DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Debcl and bcl2b

DIOPT Version :9

Sequence 1:	NP_788278.1	Gene:	Debcl / 53585	FlyBaseID:	FBgn0029131	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	XP_001341214.1	Gene:	bcl2b / 100007048	ZFINID:	ZDB-GENE-110411-185	Length:	209	Species:	Danio rerio

Alignment Length:	208	Identity:	51/208 - (24%)
Similarity:	86/208 - (41%)	Gaps:	29/208 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 INQGKCLCGQYIRARLRRAG----------VLNRKVTQRLRN-ILDPGSSHVVYE-VFPALNSMG 150
            :...:.:...||..:|.:.|          |.|.....|..| ::.|.|.|..|. :...|...|
Zfish     6 VYNNRSIVENYIHHKLWKKGYVWEVNGHDSVSNGLSMGRQENSVVSPSSRHDPYSALHNVLREAG 70

  Fly   151 EELERMHPRVYTNISRQLSRAPFGELEDSDMAPMLLNLVAKDLFRSSITWGKIISIFAVCGGFAI 215
            :|||.::...:..:|:||.       ..|..|....|.|..:|||..:.||:||:.|...|....
Zfish    71 DELESLYQSDFAEMSKQLH-------VTSITAHQRFNAVIDELFRDGVNWGRIIAFFEFGGTVCA 128

  Fly   216 DCVRQGHFDYLQCLIDGLAEIIEDDLVYWLIDNGGW---LGLSRHIRPRVGEFTFLGWLTLF--- 274
            :||.:.....:..:...:|:.:...|..|:.:||||   :.|....|..|...::...:|:|
Zfish   129 ECVNKEMTGQVDNIAVWMADYLNGPLHGWIRENGGWEAFVELYSSQRDSVFHSSWSSIVTVFGLA 193

  Fly   275 ----VTISAGAYM 283
                |.::.|||:
Zfish   194 ALGAVGLTIGAYL 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Debcl	NP_788278.1	Bcl-2_like	107..257	CDD:132900	43/164 (26%)
bcl2b	XP_001341214.1	BH4	7..29	CDD:280361	4/21 (19%)
		bcl-2	9..206	CDD:273308	50/203 (25%)
		Bcl-2_like	43..170	CDD:132900	36/133 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4728
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810