Protein Alignment Debcl and Mcl1

DIOPT Version :10

• Sequence 1: NP_788278.1
• Gene: Debcl / 53585
• FlyBaseID: FBgn0029131
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_032588.1
• Gene: Mcl1 / 17210
• MGIID: 101769
• Length: 331
• Species: Mus musculus
• Alignment Length: 236
• Identity: 53/236 - (22%)
• Similarity: 91/236 - (38%)
• Gaps: 62/236 - (26%)

  Fly    74 AASTSSLASSTRTMTNYQEYKMDIINQGKCLCGQYIRAR---------LRRAGVLNRKVTQRLRN 129
            |.|:.:..|...|....:|.:.|:..|...:..:|:|.:         |..||...|:..:.||.
Mouse   132 AKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRR 196

  Fly   130 ILDPGSSHVVYEVFPALNSMGEELERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLVAKDLF 194
            :                   |:.::|.|...:..:.|:|.....|:::.       .:.|...:|
Mouse   197 V-------------------GDGVQRNHETAFQGMLRKLDIKNEGDVKS-------FSRVMVHVF 235

  Fly   195 RSSIT-WGKIISIFAVCGGFA---IDCVRQGHFDYLQCLIDGLAEIIEDDLVY----WLIDNGGW 251
            :..:| ||:|:::.:. |.|.   :..|.|..|      |:.|||.|.|.||.    ||:...||
Mouse   236 KDGVTNWGRIVTLISF-GAFVAKHLKSVNQESF------IEPLAETITDVLVRTKRDWLVKQRGW 293

  Fly   252 LGLSR--HIRPRVGE-----FTFLGWLTLFVTISAG-AYMV 284
            .|...  |::...|.     ..|.|    ...:.|| ||::
Mouse   294 DGFVEFFHVQDLEGGIRNVLLAFAG----VAGVGAGLAYLI 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Debcl	NP_788278.1	Bcl-2_like	107..257	CDD:132900	38/168 (23%)
Mcl1	NP_032588.1	PEST-like. /evidence=ECO:0000250	85..156		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..154		5/21 (24%)
		Bcl-2_like	156..299	CDD:132900	39/175 (22%)
		BH3	190..204		3/32 (9%)
		BH1	234..253		5/19 (26%)
		BH2	285..300		5/14 (36%)