DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhap-at and Gpat2

DIOPT Version :9

Sequence 1:	NP_001262957.1	Gene:	Dhap-at / 53586	FlyBaseID:	FBgn0040212	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_006499195.3	Gene:	Gpat2 / 215456	MGIID:	2684962	Length:	829	Species:	Mus musculus

Alignment Length:	779	Identity:	151/779 - (19%)
Similarity:	253/779 - (32%)	Gaps:	282/779 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LKQHVLRS-EKLRSILEHY------------AKESGTPLKQMERQARAIIDEIGLDRNMAIIRWC 121
            |:||:..| :..:.|:|:.            |...|...:.::::.:.|:..|.......::|..
Mouse   127 LEQHIPTSFDASQKIMENTGVQNLLSGRVPGAAGEGQAPELVKKEVQRILGHIQTTPRPFLLRLF 191

  Fly   122 GIAITAIGKRICDGFYVNSASMANVRK---DMGKCPVLYLPSHRSYMDFILMSYICYYYDIEIPG 183
            ..|:.....|:.....::...|..|:|   :.|. |:::|.:|:|.:|..|:.::.:...:.:..
Mouse   192 SWALLWFLNRLFLNVQLHKGQMKMVQKAVQEQGS-PLVFLSTHKSLLDGFLLPFVLFSQGLGVVR 255

  Fly   184 IAAGMDFHSMF-GMGTMLRKTGAFFM----RRSFSNDE--LYWDIFREYMYALVANYHIGVEFFI 241
            :|  :|..:.. .:..:|||.|..|:    ..|..|.|  |...:.|..:..|:.:....:.|..
Mouse   256 VA--LDSRTCSPALRALLRKLGGLFLPPEVNLSLDNSEGILARAVVRATVEELLTSGQPLLIFLE 318

  Fly   242 EGTRSRNFKALVPKIGLLSMALLPYF-----TGEVPDVMIVPVSVAYERVLEEQLFVYELLGVPK 301
            |...|..     |::..|..|.|...     .|.:.|..:|||::||:.|.:
Mouse   319 EPPGSPG-----PRLSALGQAWLGVVIQAVQAGIISDATLVPVAIAYDLVPD------------- 365

  Fly   302 PKESTKGFFKALKIIDERFGKMFLDFGEPISVKEFFGHDSAQRMQRAGVGGHLQKL------NRQ 360
                                       .|.::    .||.|......|.....::|      ||:
Mouse   366 ---------------------------APCNM----NHDLAPLGLWTGALAVFRRLCNCWGCNRR 399

  Fly   361 EVELVKQLANEIIYQQQRRIVISTFNLLSLYYASQLYAQRSVTLDELARGVLHLKRIFEQLGAHV 425
            ....| .||.....|:.      |.|..|.:.:.|       ||:.|.:.::        || ..
Mouse   400 VCVRV-HLAQPFSLQEY------TINARSCWDSRQ-------TLEHLLQPIV--------LG-EC 441

  Fly   426 STTPSSIKADVIDAVEIHSNILHFATGRLQFTPMAAKQLA----EQIDVKRLKAHALCPQTMAVA 486
            |..|.:.|..                   ::||.....||    :|:.|:||..|.|.....:.|
Mouse   442 SVVPDTEKEQ-------------------EWTPPTGLLLALKEEDQLLVRRLSRHVLSASVASSA 487

  Fly   487 VPMLALQLYINPCMFWLARPAYLLLAALKEQK----------------NQQKQSTDISYDASLCA 535
            |...|:.             |.|||  ||.||                ....:..|:.:...|..
Mouse   488 VMSTAIM-------------ATLLL--LKHQKGVVLSQLLGEFSWLTEETLLRGFDVGFSGQLRC 537

  Fly   536 LHAHVTTMDALFQHEFIIESNR-------EAAEFETHLQLL--------LDERV----VEVETSG 581
            |..|  |:..|..|..::..::       ......|||..|        |.|.|    |....:|
Mouse   538 LAQH--TLSLLRAHVVLLRVHQGDLVVVPRPGPGLTHLARLSMELLPTFLSEAVGACAVRGLLAG 600

  Fly   582 RIN------------VQDNECSHVILAALAPFLCLYYQLVVTLRKIPLELEFSNKELLVRVQQHV 634
            |:.            :..||              ||.|:::.|..:|.:|
Mouse   601 RVPPEGPWELQGIELLSQNE--------------LYRQILLLLHLLPQDL--------------- 636

  Fly   635 EQLLQQPGASASHVHPYCLALDNLNIAIYALIQRGYLVKSR--------DSGQMKIAS------- 684
              ||.||..|:     ||...:.|:    .|||.|.||...        |:|:..:::
Mouse   637 --LLPQPCQSS-----YCYCQEVLD----RLIQCGLLVAEETPGSRPACDTGRQHLSAKLLWKPS 690

  Fly   685 -------------TPGKCLRELETQ------LLEYCQLM-----PFAQYSTAANQQAQFHIAKL 724
                         ..|:|.| |..|      .|..|:|:     .|||.:|.      .|:.:|
Mouse   691 GDFTDSESDDFEEPGGRCFR-LSQQSRCPDFFLFLCRLLSPILKAFAQAATF------LHLGQL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhap-at	NP_001262957.1	LPLAT_DHAPAT-like	133..338	CDD:153255	39/219 (18%)
Gpat2	XP_006499195.3	LPLAT_DHAPAT-like	203..415	CDD:153255	50/264 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2937
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810