DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Debcl and Bcl2l2

DIOPT Version :9

Sequence 1:	NP_788278.1	Gene:	Debcl / 53585	FlyBaseID:	FBgn0029131	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_031563.1	Gene:	Bcl2l2 / 12050	MGIID:	108052	Length:	193	Species:	Mus musculus

Alignment Length:	198	Identity:	38/198 - (19%)
Similarity:	73/198 - (36%)	Gaps:	30/198 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 KCLCGQYIRARLRRAGVLNRKVTQRLRNILDPGSSHVVYEVFPALNSMGEELERMHPRVYTNISR 166
            :.|...::..:||:.|.:..         ..||.......:..|:.:.|:|.|....|.:::::.
Mouse    11 RALVADFVGYKLRQKGYVCG---------AGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAA 66

  Fly   167 QLSRAPFGELEDSDMAPMLLNLVAKDLFRSSITWGKIISIFAVCGGFAIDCVRQGHFDYLQCLID 231
            ||...|       ..|......|:.:||:....||::::.|........:.|.:.....:..:.|
Mouse    67 QLHVTP-------GSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQD 124

  Fly   232 GLAEIIEDDLVYWLIDNGGWL---------GLSRHIRPRVGEF-----TFLGWLTLFVTISAGAY 282
            .:...:|..|..|:..:|||.         .|....|.|.|.:     ...|.:.|...::.||:
Mouse   125 WMVAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAF 189

  Fly   283 MVS 285
            ..|
Mouse   190 FAS 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Debcl	NP_788278.1	Bcl-2_like	107..257	CDD:132900	29/158 (18%)
Bcl2l2	NP_031563.1	BH4	9..29		4/17 (24%)
		bcl-2	11..193	CDD:273308	38/198 (19%)
		BH1	85..104		5/18 (28%)
		BH2	136..151		4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4728
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810