DRSC/TRiP Functional Genomics Resources

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Protein Alignment Debcl and Mcl1

DIOPT Version :10

Sequence 1:NP_788278.1 Gene:Debcl / 53585 FlyBaseID:FBgn0029131 Length:300 Species:Drosophila melanogaster
Sequence 2:NP_068618.2 Gene:Mcl1 / 60430 RGDID:620525 Length:330 Species:Rattus norvegicus


Alignment Length:331 Identity:64/331 - (19%)
Similarity:115/331 - (34%) Gaps:114/331 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PPPKLAKFKSSSLDHEIYTANRRGTIATASSDWKALRGGVGGGAGGPGSVPNPSNGRSLHAGGPM 71
            |||..|:      |.::          |||::.:.|:        .||.:..|....:..|...|
  Rat    60 PPPVGAE------DPDV----------TASAERRLLK--------SPGLLAVPPEEMAASAAAIM 100

  Fly    72 T----------------------------RAASTSSLASSTRTMTNYQEYKMDIINQGKCLCGQY 108
            :                            .|.|:.:..|...|....:|...::..|...:..:|
  Rat   101 SPEEELDGCEPEVLSKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEDDELYRQSLEIISRY 165

  Fly   109 IRAR---------LRRAGVLNRKVTQRLRNILDPGSSHVVYEVFPALNSMGEELERMHPRVYTNI 164
            :|.:         |..||...|:..:.||.:                   |:.::|.|...:..:
  Rat   166 LREQATGSKDAKPLGEAGAAGRRALETLRRV-------------------GDGVQRNHETAFQGM 211

  Fly   165 SRQLSRAPFGELEDSDMAPMLLNLVAKDLFRSSIT-WGKIISIFAVCGGFA---IDCVRQGHFDY 225
            .|:|      ::::.|.... .:.|...:|:..:| ||:|:::.:. |.|.   :..:.|     
  Rat   212 LRKL------DIKNEDDVKS-FSRVMTHVFKDGVTNWGRIVTLISF-GAFVAKHLKSINQ----- 263

  Fly   226 LQCLIDGLAEIIEDDLVY----WLIDNGGWLGLSR--HIRPRVGE-----FTFLGWLTLFVTISA 279
             :..|:.|||.|.|.||.    ||:...||.|...  |::...|.     ..|.|    ...:.|
  Rat   264 -ESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAG----VAGVGA 323

  Fly   280 G-AYMV 284
            | ||::
  Rat   324 GLAYLI 329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DebclNP_788278.1 Bcl-2_like 107..257 CDD:132900 36/168 (21%)
Mcl1NP_068618.2 PEST-like. /evidence=ECO:0000250 85..155 8/69 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 129..153 5/23 (22%)
Bcl-2_like 155..298 CDD:132900 37/175 (21%)
BH3 189..203 3/32 (9%)
BH1 232..252 5/20 (25%)
BH2 284..299 5/14 (36%)

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