DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Debcl and BCL2L1

DIOPT Version :9

Sequence 1:	NP_788278.1	Gene:	Debcl / 53585	FlyBaseID:	FBgn0029131	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_001304848.1	Gene:	BCL2L1 / 598	HGNCID:	992	Length:	233	Species:	Homo sapiens

Alignment Length:	166	Identity:	42/166 - (25%)
Similarity:	72/166 - (43%)	Gaps:	28/166 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 EVFP------ALNSMGEELERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLVAKDLFRSSIT 199
            ||.|      ||...|:|.|..:.|.:::::.||...|       ..|......|..:|||..:.
Human    79 EVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITP-------GTAYQSFEQVVNELFRDGVN 136

  Fly   200 WGKIISIFAVCGGFAIDCVRQGHFDYLQCLID----GLAEIIEDDLVYWLIDNGGW------LGL 254
            ||:|::.|:..|...::.|.:    .:|.|:.    .:|..:.|.|..|:.:||||      .|.
Human   137 WGRIVAFFSFGGALCVESVDK----EMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGN 197

  Fly   255 SRHIRPRVGEFTFLGWLTLFVTISAGAYMVSNVCRR 290
            :.....|.|:..|..|....:|: ||..::.::..|
Human   198 NAAAESRKGQERFNRWFLTGMTV-AGVVLLGSLFSR 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Debcl	NP_788278.1	Bcl-2_like	107..257	CDD:132900	34/131 (26%)
BCL2L1	NP_001304848.1	bcl-2	1..233	CDD:273308	42/166 (25%)
		BH4	4..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..71
		BH3	86..100		5/13 (38%)
		BH1	129..148		7/18 (39%)
		BH2	180..195		5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4728
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810