DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhap-at and acl-6

DIOPT Version :9

Sequence 1:	NP_001262957.1	Gene:	Dhap-at / 53586	FlyBaseID:	FBgn0040212	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001023769.1	Gene:	acl-6 / 178928	WormBaseID:	WBGene00017261	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	773	Identity:	179/773 - (23%)
Similarity:	308/773 - (39%)	Gaps:	179/773 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EQKTPSAAEYM-----RNFKNIIAPGNEAS-MTREFNPQVAYEF-----EKYLNPQKLKQHVLRS 77
            |:..|....|:     .||..|..|..:.| ..|.|.....|.:     ..|.|.:|   .||.|
Worm    25 EEVVPRRERYVDLLEFSNFNGIPYPVVDPSRKPRRFLADFRYSWSIPLIHHYPNVEK---DVLSS 86

  Fly    78 EKLRSILEHYAKESGTPLKQMERQARAI--IDEIGLDRNMAIIRWCGIAITAIGKRICDGFYVNS 140
            :::..::....:::.      |::.||:  ..||....:..|.:.|...:..:.:|:.|...|..
Worm    87 KRVHRVISKLKEQND------EQKNRAVQFFTEISARLSKFICKCCSYVLYKVFRRLMDKLLVCK 145

  Fly   141 ASMANV-RKDMGKCPVLYLPSHRSYMDFILMSYICYYYDIEIPGIAAGMDFHSMFGMGTMLRKTG 204
            ..|..: ..:....|::|||.|||::|::|:::..:::.:::|.||:| |..::.|:|.:||.||
Worm   146 EEMEVLYEAEQTGIPMVYLPLHRSHLDYLLITWCNWHFGLKLPHIASG-DNLNLSGLGWLLRATG 209

  Fly   205 AFFMRRSF------SNDELYWDIFREYMYALVANYHIGVEFFIEGTRSRNFKALVPKIGLLSMAL 263
            |||:||..      ..|:||..|...|:..:::. .:.:|||:||||||..|||.||.||:|..:
Worm   210 AFFIRRRVDPDDERGKDQLYRAILHSYIEQVLSK-DMPIEFFLEGTRSRFGKALTPKNGLISNVV 273

  Fly   264 LPYFTGEVPDVMIVPVSVAYERVLEEQLFVYELLGVPKPKESTKGFFKAL-----KIIDERFGKM 323
            .....|.:.|..:||||..|:.|: |.:|::||:|:||.:||..|.|:.:     |  .::.|.:
Worm   274 EAVQHGFIKDCYLVPVSYTYDAVV-EGIFLHELMGIPKVRESVLGVFRGIFSGFSK--SKQCGVV 335

  Fly   324 FLDFGEPISVKEFFGHDSAQ----------RMQRAGVGGHLQKL---NRQEVE------LVKQLA 369
            .:.:|.||.:.|:....:|.          ||.:.......::|   :|...|      :::.:.
Worm   336 RMHYGRPIRLTEYLATITASLSSNHRTRPVRMTKLSTSFSYRELVPWHRTHSETVDDRTMIRAIG 400

  Fly   370 NEIIYQQQR--------------------RIVISTFNLLSLYYASQLYAQRSVTL---DELARGV 411
            ..::|:.|.                    ::..|||.....:...::.|:....:   .:..:|.
Worm   401 FHVVYEAQMMCSISPVAVVSCLLLAKWRGKVSRSTFERDCEWLCEKIIAEGGDVVGYQSKKTKGS 465

  Fly   412 LHLKRIFEQLGAHVSTTPSSI---------------KADVIDAVEIHSNILHFATGRLQFTPMAA 461
            ..:|..||:|.:.|..|...:               |..||....|.|.|......|...|.::.
Worm   466 ALVKYAFEKLESCVEVTDEYVSPKESHSSFITLAYNKNSVICRFSIKSVIALTIVSRPSGTKLSI 530

  Fly   462 KQLAEQIDVKRLKAHALCPQTMAVAVPMLALQLYINPCMFWLARPAYLLLAALKEQKNQQKQSTD 526
            .|:.|.       |.:||..          ||.     .|...||...|...:.....|::.|..
Worm   531 DQIVED-------ALSLCDW----------LQF-----EFMFCRPCDSLRELVHNVLGQKEWSDP 573

  Fly   527 ISYDASLCALHAHVTTMDALFQHEFIIESNREAAEFETHLQLLLDERVVEVE---TSGRINVQD- 587
            |                     |.|:      .:|.|       |:..::..   .||.:.|:|
Worm   574 I---------------------HGFL------RSEIE-------DDGFLDAGGALNSGTLRVRDA 604

  Fly   588 --NECSHVILAALAPFLCLYYQL--VVTLRKIPLELEFSNKELLVRVQQHVEQLLQQPGASASHV 648
              .|........:.||:...|.:  .|...|.|.|....|.  ::|      ||.||..|....:
Worm   605 KSRETLQFFANLVRPFVQSLYLISSFVVSEKCPTEPTSDNN--IIR------QLCQQSLAGDIDL 661

  Fly   649 HPYCLALDNLNI-----AIYALIQRGYLVKSRD-----SGQMKIASTPGKCLRELETQ 696
             |:...|:::|.     |:..|..:|.|.:|..     ||..::|.......|.||.:
Worm   662 -PFAPLLESINSDSFKNALRVLKDKGLLQRSTPNSTARSGNSRLAELISNLERVLEVK 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhap-at	NP_001262957.1	LPLAT_DHAPAT-like	133..338	CDD:153255	75/216 (35%)
acl-6	NP_001023769.1	PlsB	<58..688	CDD:225488	163/708 (23%)
acl-6	NP_001023769.1	LPLAT_DHAPAT-like	138..350	CDD:153255	75/216 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920