DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhap-at and Gpat2

DIOPT Version :9

Sequence 1:	NP_001262957.1	Gene:	Dhap-at / 53586	FlyBaseID:	FBgn0040212	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_017447069.1	Gene:	Gpat2 / 296130	RGDID:	1304904	Length:	828	Species:	Rattus norvegicus

Alignment Length:	802	Identity:	153/802 - (19%)
Similarity:	251/802 - (31%)	Gaps:	302/802 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LKQHV-LRSEKLRSILEHY------------AKESGTPLKQMERQARAIIDEIGLDRNMAIIRWC 121
            |:||: ..|:..:.|:|:.            |...|.....::::.:.|:..|.......::|..
  Rat   100 LEQHIPTSSDASQMIMENTGVQNILLGKVPGAAGEGQAPDLVKKEVQRILGHIQTTPRPFLLRLF 164

  Fly   122 GIAITAIGKRICDGFYVNSASMANVRKDMGK-CPVLYLPSHRSYMDFILMSYICYYYDIEIPGIA 185
            ..|:.....|:.....::...|..|.|...: .|:::|.:|:|.:|..|:.::.:...:.:..:|
  Rat   165 SWALLWFLNRLFLNVQLHKGQMKMVHKAAQEGSPLVFLSTHKSLLDGFLLPFVLFSQGLGVLRVA 229

  Fly   186 AGMDFHSMF-GMGTMLRKTGAFFM--RRSFSNDELYWDIFREYMYALVANYHIGVE---FFIE-- 242
              :|..:.. .:..:|||.|..|:  ..:.|.|.....:.|..:.|.|.......:   .|:|
  Rat   230 --LDSRTCSPALRALLRKLGGLFLPPEANLSLDSSEGILARAVVRATVEQLLTSGQPLLIFLEEA 292

  Fly   243 -GTRSRNFKALVPK-IGLLSMALLPYFTGEVPDVMIVPVSVAYERVLEEQLFVYELLGVPKPKES 305
             |.......||... :||:..|:.   .|.|||..:|||:.||:.|.:            .|...
  Rat   293 PGYPGPRLSALGQAWLGLVVQAVQ---AGIVPDATLVPVATAYDLVPD------------APCNM 342

  Fly   306 TKGFFKALKIIDERFGKMFLDFGEPISVKEFFGHDSAQRMQRAGVGGHLQKL------NRQEVEL 364
            |                                ||.|......|.....::|      ||:....
  Rat   343 T--------------------------------HDLAPLGLWTGALAIFRRLCNCWGCNRRVCVR 375

  Fly   365 VKQLANEIIYQQQRRIVISTFNLLSLYYASQLYAQRSVTLDELARGVLHLKRIFEQLGAHVSTTP 429
            | .||.....|:.      |.|..|.:.:.|       ||:.|.:.::        || ..|..|
  Rat   376 V-HLAQPFSLQEY------TINARSCWGSRQ-------TLEHLLQPIV--------LG-ECSVVP 417

  Fly   430 SSIKADVIDAVEIHSNILHFATGRLQFTPMAAKQLA----EQIDVKRLKAHALCPQTMAVAVPML 490
            .:.|..                   ::||..:..||    :|:.|:||..|.|.....:.||...
  Rat   418 DTEKEQ-------------------EWTPPTSLLLALKEEDQLLVRRLSRHVLSASVASSAVMST 463

  Fly   491 ALQLYINPCMFWLARPAYLLLAALKEQK----------------NQQKQSTDISYDASLCALHAH 539
            |:.             |.|||  ||.||                ....:..|:.:...|..|..|
  Rat   464 AIM-------------ATLLL--LKHQKGVVLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLAQH 513

  Fly   540 VTTMDALFQHEFIIESNR-------EAAEFETHLQLL--------LDERV--------------- 574
              |:..|..|..::..::       ......|||..|        |.|.|
  Rat   514 --TLSLLRAHVVLLRVHQGDLVVVPRPGPGLTHLARLSMELLPTFLSEAVGGESVGSAGLGCMWG 576

  Fly   575 ----------------VEVETSGRIN------------VQDNECSHVILAALAPFLCLYYQLVVT 611
                            |....:||:.            :..||              ||.|:::.
  Rat   577 RGKGPLLMLPSLPACAVRGLLAGRVPPEGPWELQGIELLSQNE--------------LYRQILLL 627

  Fly   612 LRKIPLELEFSNKELLVRVQQHVEQLLQQPGASASHVHPYCLALDNLNIAIYALIQRGYLVKSR- 675
            |..:|.:|                 ||.||..|:     ||...:.|:    .|||.|.||...
  Rat   628 LHLLPQDL-----------------LLPQPCQSS-----YCYCQEVLD----RLIQCGLLVAEET 666

  Fly   676 -------DSGQMKIAS--------------------TPGKCLRELETQ------LLEYCQLM--- 704
                   |:|:..:::                    ..|:|.| |..|      .|..|:|:
  Rat   667 PGSRPACDTGRQHLSAKLLWKPSGDFTDSESDDFEEPGGRCFR-LSQQSRCPDFFLFLCRLLSPI 730

  Fly   705 --PFAQYSTAANQQAQFHIAKL 724
              .|||.:|.      .|:.:|
  Rat   731 LKAFAQAATF------LHLGQL 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhap-at	NP_001262957.1	LPLAT_DHAPAT-like	133..338	CDD:153255	41/215 (19%)
Gpat2	XP_017447069.1	LPLAT_DHAPAT-like	176..387	CDD:153255	52/260 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820