DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhap-at and gpat2

DIOPT Version :9

Sequence 1:	NP_001262957.1	Gene:	Dhap-at / 53586	FlyBaseID:	FBgn0040212	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001082849.1	Gene:	gpat2 / 558437	ZFINID:	ZDB-GENE-050309-118	Length:	787	Species:	Danio rerio

Alignment Length:	771	Identity:	146/771 - (18%)
Similarity:	270/771 - (35%)	Gaps:	241/771 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 REFNPQVAYEFEKYLNPQKLKQH-VLRSEKLRSILEHYAKESGTPLKQMER-QARAIIDEI-GLD 112
            ||.:|          .|...::| |..||:::..|........|...::|. :.|..:|.| .:.
Zfish   102 REVHP----------GPAGDRRHRVHSSERVKKALVTACSSDETKAMELEMPEVRGHLDTILAVT 156

  Fly   113 RN------MAIIRWCGIAITAIGKRICDGFYVNSASMANVRKDMG-KCPVLYLPSHRSYMDFILM 170
            :.      :.::.|  :.:.......|: ..:|...:|.:|:... |.|::|:...:|.:|..|:
Zfish   157 QTFISPSLLRLVNW--LLLKIFDLMFCN-VQINLNQVAALRRSTQLKAPLVYVCVRQSSIDHALI 218

  Fly   171 SYICYYYDIEIPGIAAGMDFHSMF-------GMGTMLRKTGAFFM------RRSFSNDELYWDIF 222
            ....:.:::.:|        :::|       .:.::|::.|...:      .|....|.||..:.
Zfish   219 CLTLFCHNLRVP--------YTIFPAHVRQTWLRSILQRLGVVLLPEGSGSERDAEMDSLYSPVM 275

  Fly   223 REYMYALV---ANYHIGVEFFIEGTRSRNFKALVPKIGLLSMALLPYFTGEVPDVMIVPVSVAYE 284
            ..::..|:   |:..:|:. ..|| .|..:.|.|.:         ....|.||||.||||.::|:
Zfish   276 TSFIGELLRGGASLCVGIS-TAEG-HSGQWLARVHQ---------AISDGLVPDVCIVPVGISYD 329

  Fly   285 ----RVLEEQLFVYELLG--VPKPKESTKGFFK-------ALKIIDERFGKMFLDFGEPIS---- 332
                .|:..|..|...||  :...|...:|..:       :||.:.|. ||..:|.|.|:.
Zfish   330 CLPCHVIRSQASVMSALGFALSLLKGDHRGSVRIHFAQAFSLKEMCES-GKCRVDGGRPLQDLLM 393

  Fly   333 -------VKEFFGHDSAQRMQRAGVGGHLQKLNRQEVELVKQLANEIIYQQQRRIVISTFNLLSL 390
                   :...|.......:....|...|...:||:   ...|...:||.....:.:.:.:|:|.
Zfish   394 TAIVHNRMDSIFSQKDVSWLLPDAVMPELPPAHRQQ---TIALTLHLIYSSTTNMAVMSTSLVSC 455

  Fly   391 YYASQLYAQRSVTLDELAR-----------------------GVLH----LKRIFEQLGAHVST- 427
            ....:  .::.|.:..|.|                       |::|    |.|.:..|.|...|
Zfish   456 LLLHK--HRKGVRVSMLCRDICWLLEEVLFRNTDVGFGGSLVGLVHHAVSLLRPYLLLAAAPPTG 518

  Fly   428 --------TPSSI-----KADVIDAVEIH------------SNILHFATGR-LQFTPMAAKQLAE 466
                    .|.|:     :.|||..|.||            |.::....|. |:|..:..:   .
Zfish   519 EPIIAPRSDPDSLLILSKQCDVITRVFIHEAVGACAVSAMLSEVVGCGGGEDLEFDAVLGQ---N 580

  Fly   467 QIDVKRLK-AHALCPQTMAVAVPMLALQLYINPCM----FWL------ARPAYLLLAALKEQKNQ 520
            ::..|.|: .|.|.|.             ||.||.    |.|      .|...|::
Zfish   581 ELTEKSLQLTHLLSPG-------------YIPPCQNAHSFALDVVDSMVRCGVLVM--------- 623

  Fly   521 QKQSTDISYDASLCALHAHVTTMDALFQHEFII---------ESNREAAEFETHLQLLLDERVVE 576
                .::..||.:|         |.:.:|..:.         .|:.:..|.:.|...|
Zfish   624 ----EEVQTDAPVC---------DFMKRHGVLSWTVSDNPDESSDSDCEEPDIHTYKL------- 668

  Fly   577 VETSGRINVQDNECSHVILAALAPFLC--LYYQL------VVTLRKIPLELEFSNKELLVRVQQH 633
                    .|.::|..::.     |||  |..||      :.:|..:||.:  :.|:.|.::..|
Zfish   669 --------SQPSQCPKLLF-----FLCSLLSVQLRALCWALESLHYLPLPI--TEKDCLSQLHTH 718

  Fly   634 VEQLLQQPGA---SASHVHPYCLALDNLNIAIYALIQRGYLVKSRDSGQMKIASTP 686
            ::...|..||   |:|        :|.:.:|:...|..|.|::.|....:.:.:.|
Zfish   719 LKNRAQLDGARYESSS--------IDLVKMALRTFIDLGVLIEDRQREDVYLDANP 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhap-at	NP_001262957.1	LPLAT_DHAPAT-like	133..338	CDD:153255	51/245 (21%)
gpat2	NP_001082849.1	LPLAT	180..373	CDD:302626	44/212 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820