	1	0.900	-	-		E1_COG2937
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40716
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2931
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	1	1.000	-	-		FOG0003976
OrthoInspector	1	1.000	-	-		otm26270
orthoMCL	1	0.900	-	-		OOG6_103425
Panther	1	1.100	-	-	LDO	PTHR12563
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3282
SonicParanoid	1	1.000	-	-		X2733
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790