Protein Alignment Debcl and BCL2L10

DIOPT Version :10

• Sequence 1: NP_788278.1
• Gene: Debcl / 53585
• FlyBaseID: FBgn0029131
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_001293097.1
• Gene: BCL2L10 / 10017
• HGNCID: 993
• Length: 241
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 52/245 - (21%)
• Similarity: 79/245 - (32%)
• Gaps: 99/245 - (40%)

  Fly   109 IRARLRRAGVLNRKVTQRLRNIL-----DPGSSHVVYEVFPA------LNSMGEELERMHPRVYT 162
            :|.|...|..|..:....|.:.|     :||:.    |..|:      |.|....|.::|...:
Human     5 LRERTTMADPLRERTELLLADYLGYCAREPGTP----EPAPSTPEAAVLRSAAARLRQIHRSFF- 64

  Fly   163 NISRQLSRAPFGELEDSDMAPMLLNLVAKDLFRSS--ITWGKIISIFAVCG-------------- 211
              |..|. .|....|       |:.|:|..:...|  .|||:::::....|
Human    65 --SAYLG-YPGNRFE-------LVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWK 119

  Fly   212 --GF-----------AIDCVRQGHFDYLQCLIDGLAEIIEDDLV----YWLIDNGGWL------- 252
              ||           |.||.|             |..::...|:    .||...|||:
Human   120 KWGFQPRLKEQEGDVARDCQR-------------LVALLSSRLMGQHRAWLQAQGGWVSTRRTPG 171

  Fly   253 ---GLSRHIRPRVGEFTFLGWL---------TLFVTISAG----AYMVSN 286
               |.:...|||    .:.|||         |.|:..:||    ..:|:|
Human   172 HGAGRAAGKRPR----GWHGWLLSLLQDPLSTGFLEKTAGPGFSVMLVNN 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Debcl	NP_788278.1	Bcl-2_like	107..257	CDD:132900	40/201 (20%)
BCL2L10	NP_001293097.1	Bcl-2_like	16..164	CDD:132900	34/175 (19%)
		BH1	86..105		4/18 (22%)
		Required for Ca(2+) binding. /evidence=ECO:0000269|PubMed:21705382	118..133		2/14 (14%)