DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhap-at and gpam

DIOPT Version :9

Sequence 1:	NP_001262957.1	Gene:	Dhap-at / 53586	FlyBaseID:	FBgn0040212	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_009305069.1	Gene:	gpam / 100332911	ZFINID:	ZDB-GENE-101026-1	Length:	826	Species:	Danio rerio

Alignment Length:	888	Identity:	181/888 - (20%)
Similarity:	341/888 - (38%)	Gaps:	268/888 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NPVRQSTSSGTVEGESSEQEEQKTPSA--------AEYMRNFK--------NIIAPGNEASMTRE 52
            ||   .|.|..::....:|:...:||.        .|.:.|.|        :...|   .|..|.
Zfish    18 NP---DTGSACLKHPCEDQDRSSSPSVLRCVTTTWKEGLLNRKRPFVGRCCHSCTP---QSQDRL 76

  Fly    53 FNPQV--------------------------AY-------EFEKYLNPQKLKQHVLRSEKLRSIL 84
            |||.:                          :|       :.:|.:..:.:.::||.:.:|...:
Zfish    77 FNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFVLERDVQKDMFARNVVENVLNNSRLECAI 141

  Fly    85 EHYA----KESGTP------LKQMERQARAIIDEIGLDRNMAIIRWCGIAITAIGKRICDGFY-- 137
            ...|    :|...|      :.::.|:||..:.|:..:.:.|:||..|..:.    ::.:||:
Zfish   142 VEVANEGVQEDAEPGVDPKAVSKVRRKARGWLQEMVANISPALIRLTGWVLL----KLFNGFFWS 202

  Fly   138 --VNSASMANVRKDMGK--CPVLYLPSHRSYMDFILMSYICYYYDIEIPGIAAGMDFHSMFGMGT 198
              ::...:..|:|...:  .|:::||.|:|::|::|:::|.:.::|:.|.||||.:.:... :.|
Zfish   203 IQIHKGQLEMVKKAASEYNAPLVFLPVHKSHIDYLLITFILFCHNIKAPHIAAGNNLNIPI-LST 266

  Fly   199 MLRKTGAFFMRRSF------SNDELYWDIFREYMYALVANYHIGVEFFIEGTRSRNFKALVPKIG 257
            ::||.|.||:||..      ..|.||..:...|...|:..... :|.::||||||:.|....:.|
Zfish   267 LIRKLGGFFIRRKMDETSDGKKDVLYRSLLHAYTEELLRQQQF-LEVYLEGTRSRSGKPSPARAG 330

  Fly   258 LLSMALLPYFTGEVPDVMIVPVSVAYERVLEEQLFVYELLGVPKPKES----TKGFFKALKIIDE 318
            :||:.:.......:|||:||||.::|:|::|.. :..|.||.||..||    ..|.|:.|:   :
Zfish   331 MLSIVVDTLCASTIPDVLIVPVGISYDRIIEGN-YNSEQLGKPKKNESLWGIACGVFRMLR---K 391

  Fly   319 RFGKMFLDFGEPISVKEFFGHDSAQRMQ-------------------RAGVGG----HLQKLNRQ 360
            .:|.:.:||.:|.|:||:.....::.:|                   :|...|    ||......
Zfish   392 NYGCVRVDFTQPFSLKEYLDTQRSRHLQASLTLEQILLPIIIATQPDQAVFNGENENHLNSDLSD 456

  Fly   361 EV---ELVKQLANEIIYQQQRRIVISTFNLLSLYYASQLYAQR-SVTLDELARGVLHLK-----R 416
            |.   :::..||..:::...:...|.:.::::...   ||..| .|.|.:|.....::|     |
Zfish   457 EPWRRQVIADLAKHVLFSASKSSAIMSTHIVACLL---LYRHRQGVLLSKLVEDFFNMKEEILSR 518

  Fly   417 IFE----------------QLGAHVSTTPSSIKADVIDA----------VEIHSN-ILH------ 448
            .|:                .||..|:.|.::...:.|.:          :..:|| :.|
Zfish   519 DFDLGFSGNSEDVVMHALSLLGNCVNVTSTNKNTEFIISPSNTVPALFELNFYSNGLFHVFIADA 583

  Fly   449 -FATGRL----QFTPMAAKQ-------LAEQIDVKRLK--AHALCPQTMAVAVPMLALQLYINPC 499
             .|...|    :.||.:|.:       |:::..::|..  :|.|..: :|||:|...|....:..
Zfish   584 IIACSALALLREQTPASASEQNPSSTLLSQERLIRRAAGLSHFLSNE-VAVALPCQTLYQVFHDA 647

  Fly   500 MFWLARPAYLLLA--------------------ALKEQKNQQKQSTDISYDASLCALHAHVTTMD 544
            :..|.....|::|                    ||..:.:::.:.:|..               |
Zfish   648 ITRLIEYGVLIVAEEDQEELSPSEEPWPKKFPEALSWRSDEEDEDSDFG---------------D 697

  Fly   545 ALFQHEFIIESNREAAEFETHLQLLLDERVVEVETSGRINVQDNECSHVILAALAPFLCLYYQLV 609
            ........:..:.|..||.|.||.:|.. |:|..:...|.:      |.:.:.::
Zfish   698 EQRDRYLKVSPSAEHQEFYTFLQRILTP-VLEAYSGAAIFI------HSLTSPIS---------- 745

  Fly   610 VTLRKIPLELEFSN---KELLVRVQQHVEQLLQQPGASASHVHPYCLALDNLNIAIYALIQRGYL 671
                    |.::::   |.||.|.::.|...    |.||:|                      ||
Zfish   746 --------ERDYTHQLFKYLLTRTERGVSMY----GESATH----------------------YL 776

  Fly   672 VKS-----RDSGQMKIASTPGKCLRELETQLLEYCQLMPFAQY 709
            ||:     ::.|.:|.....|.|..||.:..:.........||
Zfish   777 VKNTVKTFKELGVLKERREDGVCRLELSSTFIPQANKNKLLQY 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhap-at	NP_001262957.1	LPLAT_DHAPAT-like	133..338	CDD:153255	69/220 (31%)
gpam	XP_009305069.1	PlsB	<125..>599	CDD:225488	112/486 (23%)
gpam	XP_009305069.1	LPLAT_DHAPAT-like	200..411	CDD:153255	67/216 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129142at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920